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Health Videos & Features Breast Cancer Trials: How Have They Changed Breast Cancer Therapy?
Today there are a wide variety of treatments for breast cancer. But recently, several clinical trials have focused light on a category of treatment known as hormonal therapy. Three types of drugs constitute hormonal therapy. The selective estrogen receptor modulators, or SERMs which include tamoxifen (Nolvadex), Evista (raloxifene) and Fareston (tormifene). The aromatase inhibitors which include Arimidex (anastrozole), Femara (letrozole) and Aromasin (exemestane). And the estrogen receptor downregulators which currently only have one family member, fulvestrant (Faslodex). Although they're mechanism of action differs, the goal of all of these agents is to inhibit the effect of estrogen on breast cancer cells. Tamoxifen has long been considered the "gold standard" of breast cancer treatment. But in 2002 the ATAC trial found that Arimidex (anastrozole) appeared to delay the recurrence of breast cancer more than tamoxifen. Follow up studies released in 2005 confirmed thi
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