 |
|
|
|
Can We Prevent Type 1 Diabetes By Modifying Infant Nutrition?Within the next 10 years the EU-funded Diabetes Prevention study, part of an international study called TRIGR (Trial to Reduce IDDM in the Genetically at Risk), coordinated at the University of Helsinki, Finland, will generate a definite answer to the question whether early nutritional modification may prevent type 1 diabetes later in childhood. Type 1 diabetes is a growing health problem among European children. European data indicate that the disease incidence has increased five-six-fold among children under the age of 15 years after World War II, and there are no signs that the increase in incidence is levelling off. The most conspicuous increase has been seen among children under the age of 5 years. The TRIGR study is the first study ever aimed at primary prevention of type 1 diabetes. The study is designed to answer to the question whether excluding cow's milk protein from the infant's diet decreases the risk of fu-ture diabetes. All subjects are followed for 10 years to get information on whether the dietary recommendations for infants at increased genetic risk of type 1 diabetes should be revised. Starting in May 2002, 76 study centres from 15 countries (Australia, Canada, the Czech Republic, Estonia, Finland, Germany, Hungary, Italy, Luxembourg, the Netherlands, Poland, Spain, Sweden, Switzerland and USA) have been recruiting families for the study. To be eligible the newborn infant has to have at least one family member (mother, father and/or sib) affected by type 1 diabetes and carry a HLA genotype conferring increased risk for type 1 diabetes. The initial recruitment target of 2032 eligible infants was reached at the be-ginning of September 2006, but the Study Group has decided to continue recruitment till the end of December 2006 (when the EU contribution will finish) to make the study even more powerful statistically. A majority of the study participants (52%) have been recruited in Europe. The International Coordinating Cen-tre (ICC) is located at the University of Helsinki, Helsinki, Finland and the Data Management Unit (DMU) at the University of South Florida, Tampa, Florida, USA. The trial has logistically been a true challenge for both the ICC and DMU. DMU has been successful in establishing a secure, real-time, web-based, interactive data management system that works extremely well. This system can be directly applied to future international mul-ticentre studies. The TRIGR study is generating a wealth of information on breast-feeding practices, infant nutrition and growth in young children in various countries. At 2 weeks of age almost all the participating infants were breast-fed. Exclusive breast-feeding continued longer in Europe than in North America. More than one third of the infants (35 %) received other foods in addition to breast milk and/or infant formulas at the age of 4 months, while WHO recommends that supplementary food should be introduced at the earliest by the age of 6 months. In Europe the first foods to be introduced are typically vegetables and fruits, whereas gluten-free cereals are most commonly introduced in North America. Newborn infants in Northern Europe (NE) had a higher birth weight but a shorter birth length than infants in Central and Southern Europe (CSE). The NE children remained heavier than those from CSE at least up to the age of 18 months. The NE children were also taller than the CSE children starting already from the age of 3 months up to the age of 18 months. Accelerated growth in infancy has been identified as a risk factor for type 1 diabetes later in childhood. Accordingly the observed growth pattern may contribute to the higher incidence of type 1 diabetes in NE compared to CSE.
Can't find it? Try searching ScienceDaily or the entire web with: |
Health Videos & Features
Treating the Nerve Damage from Diabetes
 Approximately half of all people in the U.S with diabetes will experience some form of nerve damage. About a third of this group will develop a complication of diabetes known as peripheral neuropathy. In patients with diabetic peripheral neuropathy, or DPN, the high blood glucose associated with diabetes damages the nerves that go to the periphery of the body, including the toes, feet, legs, arms, hands and fingers. Patients can experience pain, burning, stinging and a "pins and needles" sensation. Conversely, some patients with DPN experience loss of sensation in their limbs and cannot feel any pain. The treatment of DPN has two goals. The first is to stop the progression of the disease and the development of complications. The second goal is to alleviate the painful symptoms of DPN. The most effective way to delay the progression of DPN is to control the patient's diabetes through careful monitoring of their blood glucose levels and their hemoglobin A1C levels. In t
Related News SectionsRelated News Topics> more ...
Related Science Stories> more ...
Related Encyclopedia Articles> more ...
Related Book ReviewsDiabetes Can Be Prevented With Drug Therapy, Study Shows (September 15, 2006) -- A drug used to treat diabetes may significantly reduce the chances of developing the disease when taken by those most at risk, according to an international trial led by CIHR-funded researchers at ... > full story Researchers Determine That MS And Diabetes Are Closely Linked Diseases (March 22, 2001) -- A team of researchers led by Hospital for Sick Children (HSC) senior scientist Michael Dosch has determined that multiple sclerosis and type I (juvenile) diabetes mellitus are far more closely linked ... > full story Insulin Injections Fail To Prevent Type 1 Diabetes; Separate Prevention Trial Tests Benefit Of Oral Insulin (July 2, 2001) -- Low-dose insulin injections do not delay or prevent type 1 diabetes in people who have a high risk (50 percent or greater) of developing the disease within 5 years, researchers announced at the ... > full story Adult Lifestyle Biggest Risk Factor For Diabetes, Study Finds (July 6, 2005) -- ADULT lifestyle - not childhood experience as previously thought - has the biggests influence on your chances of developing Type 2 diabetes in later life according to new research by the University ... > full story Drug Shows Promise In Preventing Type 1 Diabetes (April 30, 2003) -- An anti-inflammatory drug called lisofylline, originally developed as an infection-fighter for cancer patients, could be beneficial for people at risk for Type 1 diabetes, according to researchers at ... > full story New Study Shows Targeted Lifestyle Changes Could Turn The Tide Aganst Diabetes And Heart Disease; Results Show A 20% Improvement In The Body's Ability To Use Insulin (October 3, 2001) -- World-first research at the University of Otago in New Zealand could help reverse the world-wide epidemic of diabetes and significantly reduce heart disease. The study of 79 people aged 35-60 ... > full story
Waist Size Linked To Diabetes Risk In Adult Men (March 28, 2005) -- The circumference of a man's waist is a better predictor of his risk of developing type 2 diabetes than his body mass index (BMI), which is a weight-to-height ratio, or waist-to-hip ratio alone. ... > full story
Diabetes, Not Obesity, Increases Risk Of Developing Critical Illness And Early Death (September 25, 2006) -- Diabetes puts people at risk of developing critical illness and dying early, but obesity without diabetes does not. A study published today in the open access journal Critical Care reveals that ... > full story Diabetes mellitus type 1 -- Type 1 diabetes (formerly known as "childhood" or "juvenile" diabetes or "insulin dependent" diabetes) is most commonly diagnosed in children and adolescents.The most important forms of diabetes are ... > full article Diabetic diet -- The diet frequently recommended for people who suffer from diabetes mellitus is one that is high in dietary fibre, especially soluble fibre, but low in fat (especially saturated fat) and sugar. ... > full article Diabetes mellitus type 2 -- Diabetes mellitus type 2 (formerly called diabetes mellitus type II, non-insulin-dependent diabetes, NIDDM or adult-onset diabetes) is a long-term metabolic disorder that is primarily characterized ... > full article Health benefits of tea -- The possible beneficial health effects of tea consumption have been suggested and supported by some studies, but others have not found beneficial ... > full article Birth weight -- Birth weight is the weight of a baby at its birth. It has direct links with the gestational age at which the child was born and can be estimated during the pregnancy by measuring fundal ... > full article Glycemic index -- Glycemic index (also glycaemic index, GI) is a ranking system for carbohydrates based on their immediate effect on blood glucose levels. It compares carbohydrates gram for gram in individual foods, ... > full article Blood sugar -- In medicine, blood sugar is a term used to refer to levels of glucose in the blood. Blood sugar concentration, or serum glucose level, is tightly regulated in the human body. Glucose, transported via ... > full article Whole grain -- Whole grains are cereal grains which retain the bran and germ as well as the endosperm, in contrast to refined grains which retain only the endosperm. Whole meal products are made from whole grain ... > full article Hyperglycemia -- Hyperglycemia or High Blood Sugar is a condition in which an excessive amount of glucose circulates in the blood plasma. Hyperglycemia is one of the classic symptoms of diabetes mellitus, others ... > full article Premature birth -- Premature birth (also known as preterm birth) is defined medically as childbirth occurring earlier than 37 completed weeks of gestation. Most pregnancies last about 40 weeks. Premature babies are ... > full article
|
||||||||||||||||||||||
