The PANTHER (Protein ANalysis THrough Evolutionary Relationships) Classification System is a unique resource that classifies genes by their functions, using published scientific experimental evidence and evolutionary relationships to predict function even in the absence of direct experimental evidence. Proteins are classified by expert biologists into families and subfamilies of shared function, which are then categorized by molecular function and biological process ontology terms. For an increasing number of proteins, detailed biochemical interactions in canonical pathways are captured and can be viewed interactively.

To get started, try either a text search, browsing by function, or take a look at interactive pie charts that summarize the functions of whole genomes for Human, Mouse, Rat and Drosophila melanogaster.

PANTHER is maintained by the Evolutionary Systems Biology Group at SRI.