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InterPro: IPR000370 Prostacyclin (prostanoid IP) receptor
Protein matches
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UniProtKB Matches: 15 proteins |
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Accession
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IPR000370 Prostglndn_IP_rcpt |
Type
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Family |
Signatures
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InterPro Relationships
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Parent
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IPR001105 Thromboxane receptor
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GO Term annotation
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Process
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GO:0007186 G-protein coupled receptor protein signaling pathway
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Component
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GO:0016021 integral to membrane
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InterPro annotation
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Abstract
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G-protein-coupled receptors, GPCRs, constitute a vast protein family that encompasses a wide range of functions (including various autocrine, paracrine and endocrine processes). They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs, as they embrace a group of families for which there are indications of evolutionary relationship, but between which there is no statistically significant similarity in sequence [1]. The currently known clan members include the rhodopsin-like GPCRs, the secretin-like GPCRs, the cAMP receptors, the fungal mating pheromone receptors, and the metabotropic glutamate receptor family. There is a specialised database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone, neurotransmitter and light receptors, all of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character, the amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7
transmembrane (TM) helices [2, 3, 4]. Prostanoids (prostaglandins (PG) and thromboxanes (TX)) mediate a wide variety of actions and play important physiological roles in the cardiovascular and immune systems, and in pain sensation in peripheral systems [5]. PGI2 and TXA2 have opposing actions, involving regulation of the interaction of platelets with the vascular endothelium, while PGE2, PGI2 and PGD2 are powerful vasodilators and potentiate the action of various autocoids to induce plasma extravasation and pain sensation. To date, evidence for at least 5 classes of prostanoid receptor has been obtained. However, identification of subtypes and their distribution is hampered by expression of more than one receptor within a tissue, coupled with poor selectivity of available agonists and antagonists. IP receptors induce relaxation in a range of smooth muscles, including
blood vessels, and potently inhibit platelet activation. The receptors
activate adenylyl cyclase through G-proteins [5].
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Database links
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Example proteins
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P43119 Prostacyclin receptor (Prostanoid IP receptor) (PGI receptor) (Prostaglandin I2 receptor)
P43252 Prostacyclin receptor (Prostanoid IP receptor) (PGI receptor) (Prostaglandin I2 receptor)
P43253 Prostacyclin receptor (Prostanoid IP receptor) (PGI receptor) (Prostaglandin I2 receptor)
More proteins
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Publications
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1.
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Attwood T.K.
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Findlay J.B.
Fingerprinting G-protein-coupled receptors.
Protein Eng. 7 195-203 1994
[PubMed: 8170923]
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2.
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Birnbaumer L.
G proteins in signal transduction.
Annu. Rev. Pharmacol. Toxicol. 30 675-705 1990
[PubMed: 2111655]
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3.
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Casey P.J.
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Gilman A.G.
G protein involvement in receptor-effector coupling.
J. Biol. Chem. 263 2577-2580 1988
[PubMed: 2830256]
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4.
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Attwood T.K.
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Findlay J.B.
Design of a discriminating fingerprint for G-protein-coupled receptors.
Protein Eng. 6 167-76 1993
[PubMed: 8386361]
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5.
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Watson S.
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Arkinstall S.
Prostanoids.
The G-protein Linked Receptor Factsbook. 1994
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InterPro {cache:version}
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