|
InterPro: IPR002002 Octopamine receptor
Protein matches
|
UniProtKB Matches: 23 proteins |
|
Accession
|
IPR002002 Octopmn_rcpt |
Type
|
Family |
Signatures
|
|
InterPro Relationships
|
Parent
|
IPR000276 Rhodopsin-like GPCR superfamily
|
GO Term annotation
|
Process
|
GO:0007186 G-protein coupled receptor protein signaling pathway
|
Function
|
GO:0004989 octopamine receptor activity
|
Component
|
GO:0016021 integral to membrane
|
InterPro annotation
|
Abstract
|
G-protein-coupled receptors, GPCRs, constitute a vast protein family that encompasses a wide range of functions (including various autocrine, paracrine and endocrine processes). They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs, as they embrace a group of families for which there are indications of evolutionary relationship, but between which there is no statistically significant similarity in sequence [1]. The currently known clan members include the rhodopsin-like GPCRs, the secretin-like GPCRs, the cAMP receptors, the fungal mating pheromone receptors, and the metabotropic glutamate receptor family. There is a specialised database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone, neurotransmitter and light receptors, all of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character, the amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7
transmembrane (TM) helices [2, 3, 4]. The insect octopamine receptor mediates the attenuation of adenylate cyclase
activity. Sequence and pharmacological comparisons indicate that the
octopamine receptor is unique, but closely related to mammalian adrenergic
receptors, perhaps as an evolutionary precursor [5, 6].
|
Database links
|
|
Publications
|
1.
|
Attwood T.K.
,
Findlay J.B.
Fingerprinting G-protein-coupled receptors.
Protein Eng. 7 195-203 1994
[PubMed: 8170923]
|
2.
|
Birnbaumer L.
G proteins in signal transduction.
Annu. Rev. Pharmacol. Toxicol. 30 675-705 1990
[PubMed: 2111655]
|
3.
|
Casey P.J.
,
Gilman A.G.
G protein involvement in receptor-effector coupling.
J. Biol. Chem. 263 2577-2580 1988
[PubMed: 2830256]
|
4.
|
Attwood T.K.
,
Findlay J.B.
Design of a discriminating fingerprint for G-protein-coupled receptors.
Protein Eng. 6 167-76 1993
[PubMed: 8386361]
|
5.
|
Arakawa S.
,
Gocayne J.D.
,
McCombie W.R.
,
Urquhart D.A.
,
Hall L.M.
,
Fraser C.M.
,
Venter J.C.
Cloning, localization, and permanent expression of a Drosophila octopamine receptor.
Neuron 4 343-354 1990
[PubMed: 2156539]
|
6.
|
Saudou F.
,
Amlaiky N.
,
Plassat J.L.
,
Borrelli E.
,
Hen R.
Cloning and characterization of a Drosophila tyramine receptor.
EMBO J. 9 3611-3617 1990
[PubMed: 2170118]
|
|
InterPro {cache:version}
|