Model of filopodia collapse
Summary
| Title | Model of filopodia collapse |
| Description | In neuronal growth cones, filopodia protrusion stops when a repulsive signal binds to its receptor on the cell surface. Receptor-binding transiently inactivates Rac1 GTPase and prevents it from promoting actin assembly. Resumption of Rac1 activity coincides with filopodia collapse and is required for endocytosis of the collapsing plasma membrane and reorganization of F-actin [32]. RhoA and its effector, ROCK, are activated downstream of repulsive cues [31, 32, 33] and their activity has been implicated in reducing actin polymerization following treatment with repulsive signals [34]. |
| Date | 2013 |
| Author | Mecanobiology Institute, Singapore |
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Model of filopodia collapse. In MBInfo Wiki, Retrieved 10/21/2014 from http://www.mechanobio.info/figure/figure/1385356606058.jpg.html