- U Host (Wii U eShop)
- U.N. Squadron (SNES)
- Ubongo (WiiWare)
- Ubongo (DSiWare)
- Ucchannanchan no Honō no Challenger: Denryū Iraira Bō (N64)
- UCraft (Wii U eShop)
- uDraw Studio (Wii)
- UFC Personal Trainer: The Ultimate Fitness System (Wii)
- Ufouria: The Saga (NES)
- Ultimate Chicken Horse (Switch eShop)
- Ultimate Duck Hunting (Wii)
- Ultimate Fishing Simulator (Switch)
- Ultimate NES Remix (3DS)
- Ultimate Runner (Switch eShop)
- Ultimate Shooting Collection (Wii)
- Ultimate Spider-Man (DS)
- Ultra Hyperball (Switch eShop)
- Ultra Space Battle Brawl (Switch eShop)
- Ultra Street Fighter II: The Final Challengers (Switch)
- Ultratron (Wii U eShop)
- Umihara Kawase Fresh! (Switch)
- Unalive (Wii U eShop)
- Unbox: Newbie's Adventure (Switch)
- Uncanny Valley (Switch eShop)
- Unchained Blades (3DS eShop)
- Uncharted Waters: New Horizons (SNES)
- Undead Bowling (3DS eShop)
- Undead Horde (Switch eShop)
- Undead Storm Nightmare (3DS eShop)
- Underground (Wii U eShop)
- Undertale (Switch eShop)
- Underworld Ascendant (Switch eShop)
- Unepic (Wii U eShop)
- Unepic (Switch eShop)
- Unexplored (Switch eShop)
- Unholy Heights (3DS eShop)
- Unholy Heights (Switch eShop)
- Unicornicopia (Switch eShop)
- Uniracers (SNES)
- Unit 4 (Switch eShop)
- Unknown Fate (Switch eShop)
- Unlucky Mage (3DS eShop)
- UNO (WiiWare)
- UNO (DSiWare)
- UNO (Switch eShop)
- Unravel Two (Switch eShop)
- Unruly Heroes (Switch eShop)
- Unsolved Crimes (DS)
- Untitled Goose Game (Switch eShop)
- Unto The End (Switch eShop)
- Unworthy (Switch eShop)
- Up Up Bot (New 3DS)
- Urban Champion (NES)
- Urban Trial Freestyle (3DS eShop)
- Urban Trial Freestyle 2 (3DS eShop)
- Urban Trial Playground (Switch)
- Urbanix (WiiWare)
- Uridium (C64)
- Use Your Words (Wii U eShop)
- Use Your Words (Switch eShop)
- Ushiro (Switch eShop)
- UTOPIA 9 - A Volatile Vacation (Switch eShop)
- Uurnog Uurnlimited (Switch eShop)
- uWordsmith (Wii U eShop)