Blogs
An accomplished actor best known for his portrayal of Captain Benjamin “Hawkeye” Pierce in the US television series M*A*S*H, Alan Alda has taken on another impactful role in recent years: champion of science communication. Having served for 14 years as the host of Scientific American Frontiers, a public television show devoted to explaining recent advances in science and technology, in
A good catalytic system can feel like magic - if you can get high turnover and selectivity, small amounts of reagent can rip through vastly larger piles of starting materials, turning them into your products with speed and fidelity. That’s what enzymes accomplish (and are accomplishing now, as you read this, in every cell of your body). Living biochemistry just can’t work without havin
Rheumatoid arthritis is a complicated disease, as anyone who's tried to do drug discovery work in the area can verify. It's been recognized for a long time as an autoimmune disorder, but given the complexities of the human immune response, knowing that only takes you so far. Most of the therapies available are directed at turning down the immune/inflammation response in the joint tissues, and whil
Editor's Blog
An accomplished actor best known for his portrayal of Captain Benjamin “Hawkeye” Pierce in the US television series M*A*S*H, Alan Alda has taken on another impactful role in recent years: champion of science communication. Having served for 14 years as the host of Scientific American Frontiers, a public television show devoted to explaining recent advances in science and technology, in
Royce W. Murray, a pioneer in electrochemistry, chemically modified electrodes, self-assembled monolayers, and ionic liquids, died on 6 July at age 85. Much of how we think about modifying surfaces and measuring changes induced by those modifications comes from Murray’s lab. Murray’s scientific accomplishments have been enumerated elsewhere, but those who knew him will best remember hi
Ten years ago, an editorial in Science remarked on how little progress had been made on improving the postdoctoral experience since a landmark report in 2000 detailed the variability of such positions. Postdoctoral scholars (postdocs) are hardly better off in 2022; however, postdoctoral fellowship programs can serve as the nuclei for changes that have long been recognized as necessary for improvin
The past 2 years have been a period of mourning, anger, fear, and exhaustion for Asian Americans: 16% of Asian American adults were victims of hate crimes in 2021, up from 12.5% in 2020; 31% worry “all the time” or “often” about being victimized because of their race; and 36% have changed their routines over concerns about personal safety. Despite the increase in anti-Asian
Our food system is a rich, complex blend of biology and culture. From the biodiversity in forests, oceans, and farms to the living weave of long-standing traditions and emerging trends, food touches every aspect of life on Earth. This diversity hasn’t always carried through to agricultural and culinary literatures, but fortunately this is changing. Fresh perspectives are emerging in the lite
Three weeks ago, I wrote about how graduate education is still in serious need of reform and pointed to a NextGen Voices piece that we ran describing how principal investigators can be better mentors. Recently, I learned that two outstanding chemistry professors—Jen Heemstra at Emory University and Neil Garg at the University of California Los Angeles (UCLA)—had launched an initiative
Visuals
Have you ever wondered why some research makes science news and other research doesn’t? Of course, content is king but in addition to having significant findings, strong visuals can catch the attention of the press and larger audiences. It pays to spend some time taking high-quality photos of your work and putting them somewhere a photo editor (a person like me that seeks out pictures for news sto
I remember first learning about the nuclear pore. It was in high school biology, and I was immediately struck by how it looked. Its symmetry certainly stands out: eight copies of a protein unit arranged in a ring, encircling an opening in the nuclear membrane. And they cover the nucleus like holes in a colander (if that colander was very choosy about what it let through). The next thing one notice
Working with animals is unpredictable by nature. To them, there are always more interesting things to be doing, fresh smells to sniff, and new acquaintances to make. After reading the paper on dog breed stereotypes for the 29 April issue of Science, I knew we had to have a cover with as many dogs as possible. But if you’ve ever walked by a doggy daycare, you know it’s nearly impossible to get a group of dogs to focus on one thing, let alone sit still for a portrait.
I was fascinated by the complex shape of the intricate glass sculpture. Yet it was only 4.5 millimeters tall—less than the thickness of a No. 2 pencil. But the small scale posed a big problem: Would a photograph of such a minute object work as a Science cover?
In the Pipeline
A good catalytic system can feel like magic - if you can get high turnover and selectivity, small amounts of reagent can rip through vastly larger piles of starting materials, turning them into your products with speed and fidelity. That’s what enzymes accomplish (and are accomplishing now, as you read this, in every cell of your body). Living biochemistry just can’t work without havin
Rheumatoid arthritis is a complicated disease, as anyone who's tried to do drug discovery work in the area can verify. It's been recognized for a long time as an autoimmune disorder, but given the complexities of the human immune response, knowing that only takes you so far. Most of the therapies available are directed at turning down the immune/inflammation response in the joint tissues, and whil
This is a really interesting look at the current state of virtual screening, and it shows what I think it's best at doing right now: making the best of what we already know and what's new. It's from a large team of academic researchers (several departments across UCSF, Yale, UNC, Yonsei, Stanford, Duke, Washington U, Wisconsin, and Minas Gerais), and it's an attempt to find new subtype-select
Apolipoprotein E has generated many surprises over the years. I was working in the Alzheimer's field when it was discovered that a genetic variant of this one, APOE4, is a significant risk factor for Alzheimer's. There was a lot of speculation at the time for why this might be so, because it's not an obvious connection. ApoE carries cholesterol in the blood, and no one had really linked lipid hand
There’s a type of paper that I’ve seen in the literature for many years now, and always with some irritation. But since I’ve come across several examples just in the last week or so, I’m reached the activation threshold to actively complain about this stuff.
First these papers come up with some chemical matter, but not by directly screening against a specific target. Maybe
The cereblon protein naturally comes up every time I do a protein degradation post, and most of the time anyone talks about targeted protein degradation at all. That’s because it was part of the first “molecular glue” mechanism involving the ubiquitin ligase system, a discovery that illuminated the most terrible side effects of thalidomide dosing in humans. Later X-ray