Entry
Name
Perampanel hydrate (JAN); Fycompa (TN)
Product
Formula
(C23H15N3O)4. 3H2O
Exact mass
1450.5177
Mol weight
1451.58
Structure
Mol file KCF file DB search
Class
Neuropsychiatric agent
DG03199 Antiepileptic agent
DG01569 AMPA receptor antagonist
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
Remark
Therapeutic category: 1139
Product (DG01901): D10780<JP /US>
Efficacy
Antiepileptic, AMPA receptor antagonist
Target
Pathway
hsa04080 Neuroactive ligand-receptor interaction
Metabolism
Interaction
DDI search
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303 ]
N NERVOUS SYSTEM
N03 ANTIEPILEPTICS
N03A ANTIEPILEPTICS
N03AX Other antiepileptics
N03AX22 Perampanel
D10780 Perampanel hydrate (JAN) <JP/US>
USP drug classification [BR:br08302 ]
Anticonvulsants
Anticonvulsants, Other
Perampanel
D10780 Perampanel hydrate (JAN)
Therapeutic category of drugs in Japan [BR:br08301 ]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
113 Antiepileptics
1139 Others
D10780 Perampanel hydrate (JAN)
Drug groups [BR:br08330 ]
Neuropsychiatric agent
DG03199 Antiepileptic agent
DG01569 AMPA receptor antagonist
DG01901 Perampanel
D10780 Perampanel hydrate
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG01901 Perampanel
D10780 Perampanel hydrate
Drug classes [BR:br08332 ]
Neuropsychiatric agent
DG03199 Antiepileptic agent
D10780 Perampanel hydrate
Target-based classification of drugs [BR:br08310 ]
Ion channels
Ligand-gated ion channels
Glutamate (ionotropic), non-NMDA
GRIA
D10780 Perampanel hydrate (JAN) <JP/US>
New drug approvals in the USA [br08319.html ]
New molecular entities and new therapeutic biological products
D10780
New drug approvals in Europe [br08329.html ]
European public assessment reports (EPAR) authorised medicine
D10780
New drug approvals in Japan [br08318.html ]
Drugs with new active ingredients
D10780
New drug approvals in the USA, Europe and Japan [br08328.html ]
Approval dates by FDA, EMA and PMDA
D10780
Drug metabolizing enzymes and transporters [br08309.html ]
Drug metabolizing enzymes
D10780
Drug groups [BR:br08330 ]
Neuropsychiatric agent
DG03199 Antiepileptic agent
DG01569 AMPA receptor antagonist
DG01901 Perampanel
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG01901 Perampanel
BRITE hierarchy
Other DBs
LinkDB
All DBs
KCF data
Show ATOM 111
1 C8x C 10.7679 -12.1692
2 C8x C 10.7679 -13.5679
3 C8y C 12.0267 -14.2673
4 C8y C 13.2157 -13.5679
5 C8x C 13.2157 -12.1692
6 C8x C 12.0267 -11.4698
7 C8y C 14.4746 -14.3372
8 C8x C 14.4746 -15.7360
9 C8y C 15.6635 -16.4354
10 C8x C 16.8525 -15.7360
11 N4y N 16.8525 -14.3372
12 C8y C 15.6635 -13.6379
13 C3b C 12.0267 -15.7360
14 N3a N 12.0267 -17.1348
15 C8y C 18.1114 -13.6379
16 C8x C 19.3003 -14.2673
17 C8x C 20.4893 -13.5679
18 C8x C 20.4893 -12.1692
19 C8x C 19.3003 -11.4698
20 C8x C 18.1114 -12.1692
21 C8y C 15.6635 -17.8342
22 N5x N 14.4746 -18.4636
23 C8x C 14.4746 -19.8624
24 C8x C 15.6635 -20.5618
25 C8x C 16.8525 -19.9323
26 C8x C 16.8525 -18.5335
27 O5x O 15.6635 -12.1692
28 O0 O 25.6900 -16.6600
29 C8x C 10.7679 -12.1692
30 C8x C 10.7679 -13.5679
31 C8y C 12.0267 -14.2673
32 C8y C 13.2157 -13.5679
33 C8x C 13.2157 -12.1692
34 C8x C 12.0267 -11.4698
35 C8y C 14.4746 -14.3372
36 C8x C 14.4746 -15.7360
37 C8y C 15.6635 -16.4354
38 C8x C 16.8525 -15.7360
39 N4y N 16.8525 -14.3372
40 C8y C 15.6635 -13.6379
41 O5x O 15.6635 -12.1692
42 C8y C 18.1114 -13.6379
43 C8x C 19.3003 -14.2673
44 C8x C 20.4893 -13.5679
45 C8x C 20.4893 -12.1692
46 C8x C 19.3003 -11.4698
47 C8x C 18.1114 -12.1692
48 C8y C 15.6635 -17.8342
49 N5x N 14.4746 -18.4636
50 C8x C 14.4746 -19.8624
51 C8x C 15.6635 -20.5618
52 C8x C 16.8525 -19.9323
53 C8x C 16.8525 -18.5335
54 C3b C 12.0267 -15.7360
55 N3a N 12.0267 -17.1348
56 C8x C 10.7679 -12.1692
57 C8x C 10.7679 -13.5679
58 C8y C 12.0267 -14.2673
59 C8y C 13.2157 -13.5679
60 C8x C 13.2157 -12.1692
61 C8x C 12.0267 -11.4698
62 C8y C 14.4746 -14.3372
63 C8x C 14.4746 -15.7360
64 C8y C 15.6635 -16.4354
65 C8x C 16.8525 -15.7360
66 N4y N 16.8525 -14.3372
67 C8y C 15.6635 -13.6379
68 O5x O 15.6635 -12.1692
69 C8y C 18.1114 -13.6379
70 C8x C 19.3003 -14.2673
71 C8x C 20.4893 -13.5679
72 C8x C 20.4893 -12.1692
73 C8x C 19.3003 -11.4698
74 C8x C 18.1114 -12.1692
75 C8y C 15.6635 -17.8342
76 N5x N 14.4746 -18.4636
77 C8x C 14.4746 -19.8624
78 C8x C 15.6635 -20.5618
79 C8x C 16.8525 -19.9323
80 C8x C 16.8525 -18.5335
81 C3b C 12.0267 -15.7360
82 N3a N 12.0267 -17.1348
83 C8x C 10.7679 -12.1692
84 C8x C 10.7679 -13.5679
85 C8y C 12.0267 -14.2673
86 C8y C 13.2157 -13.5679
87 C8x C 13.2157 -12.1692
88 C8x C 12.0267 -11.4698
89 C8y C 14.4746 -14.3372
90 C8x C 14.4746 -15.7360
91 C8y C 15.6635 -16.4354
92 C8x C 16.8525 -15.7360
93 N4y N 16.8525 -14.3372
94 C8y C 15.6635 -13.6379
95 O5x O 15.6635 -12.1692
96 C8y C 18.1114 -13.6379
97 C8x C 19.3003 -14.2673
98 C8x C 20.4893 -13.5679
99 C8x C 20.4893 -12.1692
100 C8x C 19.3003 -11.4698
101 C8x C 18.1114 -12.1692
102 C8y C 15.6635 -17.8342
103 N5x N 14.4746 -18.4636
104 C8x C 14.4746 -19.8624
105 C8x C 15.6635 -20.5618
106 C8x C 16.8525 -19.9323
107 C8x C 16.8525 -18.5335
108 C3b C 12.0267 -15.7360
109 N3a N 12.0267 -17.1348
110 O0 O 25.6900 -16.6600
111 O0 O 25.6900 -16.6600
BOND 120
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 4 7 1
8 7 8 2
9 8 9 1
10 9 10 2
11 10 11 1
12 11 12 1
13 7 12 1
14 3 13 1
15 13 14 3
16 11 15 1
17 15 16 2
18 16 17 1
19 17 18 2
20 18 19 1
21 19 20 2
22 15 20 1
23 9 21 1
24 21 22 2
25 22 23 1
26 23 24 2
27 24 25 1
28 25 26 2
29 21 26 1
30 12 27 2
31 29 30 2
32 30 31 1
33 31 32 2
34 32 33 1
35 33 34 2
36 29 34 1
37 32 35 1
38 35 36 2
39 36 37 1
40 37 38 2
41 38 39 1
42 39 40 1
43 35 40 1
44 31 54 1
45 54 55 3
46 39 42 1
47 42 43 2
48 43 44 1
49 44 45 2
50 45 46 1
51 46 47 2
52 42 47 1
53 37 48 1
54 48 49 2
55 49 50 1
56 50 51 2
57 51 52 1
58 52 53 2
59 48 53 1
60 40 41 2
61 56 57 2
62 57 58 1
63 58 59 2
64 59 60 1
65 60 61 2
66 56 61 1
67 59 62 1
68 62 63 2
69 63 64 1
70 64 65 2
71 65 66 1
72 66 67 1
73 62 67 1
74 58 81 1
75 81 82 3
76 66 69 1
77 69 70 2
78 70 71 1
79 71 72 2
80 72 73 1
81 73 74 2
82 69 74 1
83 64 75 1
84 75 76 2
85 76 77 1
86 77 78 2
87 78 79 1
88 79 80 2
89 75 80 1
90 67 68 2
91 83 84 2
92 84 85 1
93 85 86 2
94 86 87 1
95 87 88 2
96 83 88 1
97 86 89 1
98 89 90 2
99 90 91 1
100 91 92 2
101 92 93 1
102 93 94 1
103 89 94 1
104 85 108 1
105 108 109 3
106 93 96 1
107 96 97 2
108 97 98 1
109 98 99 2
110 99 100 1
111 100 101 2
112 96 101 1
113 91 102 1
114 102 103 2
115 103 104 1
116 104 105 2
117 105 106 1
118 106 107 2
119 102 107 1
120 94 95 2
BRACKET 1 10.0800 -21.0700 10.0800 -10.8500
1 20.9300 -10.8500 20.9300 -21.0700
1 4
ORIGINAL 1 1 2 3 4 5 6 7 8 9 10 11 12 27 15 16 17
1 18 19 20 21 22 23 24 25 26 13 14
REPEAT 1 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44
1 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60
1 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76
1 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92
1 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108
1 109
2 23.5200 -17.6400 23.5200 -15.5400
2 26.6700 -15.5400 26.6700 -17.6400
2 3
ORIGINAL 2 28
REPEAT 2 110 111