| Entry |
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| Name |
Atorvastatin calcium propylene glycol solvate |
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| Product |
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| Generic |
ATORVASTATIN CALCIUM (A-S Medication Solutions), ATORVASTATIN CALCIUM (A-S Medication Solutions), ATORVASTATIN CALCIUM (A-S Medication Solutions), ATORVASTATIN CALCIUM (A-S Medication Solutions), ATORVASTATIN CALCIUM (A-S Medication Solutions), ATORVASTATIN CALCIUM (A-S Medication Solutions), ATORVASTATIN CALCIUM (A-S Medication Solutions), ATORVASTATIN CALCIUM (A-S Medication Solutions), ATORVASTATIN CALCIUM (Aphena Pharma Solutions - Tennessee), ATORVASTATIN CALCIUM (Aphena Pharma Solutions - Tennessee), ATORVASTATIN CALCIUM (Apotex Corp.), ATORVASTATIN CALCIUM (AvPAK), ATORVASTATIN CALCIUM (Bryant Ranch Prepack), ATORVASTATIN CALCIUM (Bryant Ranch Prepack), ATORVASTATIN CALCIUM (Cardinal Health 107), ATORVASTATIN CALCIUM (Cardinal Health 107), ATORVASTATIN CALCIUM (Cardinal Health 107), ATORVASTATIN CALCIUM (Cardinal Health 107), ATORVASTATIN CALCIUM (Denton Pharma), ATORVASTATIN CALCIUM (Major Pharmaceuticals), ATORVASTATIN CALCIUM (Major Pharmaceuticals), ATORVASTATIN CALCIUM (NCS HealthCare of KY), ATORVASTATIN CALCIUM (NCS HealthCare of KY), ATORVASTATIN CALCIUM (NCS HealthCare of KY), ATORVASTATIN CALCIUM (NORTHSTAR RX LLC), ATORVASTATIN CALCIUM (Northwind Pharmaceuticals), ATORVASTATIN CALCIUM (Northwind Pharmaceuticals), ATORVASTATIN CALCIUM (Northwind Pharmaceuticals), ATORVASTATIN CALCIUM (Northwind Pharmaceuticals), ATORVASTATIN CALCIUM (NuCare Pharmaceuticals), ATORVASTATIN CALCIUM (NuCare Pharmaceuticals), ATORVASTATIN CALCIUM (PD-Rx Pharmaceuticals), ATORVASTATIN CALCIUM (PD-Rx Pharmaceuticals), ATORVASTATIN CALCIUM (Proficient Rx LP), ATORVASTATIN CALCIUM (Proficient Rx LP), ATORVASTATIN CALCIUM (QPharma), ATORVASTATIN CALCIUM (QPharma), ATORVASTATIN CALCIUM (Quallent), ATORVASTATIN CALCIUM (REMEDYREPACK), ATORVASTATIN CALCIUM (REMEDYREPACK), ATORVASTATIN CALCIUM (REMEDYREPACK), ATORVASTATIN CALCIUM (REMEDYREPACK) |
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| Formula |
(C33H34FN2O5)2. C3H8O2. Ca
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| Exact mass |
1230.5054
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| Mol weight |
1231.43
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| Structure |
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| Simcomp |
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| Class |
Hypolipidemic agent
DG01946 Hypolipidemic agent
DG01660 HMG-CoA reductase inhibitor
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
Transporter substrate
DG01665 ABCB1 substrate
DG01913 ABCG2 substrate
DG02856 SLCO1B1 substrate
DG02932 SLCO1B3 substrate
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| Remark |
| Product (DG00355): | D07474<US> D02258<JP/US> D11095<US> |
| Product (mixture): | D08488<JP/US> |
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| Efficacy |
Antihyperlipidemic, HMG-CoA reductase inhibitor |
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| Disease |
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| Target |
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| Pathway |
| hsa00900 | Terpenoid backbone biosynthesis |
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
Transporter: ABCB1 [HSA: 5243], ABCG2 [HSA: 9429], SLCO1B1 [HSA: 10599], SLCO1B3 [HSA: 28234]
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| Interaction |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C10 LIPID MODIFYING AGENTS
C10A LIPID MODIFYING AGENTS, PLAIN
C10AA HMG CoA reductase inhibitors
C10AA05 Atorvastatin
D11095 Atorvastatin calcium propylene glycol solvate <US>
USP drug classification [BR:br08302]
Cardiovascular Agents
Dyslipidemics, HMG CoA Reductase Inhibitors
Atorvastatin
D11095 Atorvastatin calcium propylene glycol solvate
Drug groups [BR:br08330]
Hypolipidemic agent
DG01946 Hypolipidemic agent
DG01660 HMG-CoA reductase inhibitor
DG00355 Atorvastatin
D11095 Atorvastatin calcium propylene glycol solvate
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00355 Atorvastatin
D11095 Atorvastatin calcium propylene glycol solvate
Transporter substrate
DG01665 ABCB1 substrate
DG00355 Atorvastatin
D11095 Atorvastatin calcium propylene glycol solvate
DG01913 ABCG2 substrate
DG00355 Atorvastatin
D11095 Atorvastatin calcium propylene glycol solvate
DG02856 SLCO1B1 substrate
DG00355 Atorvastatin
D11095 Atorvastatin calcium propylene glycol solvate
DG02932 SLCO1B3 substrate
DG00355 Atorvastatin
D11095 Atorvastatin calcium propylene glycol solvate
Drug classes [BR:br08332]
Cardiovascular agent
DG01946 Hypolipidemic agent
D11095 Atorvastatin calcium propylene glycol solvate
Target-based classification of drugs [BR:br08310]
Enzymes
Oxidoreductases (EC1)
Dehydrogenases
HMGCR
D11095 Atorvastatin calcium propylene glycol solvate <US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D11095
Drug transporters
D11095
Drug groups [BR:br08330]
Hypolipidemic agent
DG01946 Hypolipidemic agent
DG01660 HMG-CoA reductase inhibitor
DG00355 Atorvastatin
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00355 Atorvastatin
Transporter substrate
DG01665 ABCB1 substrate
DG00355 Atorvastatin
DG01913 ABCG2 substrate
DG00355 Atorvastatin
DG02856 SLCO1B1 substrate
DG00355 Atorvastatin
DG02932 SLCO1B3 substrate
DG00355 Atorvastatin
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 88
1 C8y C 18.0600 -19.0400
2 C8y C 19.4600 -19.0400
3 C8y C 19.8800 -17.7100
4 N4y N 18.7600 -16.9400
5 C8y C 17.5700 -17.7100
6 C8y C 17.2200 -20.1600
7 C1c C 21.2100 -17.2900
8 C8y C 16.3100 -17.2900
9 C1b C 18.7600 -15.5400
10 C1b C 19.9500 -14.8400
11 C1c C 19.9500 -13.4400
12 O1a O 21.2100 -12.7400
13 C1b C 18.7600 -12.7400
14 C1c C 18.7600 -11.3400
15 C1b C 19.9500 -10.6400
16 O1a O 17.5700 -10.6400
17 C6a C 21.3500 -10.6400
18 O6a O 22.0500 -11.8300 #-
19 O6a O 22.0500 -9.3800
20 C8x C 16.0300 -15.8900
21 C8x C 14.6300 -15.4700
22 C8y C 13.6500 -16.3800
23 C8x C 13.9300 -17.7800
24 C8x C 15.2600 -18.2000
25 C1a C 22.2600 -18.2000
26 C1a C 21.4900 -15.8900
27 X F 12.2500 -15.9600
28 C5a C 20.3000 -20.1600
29 N1b N 21.7000 -20.1600
30 O5a O 19.6700 -21.4200
31 C8y C 22.4000 -21.3500
32 C8x C 21.7000 -22.5400
33 C8x C 22.4000 -23.7300
34 C8x C 23.8000 -23.7300
35 C8x C 24.4300 -22.6100
36 C8x C 23.7300 -21.3500
37 C8x C 15.8200 -20.1600
38 C8x C 15.0500 -21.2800
39 C8x C 15.6800 -22.6100
40 C8x C 17.0800 -22.6100
41 C8x C 17.8500 -21.4200
42 Z Ca 26.4600 -11.6900 #2+
43 C1a C 27.7200 -18.1300
44 C1c C 28.9324 -18.8300
45 C1b C 30.1279 -18.1396
46 O1a O 28.9325 -20.2298
47 O1a O 31.3153 -18.8251
48 C8y C 18.0600 -19.0400
49 C8y C 19.4600 -19.0400
50 C8y C 19.8800 -17.7100
51 N4y N 18.7600 -16.9400
52 C8y C 17.5700 -17.7100
53 C8y C 16.3100 -17.2900
54 C8x C 16.0300 -15.8900
55 C8x C 14.6300 -15.4700
56 C8y C 13.6500 -16.3800
57 C8x C 13.9300 -17.7800
58 C8x C 15.2600 -18.2000
59 X F 12.2500 -15.9600
60 C1b C 18.7600 -15.5400
61 C1b C 19.9500 -14.8400
62 C1c C 19.9500 -13.4400
63 O1a O 21.2100 -12.7400
64 C1b C 18.7600 -12.7400
65 C1c C 18.7600 -11.3400
66 C1b C 19.9500 -10.6400
67 C6a C 21.3500 -10.6400
68 O6a O 22.0500 -11.8300 #-
69 O6a O 22.0500 -9.3800
70 O1a O 17.5700 -10.6400
71 C1c C 21.2100 -17.2900
72 C1a C 22.2600 -18.2000
73 C1a C 21.4900 -15.8900
74 C5a C 20.3000 -20.1600
75 N1b N 21.7000 -20.1600
76 C8y C 22.4000 -21.3500
77 C8x C 21.7000 -22.5400
78 C8x C 22.4000 -23.7300
79 C8x C 23.8000 -23.7300
80 C8x C 24.4300 -22.6100
81 C8x C 23.7300 -21.3500
82 O5a O 19.6700 -21.4200
83 C8y C 17.2200 -20.1600
84 C8x C 15.8200 -20.1600
85 C8x C 15.0500 -21.2800
86 C8x C 15.6800 -22.6100
87 C8x C 17.0800 -22.6100
88 C8x C 17.8500 -21.4200
BOND 92
1 43 44 1
2 44 45 1
3 44 46 1
4 45 47 1
5 1 2 1
6 2 3 2
7 3 4 1
8 4 5 1
9 1 5 2
10 1 6 1
11 3 7 1
12 5 8 1
13 4 9 1
14 9 10 1
15 11 10 1 #Down
16 11 12 1
17 11 13 1
18 13 14 1
19 14 15 1
20 14 16 1 #Up
21 15 17 1
22 17 18 1
23 17 19 2
24 8 20 2
25 20 21 1
26 21 22 2
27 22 23 1
28 23 24 2
29 8 24 1
30 7 25 1
31 7 26 1
32 22 27 1
33 2 28 1
34 28 29 1
35 28 30 2
36 29 31 1
37 31 32 2
38 32 33 1
39 33 34 2
40 34 35 1
41 35 36 2
42 31 36 1
43 6 37 2
44 37 38 1
45 38 39 2
46 39 40 1
47 40 41 2
48 6 41 1
49 48 49 1
50 49 50 2
51 50 51 1
52 51 52 1
53 48 52 2
54 48 83 1
55 50 71 1
56 52 53 1
57 51 60 1
58 60 61 1
59 62 61 1 #Down
60 62 63 1
61 62 64 1
62 64 65 1
63 65 66 1
64 65 70 1 #Up
65 66 67 1
66 67 68 1
67 67 69 2
68 53 54 2
69 54 55 1
70 55 56 2
71 56 57 1
72 57 58 2
73 53 58 1
74 71 72 1
75 71 73 1
76 56 59 1
77 49 74 1
78 74 75 1
79 74 82 2
80 75 76 1
81 76 77 2
82 77 78 1
83 78 79 2
84 79 80 1
85 80 81 2
86 76 81 1
87 83 84 2
88 84 85 1
89 85 86 2
90 86 87 1
91 87 88 2
92 83 88 1
BRACKET 1 11.4800 -23.8700 11.4800 -8.5400
1 24.5000 -8.5400 24.5000 -23.8700
1 2
ORIGINAL 1 1 2 3 4 5 8 20 21 22 23 24 27 9 10 11 12
1 13 14 15 17 18 19 16 7 25 26 28 29 31 32 33 34
1 35 36 30 6 37 38 39 40 41
REPEAT 1 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63
1 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79
1 80 81 82 83 84 85 86 87 88
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