KEGG ORTHOLOGY: K04503

ORTHOLOGY: K04503

Entry

K04503                      KO

Symbol

CCND1

Name

G1/S-specific cyclin-D1

Pathway

map01522

Endocrine resistance

map04068

FoxO signaling pathway

map04110

Cell cycle

map04115

p53 signaling pathway

map04151

PI3K-Akt signaling pathway

map04152

AMPK signaling pathway

map04218

Cellular senescence

map04310

Wnt signaling pathway

map04340

Hedgehog signaling pathway

map04371

Apelin signaling pathway

map04390

Hippo signaling pathway

map04510

Focal adhesion

map04530

Tight junction

map04630

JAK-STAT signaling pathway

map04917

Prolactin signaling pathway

map04919

Thyroid hormone signaling pathway

map04921

Oxytocin signaling pathway

map04933

AGE-RAGE signaling pathway in diabetic complications

map04934

Cushing syndrome

map04936

Alcoholic liver disease

map05160

Hepatitis C

map05162

Measles

map05163

Human cytomegalovirus infection

map05165

Human papillomavirus infection

map05166

Human T-cell leukemia virus 1 infection

map05167

Kaposi sarcoma-associated herpesvirus infection

map05169

Epstein-Barr virus infection

map05200

Pathways in cancer

map05203

Viral carcinogenesis

map05205

Proteoglycans in cancer

map05206

MicroRNAs in cancer

map05207

Chemical carcinogenesis - receptor activation

map05210

Colorectal cancer

map05212

Pancreatic cancer

map05213

Endometrial cancer

map05214

Glioma

map05215

Prostate cancer

map05216

Thyroid cancer

map05218

Melanoma

map05219

Bladder cancer

map05220

Chronic myeloid leukemia

map05221

Acute myeloid leukemia

map05222

Small cell lung cancer

map05223

Non-small cell lung cancer

map05224

Breast cancer

map05225

Hepatocellular carcinoma

map05226

Gastric cancer

map05416

Viral myocarditis

Disease

H00006

Hairy cell leukemia

H00010

Multiple myeloma

H00016

Oral cancer

H00017

Esophageal cancer

H00020

Colorectal cancer

H00031

Breast cancer

H00055

Laryngeal cancer

H00559

von Hippel-Lindau syndrome

H01464

Mantle cell lymphoma

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    K04503  CCND1; G1/S-specific cyclin-D1
   04340 Hedgehog signaling pathway
    K04503  CCND1; G1/S-specific cyclin-D1
   04390 Hippo signaling pathway
    K04503  CCND1; G1/S-specific cyclin-D1
   04371 Apelin signaling pathway
    K04503  CCND1; G1/S-specific cyclin-D1
   04630 JAK-STAT signaling pathway
    K04503  CCND1; G1/S-specific cyclin-D1
   04068 FoxO signaling pathway
    K04503  CCND1; G1/S-specific cyclin-D1
   04151 PI3K-Akt signaling pathway
    K04503  CCND1; G1/S-specific cyclin-D1
   04152 AMPK signaling pathway
    K04503  CCND1; G1/S-specific cyclin-D1
09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    K04503  CCND1; G1/S-specific cyclin-D1
   04115 p53 signaling pathway
    K04503  CCND1; G1/S-specific cyclin-D1
   04218 Cellular senescence
    K04503  CCND1; G1/S-specific cyclin-D1
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K04503  CCND1; G1/S-specific cyclin-D1
   04530 Tight junction
    K04503  CCND1; G1/S-specific cyclin-D1
09150 Organismal Systems
  09152 Endocrine system
   04917 Prolactin signaling pathway
    K04503  CCND1; G1/S-specific cyclin-D1
   04921 Oxytocin signaling pathway
    K04503  CCND1; G1/S-specific cyclin-D1
   04919 Thyroid hormone signaling pathway
    K04503  CCND1; G1/S-specific cyclin-D1
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04503  CCND1; G1/S-specific cyclin-D1
   05206 MicroRNAs in cancer
    K04503  CCND1; G1/S-specific cyclin-D1
   05205 Proteoglycans in cancer
    K04503  CCND1; G1/S-specific cyclin-D1
   05207 Chemical carcinogenesis - receptor activation
    K04503  CCND1; G1/S-specific cyclin-D1
   05203 Viral carcinogenesis
    K04503  CCND1; G1/S-specific cyclin-D1
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04503  CCND1; G1/S-specific cyclin-D1
   05212 Pancreatic cancer
    K04503  CCND1; G1/S-specific cyclin-D1
   05225 Hepatocellular carcinoma
    K04503  CCND1; G1/S-specific cyclin-D1
   05226 Gastric cancer
    K04503  CCND1; G1/S-specific cyclin-D1
   05214 Glioma
    K04503  CCND1; G1/S-specific cyclin-D1
   05216 Thyroid cancer
    K04503  CCND1; G1/S-specific cyclin-D1
   05221 Acute myeloid leukemia
    K04503  CCND1; G1/S-specific cyclin-D1
   05220 Chronic myeloid leukemia
    K04503  CCND1; G1/S-specific cyclin-D1
   05218 Melanoma
    K04503  CCND1; G1/S-specific cyclin-D1
   05219 Bladder cancer
    K04503  CCND1; G1/S-specific cyclin-D1
   05215 Prostate cancer
    K04503  CCND1; G1/S-specific cyclin-D1
   05213 Endometrial cancer
    K04503  CCND1; G1/S-specific cyclin-D1
   05224 Breast cancer
    K04503  CCND1; G1/S-specific cyclin-D1
   05222 Small cell lung cancer
    K04503  CCND1; G1/S-specific cyclin-D1
   05223 Non-small cell lung cancer
    K04503  CCND1; G1/S-specific cyclin-D1
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04503  CCND1; G1/S-specific cyclin-D1
   05160 Hepatitis C
    K04503  CCND1; G1/S-specific cyclin-D1
   05162 Measles
    K04503  CCND1; G1/S-specific cyclin-D1
   05163 Human cytomegalovirus infection
    K04503  CCND1; G1/S-specific cyclin-D1
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04503  CCND1; G1/S-specific cyclin-D1
   05169 Epstein-Barr virus infection
    K04503  CCND1; G1/S-specific cyclin-D1
   05165 Human papillomavirus infection
    K04503  CCND1; G1/S-specific cyclin-D1
  09166 Cardiovascular disease
   05416 Viral myocarditis
    K04503  CCND1; G1/S-specific cyclin-D1
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K04503  CCND1; G1/S-specific cyclin-D1
   04933 AGE-RAGE signaling pathway in diabetic complications
    K04503  CCND1; G1/S-specific cyclin-D1
   04934 Cushing syndrome
    K04503  CCND1; G1/S-specific cyclin-D1
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    K04503  CCND1; G1/S-specific cyclin-D1

Genes

HSA:	595(CCND1)

PTR:	747442(CCND1)

PPS:	100995605(CCND1)

GGO:	101130447(CCND1) 101144860

PON:	100171625(CCND1)

PPYG:

129008462(CCND1)

NLE:	100605736(CCND1)

HMH:	116469117(CCND1)

SSYN:

129478909(CCND1)

MCC:	574320(CCND1)

MCF:	102135329(CCND1)

MTHB:

126935963

MNI:	105469727(CCND1)

CSAB:

103246489(CCND1)

CATY:

105577306(CCND1)

PANU:

101019923(CCND1)

TGE:	112605640(CCND1)

MLEU:

105544506(CCND1)

RRO:	104677168(CCND1)

RBB:	108538745(CCND1)

TFN:	117081518(CCND1)

PTEH:

111522272(CCND1)

CANG:

105512055(CCND1)

CJC:	103796419(CCND1)

SBQ:	101047858(CCND1)

CIMI:

108294139(CCND1)

ANAN:

105717648(CCND1)

CSYR:

103252197(CCND1)

MMUR:

105867511(CCND1)

LCAT:

123642799(CCND1)

PCOQ:

105827423(CCND1)

OGA:	100958947(CCND1)

MMU:	12443(Ccnd1)

MCAL:

110298189(Ccnd1)

MPAH:

110322378(Ccnd1)

RNO:	58919(Ccnd1)

MCOC:

116103285(Ccnd1)

ANU:	117711496(Ccnd1)

MUN:	110546940(Ccnd1)

CGE:	100689063(Ccnd1)

MAUA:

101837554(Ccnd1)

PROB:

127228599(Ccnd1)

PLEU:

114694498(Ccnd1)

MORG:

121454505(Ccnd1) 121457865

MFOT:

126498427

AAMP:

119827335(Ccnd1)

NGI:	103751498(Ccnd1)

HGL:	101712621(Ccnd1)

CPOC:

100729808(Ccnd1)

CCAN:

109696351(Ccnd1)

DORD:

105989065(Ccnd1)

DSP:	122099882(Ccnd1)

PLOP:

125362637(Ccnd1)

NCAR:

124958520

MMMA:

107156886(Ccnd1)

OPI:	101531631(CCND1)

TUP:	102490651(CCND1)

GVR:	103607082(CCND1)

CFA:	449028(CCND1)

CLUD:

112663184(CCND1)

VVP:	112924157(CCND1)

VLG:	121501724(CCND1)

NPO:	129502968(CCND1)

AML:	100469787(CCND1)

UMR:	103671139(CCND1)

UAH:	113243982(CCND1)

UAR:	123778441(CCND1)

ELK:

111149458

LLV:

125078419

MPUF:

101670844(CCND1)

MNP:	132017399(CCND1)

MLK:	131817001(CCND1)

NVS:	122913270(CCND1)

ORO:	101371532(CCND1)

EJU:	114220310(CCND1)

ZCA:	113914083(CCND1)

MLX:	118016166(CCND1)

NSU:	110576391(CCND1)

LWW:	102747216(CCND1)

FCA:	100037407(CCND1)

PYU:	121023852(CCND1)

PBG:	122484101(CCND1)

PVIV:

125176918(CCND1)

LRUF:

124506147

PTG:	102959906(CCND1)

PPAD:

109246902(CCND1)

PUC:

125930010

AJU:

106971167

HHV:	120233874(CCND1)

BTA:	524530(CCND1)

BOM:	102270546(CCND1)

BIU:	109554439(CCND1)

BBUB:

102411133(CCND1)

BBIS:

104987056(CCND1)

CHX:	102169650(CCND1)

OAS:	100144763(CCND1)

BTAX:

128069030(CCND1)

ODA:	120874144(CCND1)

CCAD:

122430666(CCND1)

MBEZ:

129548664(CCND1)

SSC:	100738589(CCND1)

CFR:	102518309(CCND1)

CBAI:

105070367(CCND1)

CDK:	105104393(CCND1)

VPC:	102529872(CCND1)

BACU:

103013404(CCND1)

BMUS:

118898958(CCND1)

LVE:	103090612(CCND1)

OOR:	101273294(CCND1)

DLE:	111183632(CCND1)

PCAD:

102996914(CCND1)

PSIU:

116757387(CCND1)

NASI:

112402178(CCND1)

ECB:	102149114(CCND1)

EAI:	106844248(CCND1)

MYB:	102263484(CCND1)

MYD:	102759793(CCND1)

MMYO:

118665181(CCND1)

MLF:	102441858(CCND1)

MDT:	132241301(CCND1)

PKL:	118712764(CCND1)

EFUS:

103290903(CCND1)

MNA:	107537434(CCND1)

DRO:	112317273(CCND1)

SHON:

118998396(CCND1)

AJM:	119041888(CCND1)

PDIC:

114500683(CCND1)

PHAS:

123829562(CCND1)

MMF:	118628257(CCND1)

PPAM:

129068523(CCND1)

HAI:	109389297(CCND1)

RFQ:	117030194(CCND1)

PALE:

102885330(CCND1)

PGIG:

120584714(CCND1)

PVP:

105307128

RAY:	107503391(CCND1)

MJV:	108388480(CCND1)

TOD:	119246910 119249876(CCND1)

SARA:

101555422(CCND1)

SETR:

126019074(CCND1)

LAV:	100669703(CCND1)

TMU:

101359745

ETF:	101657154(CCND1)

DNM:	101420648(CCND1)

MDO:	100013257(CCND1)

SHR:	100917462(CCND1)

AFZ:

127539835

PCW:	110197171(CCND1)

TVP:	118852949(CCND1)

OAA:	100075081(CCND1)

GGA:	396341(CCND1)

PCOC:

116229085(CCND1)

MGP:	100539759(CCND1)

CJO:	107314428(CCND1)

TPAI:

128086508(CCND1)

LMUT:

125694598(CCND1)

NMEL:

110400907(CCND1)

APLA:

101800639(CCND1)

ACYG:

106044779(CCND1)

CATA:

118250840(CCND1)

AFUL:

116490240(CCND1)

TGU:	100231612(CCND1)

LSR:	110469631(CCND1)

SCAN:

103822217(CCND1)

PMOA:

120509851(CCND1)

OTC:	121339534(CCND1)

PRUF:

121349085(CCND1)

GFR:	102042858(CCND1)

FAB:	101807319(CCND1)

OMA:	130253512(CCND1)

PHI:	102099659(CCND1)

PMAJ:

107205992(CCND1)

CCAE:

111930656(CCND1)

CCW:	104697629(CCND1)

CBRC:

103614709(CCND1)

ETL:	114067926(CCND1)

ZAB:	102063435(CCND1)

ZLE:	135449047(CCND1)

ACHL:

103810712(CCND1)

SVG:	106854769(CCND1)

MMEA:

130577556(CCND1)

HRT:	120754042(CCND1)

SATI:

136362158(CCND1)

FPG:	101914937(CCND1)

FCH:	102053036(CCND1)

CCRI:

104156601(CCND1)

SHAB:

115607412(CCND1)

ACUN:

113481227(CCND1)

TALA:

104362598(CCND1)

ACHC:

115351476(CCND1)

HLE:	104829446(CCND1)

AGEN:

126046852

GCL:

127017416

CSTI:

104552006(CCND1)

LDI:	104341693(CCND1)

MNB:	103774835(CCND1)

DPUB:

104297509(CCND1)

AVIT:

104269354(CCND1)

BRHI:

104488602(CCND1)

EGZ:	104124693(CCND1)

NNI:	104009408(CCND1)

PCRI:

104029611(CCND1)

PCAO:

104051640(CCND1)

PADL:

103925769(CCND1)

AFOR:

103904929(CCND1)

FGA:	104077968(CCND1)

GSTE:

104260603(CCND1)

CLV:	102086245(CCND1)

MUI:	104535334(CCND1)

PGUU:

104471418(CCND1)

PLET:

104617292(CCND1)

CMAC:

104475027(CCND1)

CUCA:

104062258(CCND1)

TEO:	104371160(CCND1)

BREG:

104633930(CCND1)

OHA:	104330745(CCND1)

ACAR:

104527158(CCND1)

CPEA:

104397465(CCND1)

CVF:	104287532(CCND1)

RTD:	128908362(CCND1)

AAM:	106498229(CCND1)

AROW:

112977236(CCND1)

NPD:	112943487(CCND1)

TGT:	104576329(CCND1)

DNE:	112979968(CCND1)

SCAM:

104152854(CCND1)

ASN:	102378816(CCND1)

AMJ:	102563714(CCND1)

CPOO:

109321196(CCND1)

GGN:	109298996(CCND1)

PSS:	102457993(CCND1)

CMY:	102947923(CCND1)

CCAY:

125638229(CCND1)

DCC:	119858104(CCND1)

CPIC:

101943958(CCND1)

TST:	117877043(CCND1)

CABI:

116819583(CCND1)

MRV:	120403684(CCND1)

ACS:	100563772(ccnd1)

ASAO:

132768969(CCND1)

PVT:	110073542(CCND1)

SUND:

121933704(CCND1)

PBI:	103066913(CCND1)

PMUR:

107285821(CCND1)

CTIG:

120316170(CCND1)

TSR:	106546690(CCND1)

PGUT:

117665432(CCND1)

APRI:

131187188(CCND1)

PTEX:

113440315(CCND1)

NSS:	113410261(CCND1)

VKO:	123026251(CCND1)

PMUA:

114596879(CCND1)

PRAF:

128414074(CCND1)

ZVI:	118085960(CCND1)

HCG:	128339433(CCND1)

GJA:	107121511(CCND1)

STOW:

125426154(CCND1)

EMC:	129324627(CCND1)

XLA:	379161(ccnd1.S) 379937(ccnd1.L) 447541 447748(ccndx.L)

XTR:	448045(ccnd1) 548862(ccndx)

NPR:	108785450(CCND1) 108793412

RTEM:

120916056 120917108(CCND1)

BBUF:

120980269(CCND1) 121002136

BGAR:

122920343(CCND1) 122926689

MUO:	115465024 115468768(CCND1)

GSH:	117352052(CCND1) 117368684

DRE:	30222(ccnd1)

SRX:	107727103 107730086

SANH:

107679730 107686820

SGH:	107584710 107594473

CCAR:

109093191(ccnd1)

CAUA:

113051788 113106505

CGIB:

127962195 128016536

PTET:

122348942(ccnd1)

LROH:

127168605(ccnd1)

OMC:	131544494(ccnd1)

PPRM:

120492676(ccnd1)

RKG:	130097285(ccnd1)

MAMB:

125265759(ccnd1)

CIDE:

127516057

CERY:

137030079(ccnd1)

MASI:

127412072 127440653

TROS:

130559793(ccnd1)

TDW:	130424833(ccnd1)

MANU:

129451283(ccnd1)

IPU:

108271119

IFU:	128614260(ccnd1)

PHYP:

113536429(ccnd1)

SMEO:

124391126(ccnd1)

TFD:	113646732(ccnd1)

TVC:	132856637(ccnd1)

TRN:	134331542(ccnd1)

AMEXあめっくす:

103031956(ccnd1)

CMAO:

118818888(ccnd1)

EEE:	113578962(ccnd1) 113588422

CHAR:

105911298(ccnd1)

TRU:	101061278(ccnd1)

TFS:	130536034(ccnd1)

TNG:	GSTEN00026524G001

LCO:	104937240(ccnd1) 104939589

NCC:	104950786(ccnd1) 104967413

TBEN:

117491260 117496472(ccnd1)

CGOB:

115004643(ccnd1) 115009127

PGEO:

117441044 117448201(ccnd1)

GACU:

117532640 117557335(ccnd1)

EMAC:

134863518(ccnd1) 134882412

ELY:	117257798(ccnd1) 117261946

EFO:	125887563 125902738(ccnd1)

PLEP:

121950245(ccnd1) 121964485 121964884

SLUC:

116040204 116041081(ccnd1)

ECRA:

117946450(ccnd1) 117948766

ESP:	116694578 116703178(ccnd1)

PFLV:

114552928(ccnd1) 114560618

GAT:	120812234(ccnd1) 120812565 120812806

PPUG:

119196637 119196950(ccnd1)

AFB:	129102238(ccnd1) 129108229

CLUM:

117727345(ccnd1) 117732710

PSWI:

130192280(ccnd1) 130194907

MSAM:

119890260(ccnd1) 119894289

SCHU:

122875207 122876462(ccnd1)

CUD:	121512170(ccnd1) 121514619

ALAT:

119017665(ccnd1) 119025008

MZE:	101467298 101485361(ccnd1)

ONL:	100691051(ccnd1) 100691373

OAU:	116331023 116332748(ccnd1)

OLA:	101169672(ccnd1)

OML:	112141930(ccnd1)

CSAI:

133457669(ccnd1)

XMA:	102233074(ccnd1)

XCO:	114143123(ccnd1)

XHE:	116719094(ccnd1)

PRET:

103462287(ccnd1)

PFOR:

103150949(ccnd1)

PLAI:

106941969(ccnd1)

PMEI:

106911618(ccnd1)

GAF:	122819633(ccnd1)

PPRL:

129353217(ccnd1)

CVG:	107096221(ccnd1)

CTUL:

119795187(ccnd1)

GMU:	124867399(ccnd1)

NFU:	107374449(ccnd1)

KMR:	108237918(ccnd1)

ALIM:

106510985(ccnd1)

NWH:	119423918(ccnd1)

AOCE:

111576239(ccnd1)

MCEP:

125005752(ccnd1) 125014367

CSEM:

103379080 103379853(ccnd1)

POV:	109625110(ccnd1) 109642994

SSEN:

122776245(ccnd1) 122776506

HHIP:

117759437(ccnd1) 117762757

HSP:	118110121 118113286(ccnd1)

PPLT:

128449886(ccnd1)

SMAU:

118302431(ccnd1) 118314882

LCF:	108877824 108879779 108884596

SDU:	111221119(ccnd1) 111234824

SLAL:

111647809 111669291(ccnd1) 111670038

XGL:	120792411(ccnd1) 120793380(zgc:158868)

BPEC:

110169262(ccnd1) 110174870

MALB:

109967859(ccnd1)

BSPL:

114852499(ccnd1)

SJO:	128358362(ccnd1) 128359220

SASA:

100306852(ccnd1) 106561617 106562055 106587137

STRU:

115152358 115167492 115197603 115202965

OTW:	112218887 112249039 112252678 112263573

OMY:	110499952 110506401 110524590 110526228(ccnd1)

OGO:	124004130 124033208 124033899 124035824

ONE:	115109686 115112096 115113563

OKI:	109867514 109885836 109889644 109895467

OKE:	118358618 118393712(ccnd1) 118398791 118400945

SALP:

111952420 111969292 111974408 112070040

SNH:	120025309 120045999 120054165 120066776

CCLU:

121531644 121557697 121573328 121577046

ELS:	105017289(ccnd1) 105018279

SFM:	108940463 108941209(ccnd1)

PKI:

111851863

AANG:

118215511 118228076

LOC:	102687804(ccnd1)

PSPA:

121295125 121305898(ccndx) 121329999

ARUT:

117432035(ccnd1) 117435119

PSEX:

120525945(ccnd1) 120542830

LCM:	102361167(CCND1) 102367471

CMK:	121850328(ccnd1)

RTP:	109919627(ccnd1) 109925537

CPLA:

122541966 122557612(ccnd1)

HOC:	132824516(ccnd1) 132831194

LERI:

129705590(ccnd1)

PMRN:

116952278

LRJ:

133347528

SPU:	115927903 373245

LPIC:

TCA:

HAME:

EAF:

FCY:	FRACYDRAFT_140762(dsCyc9b)

» show all

Reference

PMID:1826542

Authors

Motokura T, Bloom T, Kim HG, Juppner H, Ruderman JV, Kronenberg HM, Arnold A

Title

A novel cyclin encoded by a bcl1-linked candidate oncogene.

Journal

Nature 350:512-5 (1991)
DOI:10.1038/350512a0

Sequence

[hsa:595]

LinkDB

DBGET integrated database retrieval system