KEGG ORTHOLOGY: K08784

ORTHOLOGY: K08784

Entry

K08784                      KO

Symbol

HTRA1, PRSS11

Name

HtrA serine peptidase 1 [EC:3.4.21.-]

Disease

H00821

Age-related macular degeneration

H01757

Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K08784  HTRA1, PRSS11; HtrA serine peptidase 1
  09182 Protein families: genetic information processing
   03110 Chaperones and folding catalysts
    K08784  HTRA1, PRSS11; HtrA serine peptidase 1
Peptidases and inhibitors [BR:ko01002]
Serine peptidases
  Family S1: chymotrypsin family
   K08784  HTRA1, PRSS11; HtrA serine peptidase 1
Chaperones and folding catalysts [BR:ko03110]
Other chaperones and cochaperones
  DegP / HtrA
   K08784  HTRA1, PRSS11; HtrA serine peptidase 1

Genes

HSA:	5654(HTRA1)

PTR:	450792(HTRA1)

PPS:	100984844(HTRA1)

GGO:	101127178(HTRA1)

PON:	100437050(HTRA1)

PPYG:

129006513(HTRA1)

NLE:	100583976(HTRA1)

HMH:	116482512(HTRA1)

SSYN:

129465015(HTRA1)

MCC:	705855(HTRA1)

MCF:	102126844(HTRA1)

MTHB:

126962012

MNI:	105469893(HTRA1)

CSAB:

103216638(HTRA1)

CATY:

105577992(HTRA1)

PANU:

101013113(HTRA1)

TGE:	112631402(HTRA1)

MLEU:

105554593(HTRA1)

RRO:	104658066(HTRA1)

RBB:	108529745(HTRA1)

TFN:	117065497(HTRA1)

PTEH:

111550786(HTRA1)

CJC:	100398769(HTRA1)

SBQ:	101030381(HTRA1)

CIMI:

108282124(HTRA1)

ANAN:

105718002(HTRA1)

CSYR:

103254995(HTRA1)

MMUR:

105880301(HTRA1)

LCAT:

123649976(HTRA1)

PCOQ:

105808704(HTRA1)

OGA:	100950082(HTRA1)

MMU:	56213(Htra1)

MCAL:

110298288(Htra1)

MPAH:

110322568(Htra1)

RNO:	65164(Htra1)

MCOC:

116103091(Htra1)

ANU:	117710601(Htra1)

MUN:	110558355(Htra1)

CGE:	100762962(Htra1)

MAUA:

101837644(Htra1)

PROB:

127228441(Htra1)

PLEU:

114692557(Htra1)

MORG:

121458011(Htra1)

MFOT:

126515961

AAMP:

119818622(Htra1)

NGI:	103729266(Htra1)

HGL:	101703079(Htra1)

CPOC:

100716225(Htra1)

CCAN:

109691638(Htra1)

DORD:

105989723(Htra1)

DSP:	122126863(Htra1)

PLOP:

125345977(Htra1)

NCAR:

124985288

MMMA:

107152905(Htra1)

OCU:

100008705

OPI:	101521688(HTRA1)

TUP:	102497616(HTRA1)

GVR:	103589209(HTRA1)

CFA:	477852(HTRA1)

CLUD:

112672441(HTRA1)

VVP:	112916926(HTRA1)

VLG:	121485364(HTRA1)

NPO:	129493531(HTRA1)

AML:	100468862(HTRA1)

UMR:	103659391(HTRA1)

UAH:	113252019(HTRA1)

UAR:	123796032(HTRA1)

ELK:

111144826

LLV:

125084824

MPUF:

101682964(HTRA1)

MNP:	132016843(HTRA1)

MLK:	131830596(HTRA1)

NVS:	122901180(HTRA1)

ORO:	101377025(HTRA1)

EJU:	114223048(HTRA1)

ZCA:	113923555(HTRA1)

MLX:	118027345(HTRA1)

NSU:	110592735(HTRA1)

LWW:	102733875(HTRA1)

FCA:	101095920(HTRA1)

PYU:	121037483(HTRA1)

PCOO:

112854762(HTRA1)

PBG:	122493331(HTRA1)

PVIV:

125147829(HTRA1)

LRUF:

124506759

PTG:	102949412(HTRA1)

PPAD:

109273008(HTRA1)

PUC:

125933169

AJU:

106969384

HHV:	120244110(HTRA1)

BTA:	282326(HTRA1)

BOM:	102269881(HTRA1)

BIU:	109553084(HTRA1)

BBUB:

102396828(HTRA1)

BBIS:

105002762(HTRA1)

CHX:	102174540(HTRA1)

OAS:	101101854(HTRA1)

BTAX:

128067751(HTRA1)

ODA:	120873883(HTRA1)

CCAD:

122445854(HTRA1)

MBEZ:

129555284(HTRA1)

SSC:	100515628(HTRA1)

CFR:	102510440(HTRA1)

CBAI:

105080798(HTRA1)

CDK:	105104228(HTRA1)

VPC:	102532979(HTRA1)

BACU:

103007240(HTRA1)

BMUS:

118882640(HTRA1)

LVE:	103087438(HTRA1)

OOR:	101269446(HTRA1)

DLE:	111172233(HTRA1)

PCAD:

114485368

PSIU:

116741238(HTRA1)

NASI:

112406912(HTRA1)

ECB:	100064570(HTRA1)

EPZ:	103542384(HTRA1)

EAI:	106824430(HTRA1)

MYD:	102764423(HTRA1)

MMYO:

118655626(HTRA1)

MDT:	132214484(HTRA1)

PKL:	118710521(HTRA1)

EFUS:

103302469(HTRA1)

MNA:	107532666(HTRA1)

DRO:	112300265(HTRA1)

SHON:

118996285(HTRA1)

AJM:	119063505(HTRA1)

PDIC:

114496626(HTRA1)

PHAS:

123829086(HTRA1)

MMF:	118632266(HTRA1)

PPAM:

129077229(HTRA1)

HAI:	109382985(HTRA1)

RFQ:	117036158(HTRA1)

PALE:

102883658(HTRA1)

PGIG:

120608850(HTRA1)

PVP:	105306710(HTRA1)

RAY:	107512984(HTRA1)

MJV:	108396897(HTRA1)

TOD:	119233416(HTRA1)

SETR:

126033474(HTRA1)

LAV:	100675235(HTRA1)

TMU:

101352358

ETF:	101644660(HTRA1)

DNM:

101413665

MDO:	100025560(HTRA1)

GAS:	123238201(HTRA1)

SHR:	100930647(HTRA1)

AFZ:

127551660

PCW:	110202867(HTRA1)

TVP:	118830288(HTRA1)

OAA:	100093346(HTRA1)

GGA:	100857572(HTRA1)

PCOC:

116231559(HTRA1)

MGP:	100541363(HTRA1)

CJO:	107316299(HTRA1)

TPAI:

128077639(HTRA1)

LMUT:

125693331(HTRA1)

NMEL:

110400047(HTRA1)

APLA:

101793219(HTRA1)

ACYG:

106038992(HTRA1)

CATA:

118248688(HTRA1)

AFUL:

116491228(HTRA1)

TGU:	100219623(HTRA1)

LSR:	110468435(HTRA1)

SCAN:

103814108(HTRA1)

PMOA:

120502057(HTRA1)

OTC:	121341644(HTRA1)

PRUF:

121350097(HTRA1)

GFR:	102043139(HTRA1)

FAB:	101813424(HTRA1)

OMA:	130254857(HTRA1)

PHI:	102106039(HTRA1)

PMAJ:

107206893(HTRA1)

CCAE:

111931380(HTRA1)

CCW:	104694592(HTRA1)

CBRC:

103624011(HTRA1)

ETL:	114069420(HTRA1)

ZAB:	102068034(HTRA1)

ZLE:	135449880(HTRA1)

ACHL:

103807336(HTRA1)

SVG:	106859482(HTRA1)

MMEA:

130582449(HTRA1)

HRT:	120756132(HTRA1)

SATI:

136363970(HTRA1)

FCH:	102058838(HTRA1)

CCRI:

104160087(HTRA1)

NNT:	104404921(HTRA1)

SHAB:

115608632(HTRA1)

ACUN:

113481713(HTRA1)

TALA:

104365088(HTRA1)

ACHC:

115348215(HTRA1)

HALD:

104320346(HTRA1)

HLE:	104830192(HTRA1)

AGEN:

126042951

GCL:

127017772

CSTI:

104557051(HTRA1)

LDI:

104351794

MNB:	103778871(HTRA1)

DPUB:

104309147(HTRA1)

AVIT:

104268331(HTRA1)

BRHI:

104488866(HTRA1)

EGZ:	104123677(HTRA1)

NNI:	104020575(HTRA1)

PADL:

103918648(HTRA1)

AFOR:

103897929(HTRA1)

FGA:	104078087(HTRA1)

GSTE:

104256227(HTRA1)

CLV:	102096252(HTRA1)

MUI:	104534747(HTRA1)

PGUU:

104467726(HTRA1)

PLET:

104628777

EHS:	104513614(HTRA1)

CMAC:

104478254(HTRA1)

CUCA:

104058558(HTRA1)

TEO:	104372623(HTRA1)

BREG:

104643068(HTRA1)

OHA:	104332347(HTRA1)

CPEA:

104394411(HTRA1)

CVF:

104283487

RTD:	128911542(HTRA1)

AAM:	106499018(HTRA1)

AROW:

112965212(HTRA1)

NPD:	112957050(HTRA1)

DNE:	112992091(HTRA1)

SCAM:

104145780(HTRA1)

ASN:	102385435(HTRA1)

AMJ:	102568843(HTRA1)

CPOO:

109323796(HTRA1)

GGN:	109287207(HTRA1)

PSS:	102448440(HTRA1)

CMY:	102941421(HTRA1)

CCAY:

125626268(HTRA4) 125640436(HTRA1)

DCC:	119848560(HTRA4) 119859503(HTRA1)

CPIC:

101942959(HTRA1)

TST:	117873029(HTRA4) 117880648(HTRA1)

CABI:

116821408(HTRA4) 116822667(HTRA1)

MRV:	120369207(HTRA1) 120398860(HTRA4)

ACS:	100559415(htra4) 100564246(htra1)

ASAO:

132771020(HTRA1) 132782750(HTRA4)

PVT:	110072161(HTRA4) 110075336(HTRA1)

SUND:

121925105(HTRA1) 121932484(HTRA4)

PBI:	103055911 103064390(HTRA1)

PMUR:

107288605(HTRA1)

CTIG:

120305740(HTRA1) 120312911(HTRA4)

TSR:

106538760

PGUT:

117676693(HTRA1) 117676950(HTRA4)

APRI:

131200657(HTRA1) 131203826(HTRA4)

PTEX:

113439162(HTRA1) 113445628 113445682

NSS:	113413242(HTRA1) 113420984(HTRA4)

VKO:	123024156(HTRA1) 123027031(HTRA4)

PMUA:

114597418(HTRA1)

PRAF:

128403163(HTRA4) 128414163(HTRA1)

ZVI:	118096652(HTRA1)

HCG:	128333578(HTRA4) 128352153(HTRA1)

GJA:	107122324(HTRA1)

STOW:

125425355(HTRA4) 125438257(HTRA1)

EMC:	129332824(HTRA1) 129341873(HTRA4)

XLA:	108696094(htra1.L) 108711647(htra4.L) 496061(htra1.S)

XTR:	100488607(htra4) 780187(htra1)

NPR:	108793047 108795417

RTEM:

120933183(HTRA4) 120947022(HTRA1)

BBUF:

120986269(HTRA4) 121005354(HTRA1)

BGAR:

122929424(HTRA4) 122941389(HTRA1)

MUO:	115469359(HTRA4) 115471035(HTRA1)

GSH:	117359470(HTRA1) 117362456(HTRA4)

DRE:	100334257(htra4) 431766(htra1a) 565082(htra1b)

SRX:	107716482 107717120 107744310 107745581 107750178

SANH:

107660481 107663307 107672779 107678347(htra1) 107689831

SGH:	107553988 107571737 107583526 107592346(htra4) 107598034

CCAR:

109080112

CAUA:

113049426 113072480 113091327 113111875 113113707 113117157

CGIB:

127958472 127968890 127975873 128009966 128024926 128031479

PTET:

122345947(htra4) 122355621 122355747 122361530(htra1a)

LROH:

127165634(htra4) 127174160(htra1b) 127180212(htra1a)

OMC:	131523152(htra1a) 131541360(htra4) 131551425(htra1b)

PPRM:

120470006(htra4) 120477915(htra1a) 120492944(htra1b)

RKG:	130070202(htra1b) 130070636(htra1a)

MAMB:

125255408(htra1b) 125266502(htra4) 125268780(htra1a)

CIDE:

127498072 127512782 127524024

CERY:

137006476(htra1a) 137007451(htra1b) 137034054(htra4)

MASI:

127411530 127423475 127427118 127428967 127455453

TROS:

130550772(htra4) 130560722(htra1a) 130569647(htra1b)

TDW:	130420022(htra4) 130437425(htra1a) 130438925(htra1b)

MANU:

129417044(htra1a) 129420616(htra1b) 129440093(htra4)

IPU:	108255963 108270147 108273788(htra1b)

IFU:	128599028(htra4) 128617526(htra1b)

PHYP:

113535060(htra1) 113542477 113547710

SMEO:

124380686(htra4) 124388579(htra1b) 124390442

TFD:	113638384(htra4) 113641410 113662531(htra1b)

TVC:	132840549(htra1b) 132852842 132854296(htra4)

TRN:	134321457(htra1b) 134324875 134335143(htra4)

AMEXあめっくす:

103028201(htra4) 103041103(htra1b) 103042183(htra1a)

CMAO:

118809668(htra1b) 118823829(htra1a) 118827781(htra4)

EEE:	113568073 113582709(htra1) 113588124

CHAR:

105889872(htra4) 105893453(htra1a) 105901293(htra1b)

TRU:	101062667 101076407

TFS:	130528922(htra1b) 130534147

TNG:	GSTEN00022346G001 GSTEN00031557G001

LCO:	104926079 104928139(htra1) 104931072

NCC:	104944757 104946544(htra1)

TBEN:

117473480(htra1b) 117499951(htra1a)

CGOB:

115013435 115019778 115024747

PGEO:

117459506(htra1a) 117465160

GACU:

117553547(htra1b) 117560735(htra1a)

EMAC:

134858374 134871140(htra1b)

ELY:	117246654(htra1b) 117248026 117253020

EFO:	125880661(htra1b) 125890962(htra4) 125903805

PLEP:

121944629(htra4) 121954571(htra1a) 121958845

SLUC:

116056152 116061594(htra1b)

ECRA:

117936686(htra1b) 117960828

ESP:	116671014(htra1) 116705100

PFLV:

114547975 114572130

GAT:	120819648(htra1b) 120820762 120830619(htra4)

PPUG:

119213296 119213923 119225097(htra4)

AFB:	129091091(htra1b) 129092278 129101879

CLUM:

117736205(htra4) 117744412 117748363

PSWI:

130196154(htra4) 130207289(htra1a)

MSAM:

119915616 119916143 119917623

SCHU:

122868002(htra1b) 122876319(htra4) 122884753

CUD:	121509788(htra4) 121510726 121528344(htra1b)

ALAT:

119010356(htra1b) 119020313(htra4) 119033653

MZE:	101471423(htra1) 101471622 101484981

ONL:	100694730 100711526 100711666(htra1)

OAU:	116321885 116324716(htra1b) 116325745

OLA:	101160199(htra1) 105355810

OML:	112154166(htra1b) 112162302

CSAI:

133418939(htra1b) 133451235(htra4) 133463649

XMA:	102218195 102219577(htra1)

XCO:	114137439 114151684(htra1)

XHE:	116712697 116727218(htra1)

PRET:

103476703 103481869(htra1)

PFOR:

103133639 103141952 103147052(htra1)

PLAI:

106937731 106945579 106957629

PMEI:

106908693 106919258(htra1) 106921519

GAF:	122823645(htra1b) 122842105

PPRL:

129360185(htra1a) 129367860(htra1b)

CVG:	107091711 107094975(htra1)

CTUL:

119776148(htra1b) 119790542(htra1a)

GMU:	124859645 124875680(htra1b)

NFU:	107375930 107387249(htra1)

KMR:	108242837(htra1a) 108250248(htra1b)

ALIM:

106528240(htra1) 106537336

NWH:	119424222(htra1b) 119430071

AOCE:

111569397(htra1) 111570651 111571498 111585196

MCEP:

125012302(htra4) 125019298 125022301(htra1b)

CSEM:

103382293 103387077(htra1)

POV:	109630016(htra1) 109633662 109644013

SSEN:

122759248 122769144(htra4) 122782319

HHIP:

117752650(htra1b) 117767843(htra4) 117775237(htra1a)

HSP:	118100562(htra1b) 118115170(htra4) 118119208(htra1a)

PPLT:

128437944(htra4) 128453149(htra1a)

SMAU:

118283659 118287194(htra1b) 118314142(htra4)

LCF:	108874736 108877995(htra4) 108897393

SDU:	111219863 111227457 111235188

SLAL:

111647973(htra4) 111663743 111664379

XGL:	120794675 120796501 120804703

HCQ:	109510102 109518597

SSCV:

125979003 125991373

SBIA:

133495385 133509356

PEE:	133410040 133418063

PTAO:

133468939 133485359

BPEC:

110157145 110165842

MALB:

109959707 109959781 109962804(htra1)

BSPL:

114842107 114845473(htra1b)

SJO:	128364983(htra4) 128372716 128381445

SASA:

100196695(htra1) 106577049 106578991 106585134 106607527

STRU:

115153255 115157554(htra1) 115164262 115193700 115201126

OTW:	112223485 112224241(htra1b) 112248684(htra4) 112253081 112254855

OMY:	110491421(htra1b) 110499019 110502507 110525899(htra4) 110529506

OGO:	124034137(htra4) 124038278 124040004 124041220 124048192

ONE:	115106393(htra1) 115111805 115113195 115135062 115144021

OKI:	109865738 109870394 109882447 109889980 109899116

OKE:	118357510 118367936(htra1b) 118369762 118393424(htra4) 118399940

SALP:

111951594 111974986 111978652(htra1) 111978739

SNH:	120017940 120029895 120045445 120045642 120051501(htra4)

CCLU:

121536797(htra1b) 121547296 121553648 121571283 121585052(htra4)

ELS:	105006447(htra1) 105010563 105014508(htra4)

SFM:	108932767 108939508(htra1) 108940300(htra4)

PKI:	111853712(htra1) 111857565 111858922

AANG:

118217750 118221524 118237424(htra4)

LOC:	102692747(htra1) 102692929(htra4)

PSPA:

121303222(htra4) 121321980 121325568(htra1b)

ARUT:

117397750 117415549 117417725(htra1b) 117971676

PSEX:

120539304(htra4) 120539348

LCM:	102345424(HTRA1) 102361645(HTRA4)

CMK:	103171855(htra4) 103185432(htra1b)

RTP:	109930711 109931827(htra1b)

CPLA:

122543127

HOC:	132826275(htra1b) 132836973

LERI:

129704003(htra1b) 129713213

PMRN:

LRJ:

CIN:

DFR:

TAES:

Reference

PMID:14973287

Authors

Oka C, Tsujimoto R, Kajikawa M, Koshiba-Takeuchi K, Ina J, Yano M, Tsuchiya A, Ueta Y, Soma A, Kanda H, Matsumoto M, Kawaichi M

Title

HtrA1 serine protease inhibits signaling mediated by Tgfbeta family proteins.

Journal

Development 131:1041-53 (2004)
DOI:10.1242/dev.00999

Sequence

[mmu:56213]

Reference

PMID:20671064

Authors

Campioni M, Severino A, Manente L, Tuduce IL, Toldo S, Caraglia M, Crispi S, Ehrmann M, He X, Maguire J, De Falco M, De Luca A, Shridhar V, Baldi A

Title

The serine protease HtrA1 specifically interacts and degrades the tuberous sclerosis complex 2 protein.

Journal

Mol Cancer Res 8:1248-60 (2010)
DOI:10.1158/1541-7786.MCR-09-0473

LinkDB

DBGET integrated database retrieval system