KEGG ORTHOLOGY: K13240

ORTHOLOGY: K13240

Entry

K13240                      KO

Symbol

NOS1

Name

nitric-oxide synthase, brain [EC:1.14.13.39]

Pathway

map00220

Arginine biosynthesis

map00330

Arginine and proline metabolism

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

map04020

Calcium signaling pathway

map04145

Phagosome

map04371

Apelin signaling pathway

map04713

Circadian entrainment

map04730

Long-term depression

map04926

Relaxin signaling pathway

map04970

Salivary secretion

map05010

Alzheimer disease

map05014

Amyotrophic lateral sclerosis

map05022

Pathways of neurodegeneration - multiple diseases

map05410

Hypertrophic cardiomyopathy

map05412

Arrhythmogenic right ventricular cardiomyopathy

map05414

Dilated cardiomyopathy

map05416

Viral myocarditis

Reaction

R00111

N-(omega)-hydroxyarginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming)

R00557

L-arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming)

R00558

L-arginine,NADPH:oxygen oxidoreductase (N-(omega)-hydroxyarginine-forming)

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00220 Arginine biosynthesis
    K13240  NOS1; nitric-oxide synthase, brain
   00330 Arginine and proline metabolism
    K13240  NOS1; nitric-oxide synthase, brain
09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    K13240  NOS1; nitric-oxide synthase, brain
   04020 Calcium signaling pathway
    K13240  NOS1; nitric-oxide synthase, brain
09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    K13240  NOS1; nitric-oxide synthase, brain
09150 Organismal Systems
  09152 Endocrine system
   04926 Relaxin signaling pathway
    K13240  NOS1; nitric-oxide synthase, brain
  09154 Digestive system
   04970 Salivary secretion
    K13240  NOS1; nitric-oxide synthase, brain
  09156 Nervous system
   04730 Long-term depression
    K13240  NOS1; nitric-oxide synthase, brain
  09159 Environmental adaptation
   04713 Circadian entrainment
    K13240  NOS1; nitric-oxide synthase, brain
09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K13240  NOS1; nitric-oxide synthase, brain
   05014 Amyotrophic lateral sclerosis
    K13240  NOS1; nitric-oxide synthase, brain
   05022 Pathways of neurodegeneration - multiple diseases
    K13240  NOS1; nitric-oxide synthase, brain
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    K13240  NOS1; nitric-oxide synthase, brain
   05412 Arrhythmogenic right ventricular cardiomyopathy
    K13240  NOS1; nitric-oxide synthase, brain
   05414 Dilated cardiomyopathy
    K13240  NOS1; nitric-oxide synthase, brain
   05416 Viral myocarditis
    K13240  NOS1; nitric-oxide synthase, brain
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.39  nitric-oxide synthase (NADPH)
     K13240  NOS1; nitric-oxide synthase, brain

Other DBs

GO:

0004517

Genes

HSA:	4842(NOS1)

PTR:	467139(NOS1)

PPS:	100996089(NOS1)

GGO:	101147071(NOS1)

PON:	100433069(NOS1)

PPYG:

129010490(NOS1)

NLE:	100597250(NOS1)

HMH:	116477857(NOS1)

SSYN:

129459367(NOS1)

MCC:	693781(NOS1)

MCF:	102123521(NOS1)

MTHB:

126930595

MNI:	105495113(NOS1)

CATY:

105592744(NOS1)

PANU:

101025542(NOS1)

TGE:	112634545(NOS1)

MLEU:

105527995(NOS1)

RRO:	104675533(NOS1)

RBB:	108539288(NOS1)

TFN:	117089332(NOS1)

PTEH:

111537519(NOS1)

CANG:

105502297(NOS1)

CJC:	100895717(NOS1)

SBQ:	101034544(NOS1)

CIMI:

108305039(NOS1)

ANAN:

105728826(NOS1)

CSYR:

103250172

MMUR:

105866961(NOS1)

LCAT:

123626251(NOS1)

PCOQ:

105825189(NOS1)

OGA:	100946509(NOS1)

MMU:	18125(Nos1)

MCAL:

110294416(Nos1)

MPAH:

110312876(Nos1)

RNO:	24598(Nos1)

MCOC:

116068288(Nos1)

ANU:	117697935(Nos1)

MUN:	110551884(Nos1)

CGE:	100758127(Nos1)

MAUA:

101830457(Nos1)

PROB:

127216013(Nos1)

PLEU:

114699651(Nos1)

MORG:

121445990(Nos1)

MFOT:

126511745

AAMP:

119824418(Nos1)

NGI:	103745523(Nos1)

HGL:	101711993(Nos1)

CPOC:

100729682(Nos1)

CCAN:

109686387(Nos1)

DORD:

105984213(Nos1)

DSP:	122099033(Nos1)

PLOP:

125349073(Nos1)

NCAR:

124991150

MMMA:

107156451(Nos1)

OCU:	100009243(NOS1)

OPI:	101522087(NOS1)

TUP:	102480558(NOS1)

GVR:	103593457(NOS1)

CFA:	477498(NOS1)

CLUD:

112676630(NOS1)

VVP:	112932933(NOS1)

VLG:	121475796(NOS1)

NPO:	129508386(NOS1)

AML:	100468087(NOS1)

UMR:	103661304(NOS1)

UAH:	113266817(NOS1)

UAR:	123778556(NOS1)

ELK:

111156411

LLV:

125082424

MPUF:

101692439(NOS1)

MNP:	132023203(NOS1)

MLK:	131811917(NOS1)

NVS:	122903384(NOS1)

ORO:	101375441(NOS1)

EJU:	114219124(NOS1)

ZCA:	113913115(NOS1)

MLX:	118018518(NOS1)

NSU:	110588225(NOS1)

LWW:	102726309(NOS1)

FCA:	101100342(NOS1)

PYU:	121010269(NOS1)

PCOO:

112870473(NOS1)

PBG:	122470274(NOS1)

PVIV:

125149674(NOS1)

LRUF:

124518489

PTG:	102962715(NOS1)

PPAD:

109277571(NOS1)

PUC:

125914124

AJU:

106971710

HHV:	120232363(NOS1)

BTA:	536132(NOS1)

BOM:	102280537(NOS1)

BIU:	109571319(NOS1)

BBUB:

102400136(NOS1)

BBIS:

104980001(NOS1)

CHX:	102185490(NOS1)

OAS:	443533(NOS1)

BTAX:

128062518(NOS1)

ODA:	120871573(NOS1)

CCAD:

122423224(NOS1)

MBEZ:

129542907(NOS1)

SSC:	100520934(NOS1)

CFR:	102508946(NOS1)

CBAI:

105075702(NOS1)

CDK:	105104911(NOS1)

VPC:	102542069(NOS1)

BACU:

103008209(NOS1)

BMUS:

118880040(NOS1)

LVE:	103090138(NOS1)

OOR:	101273057(NOS1)

DLE:	111186931(NOS1)

PCAD:

102991967(NOS1)

PSIU:

116738822(NOS1)

NASI:

112408771(NOS1)

ECB:	100051079(NOS1)

EPZ:	103547950(NOS1)

EAI:	106839766(NOS1)

MYB:	102260489(NOS1)

MYD:	102763635(NOS1)

MMYO:

118678505(NOS1)

MLF:	102433074(NOS1)

MDT:	132222309(NOS1)

PKL:	118725282(NOS1)

EFUS:

103287084(NOS1)

MNA:	107528483(NOS1)

DRO:	112310614(NOS1)

SHON:

118991149(NOS1)

AJM:	119057483(NOS1)

PDIC:

114509381(NOS1)

PHAS:

123820989(NOS1)

MMF:	118639832(NOS1)

PPAM:

129087355(NOS1)

HAI:	109382238(NOS1)

RFQ:	117017522(NOS1)

PALE:

102884569(NOS1)

PGIG:

120606760(NOS1)

PVP:	105289401(NOS1)

RAY:	107513162(NOS1)

MJV:	108397443(NOS1)

TOD:	119244938(NOS1)

SARA:

101559239(NOS1)

SETR:

126030681(NOS1)

LAV:	100673992(NOS1)

TMU:

101342004

ETF:	101649945(NOS1)

DNM:	101411311(NOS1)

MDO:	100013712(NOS1)

GAS:	123256892(NOS1)

SHR:	100921140(NOS1)

AFZ:

127545521

PCW:	110222812(NOS1)

TVP:	118833681(NOS1)

OAA:	100093259(NOS1)

GGA:	427721(NOS1)

PCOC:

116228339(NOS1)

MGP:	100538441(NOS1)

CJO:	107321466(NOS1)

TPAI:

128084048(NOS1)

LMUT:

125701757(NOS1)

NMEL:

110406170(NOS1)

APLA:

101798766(NOS1)

ACYG:

106045554(NOS1)

CATA:

118252937(NOS1)

AFUL:

116496320(NOS1)

TGU:	100231414(NOS1) 116807264

LSR:	110474155(NOS1)

SCAN:

103818226(NOS1)

PMOA:

120510300(NOS1)

OTC:	121344475(NOS1)

PRUF:

121364923(NOS1)

GFR:	102042821(NOS1)

FAB:	101820761(NOS1)

OMA:	130259689(NOS1)

PHI:	102106809(NOS1)

PMAJ:

107211573(NOS1)

CCAE:

111936662(NOS1)

CCW:	104695038(NOS1)

CBRC:

103623761(NOS1)

ETL:	114071586(NOS1)

ZAB:	102072905(NOS1)

ZLE:	135454488(NOS1)

ACHL:

103801580(NOS1)

SVG:	106864783(NOS1)

MMEA:

130580139(NOS1)

HRT:	120760593(NOS1)

SATI:

136368734(NOS1)

FPG:	101916747(NOS1)

FCH:	102047821(NOS1)

CCRI:

104160807(NOS1)

NNT:	104404829(NOS1)

SHAB:

115614078(NOS1)

ACUN:

113486129(NOS1)

TALA:

104361402(NOS1)

ACHC:

115346336(NOS1)

HALD:

104317081

HLE:	104829234(NOS1)

AGEN:

126041320

GCL:

127022735

CSTI:

104560255(NOS1)

LDI:	104350797(NOS1)

MNB:	103780992(NOS1)

DPUB:

104308456(NOS1)

AVIT:

104270931(NOS1)

BRHI:

104498566(NOS1)

EGZ:	104129871(NOS1)

NNI:	104010553(NOS1)

PCRI:

104029088(NOS1)

PCAO:

104047115(NOS1)

PADL:

103913684(NOS1)

AFOR:

103894609(NOS1)

FGA:	104079195(NOS1)

GSTE:

104256505

CLV:	102093432(NOS1)

MUI:	104545975(NOS1)

PGUU:

104463690(NOS1)

EHS:	104503743(NOS1)

CMAC:

104476523(NOS1)

CUCA:

104056123(NOS1)

TEO:

104378429

BREG:

104640291(NOS1)

OHA:	104334673(NOS1)

ACAR:

104533031(NOS1)

CPEA:

104386992(NOS1)

CVF:	104288003(NOS1)

RTD:	128917230(NOS1)

AAM:	106493898(NOS1)

AROW:

112976786(NOS1)

NPD:	112950374(NOS1)

TGT:	104566767(NOS1)

DNE:	112994650(NOS1)

SCAM:

104144123(NOS1)

ASN:	102380334(NOS1)

AMJ:	102561243(NOS1)

CPOO:

109312966(NOS1)

GGN:	109290264(NOS1)

PSS:	102444149(NOS1)

CMY:	102941829(NOS1)

CCAY:

125622860(NOS1)

DCC:	119843783(NOS1)

CPIC:

101937660(NOS1)

TST:	117888179(NOS1)

CABI:

116836436(NOS1)

MRV:	120386165(NOS1)

ACS:	100562233(nos1)

ASAO:

132781320(NOS1)

PVT:	110090104(NOS1)

SUND:

121916538(NOS1)

PBI:	103052972(NOS1)

PMUR:

107295430(NOS1)

CTIG:

120303216(NOS1)

PGUT:

117657845(NOS1)

APRI:

131185597(NOS1)

PTEX:

113448063(NOS1)

NSS:	113423103(NOS1)

VKO:	123032750(NOS1)

PMUA:

114587067(NOS1)

PRAF:

128404348(NOS1)

ZVI:	118075983(NOS1)

HCG:	128337869(NOS1)

GJA:	107112296(NOS1)

STOW:

125442897(NOS1)

EMC:	129341149(NOS1)

XLA:	108707179(nos1.S) 373705(nos1.L)

XTR:	100497595(nos1)

NPR:	108785232(NOS1)

RTEM:

120932977(NOS1)

BBUF:

120991402(NOS1)

BGAR:

122935037(NOS1)

MUO:	115480833(NOS1)

GSH:	117365575(NOS1)

DRE:	60658(nos1)

SRX:	107726721 107755829(nos1)

SANH:

107668720 107704495(nos1)

SGH:	107599142(nos1) 107599638

CCAR:

109079125 109079156

CAUA:

113068104 113072250

CGIB:

127958782 128014048

PTET:

122345918(nos1)

LROH:

127165699(nos1)

OMC:	131540926(nos1)

PPRM:

120470411(nos1)

RKG:	130088116(nos1)

MAMB:

125267321(nos1)

CIDE:

127513479

CERY:

137033562(nos1)

MASI:

127430098 127437581

TROS:

130568910(nos1)

TDW:	130419971(nos1)

MANU:

129439681(nos1)

IPU:

108255344

IFU:	128625645(nos1)

PHYP:

113537215(nos1)

SMEO:

124380832(nos1)

TFD:	113653396(nos1)

TVC:	132855098(nos1)

TRN:	134335673(nos1)

AMEXあめっくす:

103046065(nos1)

CMAO:

118827487(nos1)

EEE:	113577767(nos1)

CHAR:

105901066(nos1)

TRU:	101066909(nos1)

TFS:	130525474(nos1)

TNG:	GSTEN00029052G001

LCO:	104923687(nos1)

NCC:	104967506(nos1)

TBEN:

117472383(nos1)

CGOB:

115014031(nos1)

PGEO:

117452369(nos1)

GACU:

117552032(nos1)

EMAC:

134874257(nos1)

ELY:	117252891(nos1)

EFO:	125890062(nos1)

PLEP:

121943974(nos1)

SLUC:

116054158(nos1)

ECRA:

117944931(nos1)

ESP:	116688962(nos1)

PFLV:

114555256(nos1)

GAT:	120830799(nos1)

PPUG:

119225179(nos1)

AFB:	129100941(nos1)

CLUM:

117736441(nos1)

PSWI:

130196089(nos1)

MSAM:

119892185(nos1)

SCHU:

122876330(nos1)

CUD:	121510247(nos1)

ALAT:

119019240(nos1)

MZE:	101485683(nos1)

ONL:	100534582(nos1)

OAU:	116325579(nos1)

OLA:	100049502(nos1)

OML:	112148312(nos1)

CSAI:

133450964(nos1)

XMA:	102233853(nos1)

XCO:	114154866(nos1)

XHE:	116729879(nos1)

PRET:

103469871(nos1)

PFOR:

103134950(nos1)

PLAI:

106945253(nos1)

PMEI:

106919449(nos1)

GAF:	122827934(nos1)

PPRL:

129365983(nos1)

CVG:	107087335(nos1)

CTUL:

119788886(nos1)

GMU:	124878013(nos1)

NFU:	107386248(nos1)

KMR:	108246938(nos1)

ALIM:

106519449(nos1)

NWH:	119413183(nos1)

AOCE:

111572539(nos1)

MCEP:

125012597(nos1)

CSEM:

103396877 103397851(nos1)

POV:	109637139(nos1)

SSEN:

122769681(nos1)

HHIP:

117768184(nos1)

HSP:	124852411(nos1)

PPLT:

128438297(nos1)

SMAU:

118314181(nos1)

LCF:

108903114

SDU:	111227324(nos1)

SLAL:

111663111(nos1)

XGL:	120805277(nos1)

HCQ:	109525272(nos1)

SSCV:

125994306

SBIA:

133498974(nos1)

PEE:	133399636(nos1)

PTAO:

133475650(nos1)

BPEC:

110155016(nos1)

MALB:

109959109(nos1)

BSPL:

114862412(nos1)

SJO:	128364109(nos1)

SASA:

100136388(nos1) 106585241

STRU:

115164132 115200502

OTW:	112248861(nos1) 112262564

OMY:	100136347(nos1) 110535113

OGO:	124034044(nos1) 124035286

ONE:	115111915(nos1)

OKI:	109883580 109896184

OKE:	118357968 118393530(nos1)

SALP:

111958203 111974596

SNH:	120043829(nos1) 120062808

CCLU:

121530778 121585214(nos1)

ELS:	105031277(nos1)

SFM:	108927312(nos1)

PKI:	111851114 111852748(nos1)

AANG:

118206631(nos1)

LOC:	102699252(nos1)

PSPA:

121296840 121299518

ARUT:

117394670 117394704 117426910 117428352

PSEX:

120540577(nos1)

LCM:	102348281(NOS1)

CMK:	103184386(nos1)

RTP:	109914181(nos1)

CPLA:

122557039 122562749(nos1)

HOC:	132820423 132827371(nos1)

LERI:

129709305(nos1)

PMRN:

116939115 116950297 116950298

LRJ:	133348491 133348734 133348736

BFO:	118404760 118413899 118426508

BBEL:

109469130 109475091 109479447

CIN:

100183039

SCLV:

120325991 120326000

SPU:	100888109 587111

LPIC:

129254933

APLC:

110976884 110976936

ARUN:

117290268 117291015

AJC:	117110033 117124583 117124609

DME:	Dmel_CG6713(Nos)

DER:

6542987

DSE:

6612066

DSI:	Dsimw501_GD22223(Dsim_GD22223)

DYA:	Dyak_GE13295

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI17812

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:	106620796 106621192

BDR:	105223466 105229149

RZE:	108355020 108373227 108374600

AOQ:	129247071 129248198

TDA:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ000366 CpipJ_CPIJ019871

CPII:

120432426

CNS:

116341093

BCOO:

119078115 119085893

AME:	503861(NOS)

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:	105675559(Nos)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:	100313941(Nos)

CSOL:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

100144542(NOS2) 692510(NOS1)

BMAN:

114243188 114243206

MSEX:

115445277 115445279

DPL:	KGM_202094

BANY:

112048436 112048444

MJU:	123878619 123879669

NIQ:	126769943 126769944

VCD:	124533560 124533780

MCIX:

123653672 123653673

PMAC:

106718432 106718546

PPOT:

106104091 106105182

PXU:	106128430 106128432

PRAP:

110995634 110995640

PBX:	123708272 123708858

PNAP:

125049457 125049759

ZCE:	119834982 119834983

CCRC:

123691099 123691247

LSIN:

126966145 126966156

AAGE:

121731485 121731486

HAW:	110378704 110378714

HZE:	124631003 124631184

TNL:	113504450 113504511 113504548

SLIU:

111351570 111351952

OFU:	114365595 114365602

ATRA:

106134483 106134527

GMW:	113517211 113517251

PXY:	105388815 105388816

PGW:	126367455 126367457

LGLY:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

106678228(Nos)

NLU:

111044297

HVI:	124367568 124367569

MQU:

128986362

PHU:	Phum_PHUM176630

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_314346 DAPPUDRAFT_49977

DMK:

116928975

DPZ:

124310869

PVM:	113823177 113828626

PJA:

PCHN:

PMOO:

HAME:

PCLA:

123754516 123754968 123755062 123759937

CQD:	128693791 128696545

PTRU:

123510911

ESN:	126998963 127006615

MNZ:	135208562 135208564 135208569 135225877

HAZT:

PPOI:

ISC:

DSV:

RSAN:

RMP:

TUT:

DPTE:

DFR:

CSCU:

CVS:	136986695(Nos) 136986728

PTEP:

ABRU:

UDV:

SDM:

PMEO:

LGI:	LOTGIDRAFT_197993

PVUL:

126823850

PCAN:

112563084

GAE:	121368198 121368682 121390711 121391199

HRF:	124112147 124116041 124116043 124150822

HRJ:	124254027 124254028 124275692 124278491

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

MCAF:

127711441 127711952 127736405

MMER:

RPHI:

DPOL:

MAEA:

LJP:	135476993 135477184

LAK:

LLON:

NVE:

EPA:

ATEN:

ADF:	107337967 107341488 107355966

AMIL:

114957458 114967140

PDAM:

113685754

SPIS:

111339078 111345090

DGT:	114523867 114524113

XEN:

124433818

HSY:	130613373 130628780 130629288

RES:

135683007

TAD:	TRIADDRAFT_18893 TRIADDRAFT_19964 TRIADDRAFT_31504

NPA:	UCRNP2_4118

» show all

Reference

PMID:7528745

Authors

Hall AV, Antoniou H, Wang Y, Cheung AH, Arbus AM, Olson SL, Lu WC, Kau CL, Marsden PA

Title

Structural organization of the human neuronal nitric oxide synthase gene (NOS1).

Journal

J Biol Chem 269:33082-90 (1994)

Sequence

[hsa:4842]

LinkDB

DBGET integrated database retrieval system