Entry |
|
Name |
Mutation-activated PI3K to PI3K signaling pathway
|
Definition |
PI3K* -> PIP3 -> AKT -> MTOR -> S6K |
Expanded |
5290v1 -> C05981 -> (207,208,10000) -> 2475 -> (6198,6199) |
Class |
|
Type |
Variant
|
Pathway |
|
Disease |
H00048 | Hepatocellular carcinoma |
|
Gene |
5290 | PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha |
207 | AKT1; AKT serine/threonine kinase 1 |
208 | AKT2; AKT serine/threonine kinase 2 |
10000 | AKT3; AKT serine/threonine kinase 3 |
2475 | MTOR; mechanistic target of rapamycin |
6198 | RPS6KB1; ribosomal protein S6 kinase B1 |
6199 | RPS6KB2; ribosomal protein S6 kinase B2 |
|
Variant |
5290v1 (PI3K*) PIK3CA mutation
|
Metabolite |
C05981 | Phosphatidylinositol-3,4,5-trisphosphate |
|
Reference |
|
Authors |
Ignatiadis M, Sotiriou C |
Title |
Luminal breast cancer: from biology to treatment. |
Journal |
|
Reference |
|
Authors |
Mukohara T |
Title |
PI3K mutations in breast cancer: prognostic and therapeutic implications. |
Journal |
|
Reference |
|
Authors |
Whittaker S, Marais R, Zhu AX |
Title |
The role of signaling pathways in the development and treatment of hepatocellular carcinoma. |
Journal |
|
LinkDB |
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