Entry |
|
Name |
TGFA-overexpression to PLCG-PKC signaling pathway
|
Definition |
TGFA* -> EGFR -> PLCG -> IP3 -> (Ca2+,DAG) -> PKC -> ELK1 |
Expanded |
7039v1 -> 1956 -> (5335,5336) -> C01245 -> (C00076,C00165) -> (5578,5579,5582) -> 2002 |
Class |
|
Type |
Variant
|
Pathway |
|
Disease |
H00048 | Hepatocellular carcinoma |
|
Gene |
7039 | TGFA; transforming growth factor alpha |
1956 | EGFR; epidermal growth factor receptor |
5335 | PLCG1; phospholipase C gamma 1 |
5336 | PLCG2; phospholipase C gamma 2 |
5578 | PRKCA; protein kinase C alpha |
5579 | PRKCB; protein kinase C beta |
5582 | PRKCG; protein kinase C gamma |
2002 | ELK1; ELK1, ETS transcription factor |
|
Variant |
7039v1 (TGFA*) TGFA overexpression
|
Metabolite |
C01245 | D-myo-Inositol 1,4,5-trisphosphate |
|
Reference |
|
Authors |
Breuhahn K, Longerich T, Schirmacher P |
Title |
Dysregulation of growth factor signaling in human hepatocellular carcinoma. |
Journal |
|
LinkDB |
|