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KEGG NETWORK: N00910
NETWORK: N00910
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Entry
N00910 Network
Name
GHRHR-PKA-GH signaling pathway
Definition
GHRH -> GHRHR -> GNAS -> ADCY -> cAMP -> PKA -> CREB => POU1F1 => (GH1,
GH2)
Expanded
2691 -> 2692 -> 2778 -> (107,
108,
109,
196883,
111,
112,
113,
114,
115) -> C00575 -> (5566+5567+5568) -> (10488,
1385,
1386,
1388,
148327,
468,
64764,
84699,
90993,
9586) => 5449 => (2688,
2689)
Class
nt06324
GHRH-GH-IGF signaling
Type
Reference
Pathway
hsa04935
Growth hormone synthesis, secretion and action
Gene
2691
GHRH; growth hormone releasing hormone
2692
GHRHR; growth hormone releasing hormone receptor
2778
GNAS; GNAS complex locus
107
ADCY1; adenylate cyclase 1
108
ADCY2; adenylate cyclase 2
109
ADCY3; adenylate cyclase 3
196883
ADCY4; adenylate cyclase 4
111
ADCY5; adenylate cyclase 5
112
ADCY6; adenylate cyclase 6
113
ADCY7; adenylate cyclase 7
114
ADCY8; adenylate cyclase 8
115
ADCY9; adenylate cyclase 9
5566
PRKACA; protein kinase cAMP-activated catalytic subunit alpha
5567
PRKACB; protein kinase cAMP-activated catalytic subunit beta
5568
PRKACG; protein kinase cAMP-activated catalytic subunit gamma
10488
CREB3; cAMP responsive element binding protein 3
1385
CREB1; cAMP responsive element binding protein 1
1386
ATF2; activating transcription factor 2
1388
ATF6B; activating transcription factor 6 beta
148327
CREB3L4; cAMP responsive element binding protein 3 like 4
468
ATF4; activating transcription factor 4
64764
CREB3L2; cAMP responsive element binding protein 3 like 2
84699
CREB3L3; cAMP responsive element binding protein 3 like 3
90993
CREB3L1; cAMP responsive element binding protein 3 like 1
9586
CREB5; cAMP responsive element binding protein 5
5449
POU1F1; POU class 1 homeobox 1
2688
GH1; growth hormone 1
2689
GH2; growth hormone 2
Metabolite
C00575
3',5'-Cyclic AMP
Reference
PMID:
9167959
Authors
Bertherat J
Title
Nuclear effects of the cAMP pathway activation in somatotrophs.
Journal
Horm Res 47:245-50 (1997)
DOI:
10.1159/000185471
Reference
PMID:
8625613
Authors
Tuggle CK, Trenkle A
Title
Control of growth hormone synthesis.
Journal
Domest Anim Endocrinol 13:1-33 (1996)
DOI:
10.1016/0739-7240(95)00059-3
Reference
PMID:
16628271
Authors
Lengyel AM
Title
From growth hormone-releasing peptides to ghrelin: discovery of new modulators of GH secretion.
Journal
Arq Bras Endocrinol Metabol 50:17-24 (2006)
DOI:
10.1590/s0004-27302006000100004
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