| Entry |
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| Name |
Escherichia Tir to TLR2/4-MAPK signaling pathway
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| Definition |
Tir -> SHP1/2 -| (TRAF6+TAK1+TAB2) |
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| Expanded |
K12784 -> (5777+5781) -| (7189+6885+23118) |
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| Class |
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| Type |
Pathogen
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| Pathway |
| hsa05130 | Pathogenic Escherichia coli infection |
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| Disease |
| H00277 | Enterohemorrhagic Escherichia coli (EHEC) infection |
| H00278 | Enteropathogenic Escherichia coli (EPEC) infection |
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| Gene |
| 5777 | PTPN6; protein tyrosine phosphatase non-receptor type 6 |
| 5781 | PTPN11; protein tyrosine phosphatase non-receptor type 11 |
| 7189 | TRAF6; TNF receptor associated factor 6 |
| 6885 | MAP3K7; mitogen-activated protein kinase kinase kinase 7 |
| 23118 | TAB2; TGF-beta activated kinase 1 (MAP3K7) binding protein 2 |
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|---|
| Perturbant |
| K12784 (Tir) | tir; translocated intimin receptor |
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| Reference |
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| Authors |
Yan D, Wang X, Luo L, Cao X, Ge B |
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| Title |
Inhibition of TLR signaling by a bacterial protein containing immunoreceptor tyrosine-based inhibitory motifs. |
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| Journal |
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| LinkDB |
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