NETWORK: N01353 Help
Entry Name E2 to RAS-ERK signaling pathway
Definition E2 -> ESR1/2 -> SRC -> RAS -> RAF -> MEK -> ERK -> (ESR1/2,AP1) => CHRNA9
Expanded C00951 -> (2099,2100) -> 6714 -> (3265,3845,4893) -> (369,673,5894) -> (5604,5605) -> (5594,5595) -> ((2099,2100),(2353,3725)) => 55584
Class Type Env factor
Pathway hsa05207 Chemical carcinogenesis - receptor activation
Disease Gene 2099 ESR1; estrogen receptor 1
2100 ESR2; estrogen receptor 2
6714 SRC; SRC proto-oncogene, non-receptor tyrosine kinase
3265 HRAS; HRas proto-oncogene, GTPase
3845 KRAS; KRAS proto-oncogene, GTPase
4893 NRAS; NRAS proto-oncogene, GTPase
369 ARAF; A-Raf proto-oncogene, serine/threonine kinase
673 BRAF; B-Raf proto-oncogene, serine/threonine kinase
5894 RAF1; Raf-1 proto-oncogene, serine/threonine kinase
5604 MAP2K1; mitogen-activated protein kinase kinase 1
5605 MAP2K2; mitogen-activated protein kinase kinase 2
5594 MAPK1; mitogen-activated protein kinase 1
5595 MAPK3; mitogen-activated protein kinase 3
2353 FOS; Fos proto-oncogene, AP-1 transcription factor subunit
3725 JUN; Jun proto-oncogene, AP-1 transcription factor subunit
55584 CHRNA9; cholinergic receptor nicotinic alpha 9 subunit
Perturbant Reference Authors Zhang MH, Man HT, Zhao XD, Dong N, Ma SL
Title Estrogen receptor-positive breast cancer molecular signatures and therapeutic potentials (Review).
Journal Reference Authors Wu CH, Lee CH, Ho YS
Title Nicotinic acetylcholine receptor-based blockade: applications of molecular targets for cancer therapy.
Journal Reference Authors Lee CH, Chang YC, Chen CS, Tu SH, Wang YJ, Chen LC, Chang YJ, Wei PL, Chang HW, Chang CH, Huang CS, Wu CH, Ho YS
Title Crosstalk between nicotine and estrogen-induced estrogen receptor activation induces alpha9-nicotinic acetylcholine receptor expression in human breast cancer cells.
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