| Entry |
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| Name |
P4-PR-RAS-ERK signaling pathway
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| Definition |
P4 -> (PGR+SRC) -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK -> CCND1 |
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| Expanded |
C00410 -> (5241+6714) -> 2885 -> (6654,6655) -> (3265,3845,4893) -> (369,673,5894) -> (5604,5605) -> (5594,5595) -> 595 |
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| Class |
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| Type |
Reference
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| Gene |
| 5241 | PGR; progesterone receptor |
| 6714 | SRC; SRC proto-oncogene, non-receptor tyrosine kinase |
| 2885 | GRB2; growth factor receptor bound protein 2 |
| 6654 | SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 |
| 6655 | SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 |
| 3265 | HRAS; HRas proto-oncogene, GTPase |
| 3845 | KRAS; KRAS proto-oncogene, GTPase |
| 4893 | NRAS; NRAS proto-oncogene, GTPase |
| 369 | ARAF; A-Raf proto-oncogene, serine/threonine kinase |
| 673 | BRAF; B-Raf proto-oncogene, serine/threonine kinase |
| 5894 | RAF1; Raf-1 proto-oncogene, serine/threonine kinase |
| 5604 | MAP2K1; mitogen-activated protein kinase kinase 1 |
| 5605 | MAP2K2; mitogen-activated protein kinase kinase 2 |
| 5594 | MAPK1; mitogen-activated protein kinase 1 |
| 5595 | MAPK3; mitogen-activated protein kinase 3 |
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| Metabolite |
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| Reference |
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| Authors |
Pedroza DA, Subramani R, Lakshmanaswamy R |
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| Title |
Classical and Non-Classical Progesterone Signaling in Breast Cancers. |
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| Journal |
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| Reference |
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| Authors |
Faivre EJ, Daniel AR, Hillard CJ, Lange CA |
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| Title |
Progesterone receptor rapid signaling mediates serine 345 phosphorylation and tethering to specificity protein 1 transcription factors. |
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| Journal |
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| Reference |
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| Authors |
Boonyaratanakornkit V, Hamilton N, Marquez-Garban DC, Pateetin P, McGowan EM, Pietras RJ |
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| Title |
Extranuclear signaling by sex steroid receptors and clinical implications in breast cancer. |
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| Journal |
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| Reference |
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| Authors |
Mani SK, Oyola MG |
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| Title |
Progesterone signaling mechanisms in brain and behavior. |
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| Journal |
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| LinkDB |
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