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Gtf2e1 general transcription factor II E, polypeptide 1 (alpha subunit) [Mus musculus (house mouse)] - Gene - NCBI
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    Gtf2e1 general transcription factor II E, polypeptide 1 (alpha subunit) [ Mus musculus (house mouse) ]

    Gene ID: 74197, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Gtf2e1provided by MGI
    Official Full Name
    general transcription factor II E, polypeptide 1 (alpha subunit)provided by MGI
    Primary source
    MGI:MGI:1921447
    See related
    Ensembl:ENSMUSG00000022828 AllianceGenome:MGI:1921447
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FE; 56kDa; TFIIE-A; 2610024P03Rik
    Summary
    Predicted to enable RNA polymerase II general transcription initiation factor activity. Predicted to be involved in transcription open complex formation at RNA polymerase II promoter. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of transcription factor TFIID complex; transcription factor TFIIE complex; and transcription preinitiation complex. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; nervous system; and sensory organ. Orthologous to human GTF2E1 (general transcription factor IIE subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 12.8), CNS E14 (RPKM 8.7) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gtf2e1 in Genome Data Viewer
    Location:
    16 B3; 16 26.38 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (37330158..37360151, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (37509796..37539789, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene syntaxin binding protein 5-like Neighboring gene LIM and senescent cell antigen like domains 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_40782 Neighboring gene predicted gene, 57640 Neighboring gene STARR-seq mESC enhancer starr_40783 Neighboring gene STARR-positive B cell enhancer ABC_E2461 Neighboring gene RAB, member RAS oncogene family-like 3 Neighboring gene predicted gene, 46559 Neighboring gene homogentisate 1, 2-dioxygenase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation. Alpern D, et al. Elife, 2014 Sep 10. PMID 25209997, Free PMC Article
    2. Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria. Kamileri I, et al. Proc Natl Acad Sci U S A, 2012 Feb 21. PMID 22323595, Free PMC Article
    3. Oct4 links multiple epigenetic pathways to the pluripotency network. Ding J, et al. Cell Res, 2012 Jan. PMID 22083510, Free PMC Article
    4. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article
    5. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA polymerase II general transcription initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription initiation at RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription open complex formation at RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription factor TFIID complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription factor TFIIE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    general transcription factor IIE subunit 1
    Names
    TFIIE-alpha
    general transcription factor II E, polypeptide 1 (alpha subunit, 56kDa)
    general transcription factor IIE 56 kDa subunit
    general transcription factor IIE, polypeptide 1 (alpha subunit, 56kDa)
    transcription initiation factor IIE subunit alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355727.1 → NP_001342656.1  general transcription factor IIE subunit 1

      Status: VALIDATED

      Source sequence(s)
      AC154762
      Consensus CDS
      CCDS28160.1
      UniProtKB/Swiss-Prot
      Q544T0, Q9D0D5
      UniProtKB/TrEMBL
      Q8BV40
      Conserved Domains (2) summary
      smart00531
      Location:28 → 175
      TFIIE; Transcription initiation factor IIE
      pfam11521
      Location:395 → 440
      TFIIE-A_C; C-terminal general transcription factor TFIIE alpha

    2. NM_028812.4 → NP_083088.1  general transcription factor IIE subunit 1

      See identical proteins and their annotated locations for NP_083088.1

      Status: VALIDATED

      Source sequence(s)
      AC154762
      Consensus CDS
      CCDS28160.1
      UniProtKB/Swiss-Prot
      Q544T0, Q9D0D5
      UniProtKB/TrEMBL
      Q8BV40
      Related
      ENSMUSP00000023525.9, ENSMUST00000023525.9
      Conserved Domains (2) summary
      smart00531
      Location:28 → 175
      TFIIE; Transcription initiation factor IIE
      pfam11521
      Location:395 → 440
      TFIIE-A_C; C-terminal general transcription factor TFIIE alpha

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      37330158..37360151 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D0D5.1 GenPept UniProtKB/Swiss-Prot:Q9D0D5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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