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Page 1

Aberrant CD8⁺T cells drive reproductive dysfunction in female mice with elevated IFN-γ levels.

Bafor EE, Erwin-Cohen RA, Martin T, Baker C, Kimmel AE, Duverger O, Fenimore JM, Ramba M, Spindel T, Hess MM, Sanford M, Lazarevic V, Benayoun BA, Young HA, Valencia JC. Bafor EE, et al. Front Immunol. 2024 Apr 18;15:1368572. doi: 10.3389/fimmu.2024.1368572. eCollection 2024. Front Immunol. 2024. PMID: 38698852 Free PMC article.

Interferon-gamma contributes to disease progression in the Ndufs4(-/-) model of Leigh syndrome.

Hanaford AR, Khanna A, James K, Truong V, Liao R, Chen Y, Mulholland M, Kayser EB, Watanabe K, Hsieh ES, Sedensky M, Morgan PG, Kalia V, Sarkar S, Johnson SC. Hanaford AR, et al. Neuropathol Appl Neurobiol. 2024 Jun;50(3):e12977. doi: 10.1111/nan.12977. Neuropathol Appl Neurobiol. 2024. PMID: 38680020

Ablation of IFNγ in myeloid cells suppresses liver inflammation and fibrogenesis in mice with hepatic small heterodimer partner (SHP) deletion.

Zhu L, Litts B, Wang Y, Rein JA, Atzrodt CL, Chinnarasu S, An J, Thorson AS, Xu Y, Stafford JM. Zhu L, et al. Mol Metab. 2024 May;83:101932. doi: 10.1016/j.molmet.2024.101932. Epub 2024 Apr 6. Mol Metab. 2024. PMID: 38589002 Free PMC article.

Interferon-gamma signaling promotes cartilage regeneration after injury.

Kim JR, Hong BK, Pham THN, Kim WU, Kim HA. Kim JR, et al. Sci Rep. 2024 Apr 5;14(1):8046. doi: 10.1038/s41598-024-58779-0. Sci Rep. 2024. PMID: 38580748 Free PMC article.

IFNγ drives neuroinflammation, demyelination, and neurodegeneration in a mouse model of multiple system atrophy.

Corbin-Stein NJ, Childers GM, Webster JM, Zane A, Yang YT, Mudium N, Gupta R, Manfredsson FP, Kordower JH, Harms AS. Corbin-Stein NJ, et al. Acta Neuropathol Commun. 2024 Jan 18;12(1):11. doi: 10.1186/s40478-023-01710-x. Acta Neuropathol Commun. 2024. PMID: 38238869 Free PMC article.

Combining local cryoablation with PD-L1 blockade synergistically eradicates established murine lung cancer by modulating mitochondrial in PD-1+CD8+ T cell.

Zhai JW, Lv LL, Wu JJ, Zhang YX, Shen Y, Qu QX, Chen C. Zhai JW, et al. Immunol Lett. 2023 Nov;263:61-69. doi: 10.1016/j.imlet.2023.10.002. Epub 2023 Oct 5. Immunol Lett. 2023. PMID: 37805094

IFN-γ promotes PANoptosis in Pasteurella multocida toxin-induced pneumonia in mice.

Xiao H, Zhao Q, Yuan J, Liang W, Wu R, Wen Y, Du S, Wang Y, Zhao S, Lang Y, Yan Q, Huang X, Cao S. Xiao H, et al. Vet Microbiol. 2023 Oct;285:109848. doi: 10.1016/j.vetmic.2023.109848. Epub 2023 Sep 7. Vet Microbiol. 2023. PMID: 37722207

CD8⁺ T cells reduce neuroretina inflammation in mouse by regulating autoreactive Th1 and Th17 cells through IFN-γ.

Wu S, Zhang X, Hu C, Zhong Y, Chen J, Chong WP. Wu S, et al. Eur J Immunol. 2023 Dec;53(12):e2350574. doi: 10.1002/eji.202350574. Epub 2023 Sep 17. Eur J Immunol. 2023. PMID: 37689974

Microbiota-produced indole metabolites disrupt mitochondrial function and inhibit Cryptosporidium parvum growth.

Funkhouser-Jones LJ, Xu R, Wilke G, Fu Y, Schriefer LA, Makimaa H, Rodgers R, Kennedy EA, VanDussen KL, Stappenbeck TS, Baldridge MT, Sibley LD. Funkhouser-Jones LJ, et al. Cell Rep. 2023 Jul 25;42(7):112680. doi: 10.1016/j.celrep.2023.112680. Epub 2023 Jun 28. Cell Rep. 2023. PMID: 37384526 Free PMC article.

IFN-γ and androgens disrupt mitochondrial function in murine myocytes.

Fenimore JM, Springer DA, Romero ME, Edmondson EF, McVicar DW, Yanpallewar S, Sanford M, Spindel T, Engle E, Meyer TJ, Valencia JC, Young HA. Fenimore JM, et al. J Pathol. 2023 Jul;260(3):276-288. doi: 10.1002/path.6081. Epub 2023 Apr 27. J Pathol. 2023. PMID: 37185821 Free PMC article.

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