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ATM Inhibitor-8
ATM Inhibitor-8
ATM Inhibitor-8 (Compound 10r) is a potent, selective, and orally active ATM inhibitor with anti-tumor activity, characterized by an IC50 value of 1.15 nM [1].
Catalog No. T79305
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ATM Inhibitor-8
Catalog No. T79305
ATM Inhibitor-8 (Compound 10r) is a potent, selective, and orally active ATM inhibitor with anti-tumor activity, characterized by an IC50 value of 1.15 nM [1].
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
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| 5 mg | Inquiry | Backorder | |
| 50 mg | Inquiry | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | ATM Inhibitor-8 (Compound 10r) is a potent, selective, and orally active ATM inhibitor with anti-tumor activity, characterized by an IC50 value of 1.15 nM [1]. |
| In vitro | ATM Inhibitor-8 exhibits inhibitory activity against colorectal cancer cells (HCT116, SW620) and breast cancer cells (MCF-7) [1]. When combined with 4.22 |
| In vivo | ATM Inhibitor-8, when combined with Irinotecan (40 mg/kg), demonstrates a potent suppressive effect on tumor growth in the SW620 mouse model [1]. Moreover, ATM Inhibitor-8 (10 mg/kg, i.v.) exhibits favorable pharmacokinetic (PK) properties in Balb/c mice, as evidenced by its low plasma clearance, high plasma exposure, and excellent oral bioavailability [1]. |
| Molecular Weight | 462.59 |
| Formula | C26H34N6O2 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μ L DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μ L DMSO main solution, add 300 μ LPEG300 mix well and clarify, then add 50 more μ L Tween 80, mix well and clarify, then add 600 more μ LddH2O mix well and clarify
main solution, add 300 mix well and clarify, then add 50 more mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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