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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $38 | In Stock | |
10 mg | $54 | In Stock | |
25 mg | $68 | In Stock | |
50 mg | $81 | In Stock | |
100 mg | $123 | In Stock | |
200 mg | $179 | In Stock | |
1 mL x 10 mM (in DMSO) | $29 | In Stock |
Description | TBB (NSC-231634)(NSC-231634) is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2). |
Targets&IC50 | CK2:0.4 |
In vitro | Investigation of the inhibitory power of TBB against a panel of 33 protein kinases reveals the highest potency for CK2 (casein kinase 2) (human CK2: IC50=1.6 |
In vivo | In a mouse OIR model, treatment with TBB (60 mg/kg per day for 6 days), the most specific CK2 inhibitor known[4], reduces retinal neovascularization by approximately 60%. |
Kinase Assay | Kinase assay: Total kinase activity of CaMKII, determined in a standard 2 min assay (100 |
Cell Research | TBB is dissolved in DMSO and stored, and then diluted with appropriate media before use[2]. PC-3 or HeLa cells are cultured routinely in RPMI-1640 and DMEM media, respectively, which are supplemented with 10% FBS, Penicillin (100 U/mL) and Streptomycin (100 |
Alias | Casein Kinase II Inhibitor I, NSC 231634, 4,5,6,7-tetrabromobenzotriazole |
Molecular Weight | 434.71 |
Formula | C6HBr4N3 |
Cas No. | 17374-26-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 43.5 mg/mL (100 mM) Ethanol: 100 mM | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/Ethanol
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