tumor protein p53 (Q283350)

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mammalian protein found in Homo sapiens
  • Tumor suppressor p53
  • transformation-related protein 53
  • tumor supressor p53
  • TP53
  • mutant tumor protein 53
  • p53 tumor suppressor
  • antigen NY-CO-13
  • phosphoprotein p53
  • Tumor Suppressor Protein p53
  • cellular tumor antigen p53
  • tumor protein 53
  • p53
edit
Language Label Description Also known as
English
tumor protein p53
mammalian protein found in Homo sapiens
  • Tumor suppressor p53
  • transformation-related protein 53
  • tumor supressor p53
  • TP53
  • mutant tumor protein 53
  • p53 tumor suppressor
  • antigen NY-CO-13
  • phosphoprotein p53
  • Tumor Suppressor Protein p53
  • cellular tumor antigen p53
  • tumor protein 53
  • p53

Statements

image
P53.png
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0 references
has effect
DNA repair
0 references
molecular function
enzyme binding
determination method or standard
IPI
8 references
retrieved
8 April 2019
stated in
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Human topoisomerase IIalpha and IIbeta interact with the C-terminal region of p53
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Aprataxin, a novel protein that protects against genotoxic stress
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
The Bloom syndrome protein interacts and cooperates with p53 in regulation of transcription and cell growth control
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Regulation of cellular response to oncogenic and oxidative stress by Seladin-1
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
RFWD3-Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damage
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
p53 modulation of TFIIH–associated nucleotide excision repair activity
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
p53 is regulated by the lysine demethylase LSD1
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
protein binding
determination method or standard
IPI
310 references
retrieved
8 April 2019
stated in
MOZ increases p53 acetylation and premature senescence through its complex formation with PML
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Induction of SOX4 by DNA damage is critical for p53 stabilization and function
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
RNF125 is a ubiquitin-protein ligase that promotes p53 degradation
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
ASPP proteins specifically stimulate the apoptotic function of p53
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
ZNF385B is characteristically expressed in germinal center B cells and involved in B-cell apoptosis
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Disruption of FAT10-MAD2 binding inhibits tumor progression.
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
USP10 regulates p53 localization and stability by deubiquitinating p53
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
NUPR1 interacts with p53, transcriptionally regulates p21 and rescues breast epithelial cells from doxorubicin-induced genotoxic stress
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Molecular basis of Pirh2-mediated p53 ubiquitylation
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Binding and modulation of p53 by p300/CBP coactivators
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
The notch regulator MAML1 interacts with p53 and functions as a coactivator
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Modulation of p53 function by SET8-mediated methylation at lysine 382
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Trim24 targets endogenous p53 for degradation
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Aurora B Interacts with NIR-p53, Leading to p53 Phosphorylation in Its DNA-binding Domain and Subsequent Functional Suppression
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Nucleolar protein GLTSCR2 stabilizes p53 in response to ribosomal stresses
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Arginine methylation regulates the p53 response
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
NIR, an inhibitor of histone acetyltransferases, regulates transcription factor TAp63 and is controlled by the cell cycle
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
BRD7 is a candidate tumour suppressor gene required for p53 function
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
p53CSV, a novel p53-inducible gene involved in the p53-dependent cell-survival pathway
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
High mobility group protein-1 (HMG-1) is a unique activator of p53
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
LACE1 interacts with p53 and mediates its mitochondrial translocation and apoptosis
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
G9a and Glp methylate lysine 373 in the tumor suppressor p53
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Identification and characterization of two novel isoforms of Pirh2 ubiquitin ligase that negatively regulate p53 independent of RING finger domains
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Nucleophosmin regulates the stability and transcriptional activity of p53
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Regulation of p53 tetramerization and nuclear export by ARC
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Repression of p53 activity by Smyd2-mediated methylation
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
SVH-B interacts directly with p53 and suppresses the transcriptional activity of p53.
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
G-protein-coupled receptor kinase 5 phosphorylates p53 and inhibits DNA damage-induced apoptosis
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Critical role for Daxx in regulating Mdm2
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
A novel cofactor for p300 that regulates the p53 response
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Regulation of p53 activity in nuclear bodies by a specific PML isoform
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
p53 modulation of TFIIH–associated nucleotide excision repair activity
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Wild-type p53 binds to the TATA-binding protein and represses transcription
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
p53 has a direct apoptogenic role at the mitochondria
GOA
curator
UniProt
UniProt protein ID
P04637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Transcription factor TAFII250 promotes Mdm2-dependent turnover of p53
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Monoubiquitylation promotes mitochondrial p53 translocation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
VRK1 interacts with p53 forming a basal complex that is activated by UV-induced DNA damage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Adenoviral E1A targets Mdm4 to stabilize tumor suppressor p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Interferon-inducible protein 16: insight into the interaction with tumor suppressor p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1).
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Two domains of p53 interact with the TATA-binding protein, and the adenovirus 13S E1A protein disrupts the association, relieving p53-mediated transcriptional repression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
A Pin1/mutant p53 axis promotes aggressiveness in breast cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
PARP-1 binds E2F-1 independently of its DNA binding and catalytic domains, and acts as a novel coactivator of E2F-1-mediated transcription during re-entry of quiescent cells into S phase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Coordinated regulation of p53 apoptotic targets BAX and PUMA by SMAR1 through an identical MAR element
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Interaction of p53 with the human Rad51 protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structural features of human histone acetyltransferase p300 and its complex with p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Regulation of XIAP translation and induction by MDM2 following irradiation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Anti-apoptotic protein TCTP controls the stability of the tumor suppressor p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
A human protein-protein interaction network: a resource for annotating the proteome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Identification of differential proteins in nasopharyngeal carcinoma cells with p53 silence by proteome analysis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
An Arabidopsis immunophilin, AtFKBP12, binds to AtFIP37 (FKBP interacting protein) in an interaction that is disrupted by FK506
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
RYBP stabilizes p53 by modulating MDM2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
GNL3L depletion destabilizes MDM2 and induces p53-dependent G2/M arrest
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
p53 Modulates the exonuclease activity of Werner syndrome protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Differentiated embryo-chondrocyte expressed gene 1 regulates p53-dependent cell survival versus cell death through macrophage inhibitory cytokine-1.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
The DNA-binding domain mediates both nuclear and cytosolic functions of p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
p53 is regulated by the lysine demethylase LSD1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
PUMA couples the nuclear and cytoplasmic proapoptotic function of p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
COP9 signalosome subunit 6 stabilizes COP1, which functions as an E3 ubiquitin ligase for 14-3-3σしぐま
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Trim24 targets endogenous p53 for degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Functional interaction between p53 and the interferon-inducible nucleoprotein IFI 16
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Ribosomal protein S3: A multi-functional protein that interacts with both p53 and MDM2 through its KH domain
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Inhibition of Thr-55 phosphorylation restores p53 nuclear localization and sensitizes cancer cells to DNA damage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
An acetyl-methyl switch drives a conformational change in p53.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Acetylation of p53 stimulates miRNA processing and determines cell survival following genotoxic stress
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Transient Protein States in Designing Inhibitors of the MDM2-p53 Interaction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
An essential function of the extreme C-terminus of MDM2 can be provided by MDMX
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Wild-type p53 controls cell motility and invasion by dual regulation of MET expression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
BRD7 is a candidate tumour suppressor gene required for p53 function
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Twist and p53 reciprocally regulate target genes via direct interaction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Complex formation of the nonstructural protein 3 of hepatitis C virus with the p53 tumor suppressor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Evidence for self-association of the alternative sigma factor σしぐま54
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Targeting of p300/CREB binding protein coactivators by simian virus 40 is mediated through p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Aurora kinase-A inactivates DNA damage-induced apoptosis and spindle assembly checkpoint response functions of p73
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
High mobility group protein-1 (HMG-1) is a unique activator of p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
A "twist box" code of p53 inactivation: twist box: p53 interaction promotes p53 degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Protein kinase C delta regulates Ser46 phosphorylation of p53 tumor suppressor in the apoptotic response to DNA damage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
JMJD6 promotes colon carcinogenesis through negative regulation of p53 by hydroxylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
14-3-3ζぜーた turns TGF-βべーた's function from tumor suppressor to metastasis promoter in breast cancer by contextual changes of Smad partners from p53 to Gli2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Fludarabine treatment favors the retention of miR-485-3p by prostate cancer cells: implications for survival
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Identification of a second Nutlin-3 responsive interaction site in the N-terminal domain of MDM2 using hydrogen/deuterium exchange mass spectrometry
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Turning the RING domain protein MdmX into an active ubiquitin-protein ligase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
A stress response pathway regulates DNA damage through βべーた2-adrenoreceptors and βべーた-arrestin-1.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Camptothecin induces nuclear export of prohibitin preferentially in transformed cells through a CRM-1-dependent mechanism
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Mechanistic differences in the transcriptional activation of p53 by 14-3-3 isoforms
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
p53 has a direct apoptogenic role at the mitochondria
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
MDM4 binds ligands via a mechanism in which disordered regions become structured
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
AXIN is an essential co-activator for the promyelocytic leukemia protein in p53 activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Identification and characterization of the novel protein CCDC106 that interacts with p53 and promotes its degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structure of the p53 C-terminus bound to 14-3-3: implications for stabilization of the p53 tetramer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Attenuation of DNA damage checkpoint by PBK, a novel mitotic kinase, involves protein-protein interaction with tumor suppressor p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
NS3 protein of Hepatitis C virus associates with the tumour suppressor p53 and inhibits its function in an NS3 sequence-dependent manner
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Identification of mutations in p53 that affect its binding to SV40 large T antigen by using the yeast two-hybrid system
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Rotavirus-encoded nonstructural protein 1 modulates cellular apoptotic machinery by targeting tumor suppressor protein p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Inhibition of p53 DNA binding by human papillomavirus E6 proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
ATM-mediated phosphorylation activates the tumor-suppressive function of B56γがんま-PP2A
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Characterization of an E1A-CBP interaction defines a novel transcriptional adapter motif (TRAM) in CBP/p300
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
The yeast two-hybrid system reveals no interaction between p73 alpha and SV40 large T-antigen
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Requirement of E6AP and the features of human papillomavirus E6 necessary to support degradation of p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
NUMB controls p53 tumour suppressor activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Tip60 and p400 are both required for UV-induced apoptosis but play antagonistic roles in cell cycle progression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
VRK1 and AURKB form a complex that cross inhibit their kinase activity and the phosphorylation of histone H3 in the progression of mitosis.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Bilateral inhibition of HAUSP deubiquitinase by a viral interferon regulatory factor protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structural basis for the methylation site specificity of SET7/9
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structural basis for subversion of cellular control mechanisms by the adenoviral E1A oncoprotein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Molecular basis of Pirh2-mediated p53 ubiquitylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Aurora-A phosphorylates hnRNPK and disrupts its interaction with p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structural basis of substrate methylation and inhibition of SMYD2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
AIMP2/p38, the scaffold for the multi-tRNA synthetase complex, responds to genotoxic stresses via p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Polo-like kinase 1 regulates mitotic arrest after UV irradiation through dephosphorylation of p53 and inducing p53 degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Towards a proteome-scale map of the human protein–protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Molecular recognition of p53 and MDM2 by USP7/HAUSP
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Specific domains of nucleolin interact with Hdm2 and antagonize Hdm2-mediated p53 ubiquitination
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
MAGE-RING Protein Complexes Comprise a Family of E3 Ubiquitin Ligases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Acetylation is indispensable for p53 activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
The E3 Ligase RING1 Targets p53 for Degradation and Promotes Cancer Cell Proliferation and Survival.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Crystal structure of SV40 large T-antigen bound to p53: interplay between a viral oncoprotein and a cellular tumor suppressor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
hCAS/CSE1L associates with chromatin and regulates expression of select p53 target genes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Synaptonemal complex formation and meiotic checkpoint signaling are linked to the lateral element protein Red1.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Atg7 modulates p53 activity to regulate cell cycle and survival during metabolic stress
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Lysine activation and functional analysis of E2-mediated conjugation in the SUMO pathway.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Synergistic activation of transcription by CBP and p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
A new role of NUAK1: directly phosphorylating p53 and regulating cell proliferation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
DBC1 is a negative regulator of SIRT1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Modulation of the vitamin D3 response by cancer-associated mutant p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
PACT is a negative regulator of p53 and essential for cell growth and embryonic development
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
FKBP25, a novel regulator of the p53 pathway, induces the degradation of MDM2 and activation of p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
S100 proteins interact with the N-terminal domain of MDM2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
p53 opens the mitochondrial permeability transition pore to trigger necrosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Proteasome activator PA28 gamma regulates p53 by enhancing its MDM2-mediated degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
The DEAD box protein p68: a novel transcriptional coactivator of the p53 tumour suppressor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Nucleophosmin regulates the stability and transcriptional activity of p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
PBK/TOPK interacts with the DBD domain of tumor suppressor p53 and modulates expression of transcriptional targets including p21
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Regulation of p53 tetramerization and nuclear export by ARC
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Viral immune modulators perturb the human molecular network by common and unique strategies
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
A molecular basis for phosphorylation-dependent SUMO conjugation by the E2 UBC9.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Negative regulation of p53 functions by Daxx and the involvement of MDM2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
determination method or standard
IPI
retrieved
8 April 2019
stated in
Skp2B attenuates p53 function by inhibiting prohibitin