(Translated by https://www.hiragana.jp/)
Impact of chronic hepatitis B and interferon-α therapy on growth of children | DIAL.pr - BOREAL

User menu

Accès à distance ? S'identifier sur le proxy UCLouvain

Impact of chronic hepatitis B and interferon-αあるふぁ therapy on growth of children

Primary tabs

Comanor, L. Minor, J. Conjeevaram, H.S. Roberts, E.A. Alvarez, F. Sokal, Etienne [UCL]

Interferon-αあるふぁ (IFN) has been approved as treatment for children with chronic hepatitis B (CHB). The aims of this study were to assess the impact on children's growth of the disease itself and of IFN treatment. The growth of 142 children with CHB (70 IFN-treated, 72 untreated) was monitored for a minimum of one year. Regression analysis models were used to determine which of the variables most affected children's growth. After adjusting for racial differences, the population of 142 children with CHB had a mean baseline height for age percentile of 39 and a mean baseline weight for age percentile of 38, which were significantly different (P < 0.0001) from the 50th percentiles of their respective reference populations. The height for age Z score of untreated children was inversely correlated with serum hepatitis B virus DNA and aspartate aminotransferase levels, and the weight for age Z score was inversely correlated with serum hepatitis B virus DNA levels. While undergoing IFN therapy, children displayed a "U-shaped" growth pattern, such that height for age and weight for age Z scores at 3 or 6 months were lower than scores at baseline or 12 months. In this study the average child with CHB showed compromised growth even in the absence of IFN therapy. During IFN therapy, children's growth was temporarily disrupted.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2001
Language Anglais
Journal information "Journal of Viral Hepatitis" - Vol. 8, no. 2, p. 139-147 (2001)
Peer reviewed yes
Publisher Wiley-Blackwell Publishing Ltd.
e-issn 1365-2893
issn 1352-0504
Publication status Publié
Affiliations UCL - (SLuc) Centre de pathologie anorectale de l'enfant
UCL - (SLuc) Centre de thérapie tissulaire et cellulaire
UCL - MD/GYPE - Département de gynécologie, d'obstétrique et de pédiatrie
UCL - (SLuc) Service de gastro-entérologie et hépatologie pédiatrique
Keywords Chronic hepatitis B ; Growth ; HBV DNA ; interferon-αあるふぁ therapy ; Paediatrics
Links
  1. Novy Margaret A., Schwarz Kathleen B., Nutritional considerations and management of the child with liver disease, 10.1016/s0899-9007(97)00045-2
  2. Sokol RJ, Am J Clin Nutr, 52, 203 (1990)
  3. Polito C, Acta Paediatr Scand, 80, 1231 (1991)
  4. Vegnente A, J Pediatr Gastroenterol Nutr, 14, 123 (1992)
  5. Gottrand F., Michaud L., Guimber D., Ategbo S., Dubar G., Turck D., Farriaux J. P., Influence of recombinant interferon alpha on nutritional status and growth pattern in children with chronic viral hepatitis, 10.1007/s004310050528
  6. Jara Paloma, Bortolotti Flavia, Interferon-αあるふぁ Treatment of Chronic Hepatitis B in Childhood: A Consensus Advice Based on Experience in European Children : , 10.1097/00005176-199908000-00012
  7. Hermanussen Michael, The Analysis of Short-Term Growth, 10.1159/000023127
  8. Barr George D., Height and Weight of 7,500 : Children of Three Skin Colors, 10.1001/archpedi.1972.02110180068009
  9. 9 National Center for Health Statistics .NCHS growth curves for children birth-18 years. United States DHEW Publication no. (PHS) 78-1650. Hyaltsville, MD: U.S. Department of Health, Education and Welfare, Public Health Service, National Center for Health Statistics, 1977 .
  10. Sokal Etienne Marc, Conjeevaram Hari S., Roberts Eve A., Alvarez Fernando, Bern Elana M., Goyens Philippe, Rosenthal Philip, Lachaux Alain, Shelton Mark, Sarles Jacques, Interferon alfa therapy for chronic hepatitis B in children: A multinational randomized controlled trial☆, 10.1016/s0016-5085(98)70318-x
  11. 11 Pediatric Multiphasic Screening Study Final Report . Volume 1, Bureau of Disease Prevention and Environmental Control Public Health Service. Contract No PH, 86-67-251, 1970 .
  12. Minor JM, J Biopharm Statist, 6, 83 (1996)
  13. Hamill PV, Am J Clin Nutr, 32, 607 (1979)
  14. 14 MW Hilgartner, SM Donfield, and HS Lynnet al. The effect of plasma HIV RNA and CD4+ T-lymphocytes on growth measurements of hemophiliac boys and adolescents . Presented at the American Pediatric Society and Society for Pediatric Research, San Francisco, CA, May 1999 .
  15. Hostetter MK, N Engl J Med, 325, 479 (1991)
  16. Miller Laurie C., Developmental and Nutritional Status of Internationally Adopted Children, 10.1001/archpedi.1995.02170130042009
  17. Benoit Teresa C., Romanian Adoption : The Manitoba Experience, 10.1001/archpedi.1996.02170370056008
  18. Albers L. H., Health of children adopted from the former Soviet Union and Eastern Europe. Comparison with preadoptive medical records, 10.1001/jama.278.11.922
  19. Markhorst E Lopriore, DG, Diffuse neonatal haemangiomatosis: new views on diagnostic criteria and prognosis, 10.1080/08035259950170682
Bibliographic reference Comanor, L. ; Minor, J. ; Conjeevaram, H.S. ; Roberts, E.A. ; Alvarez, F. ; et. al. Impact of chronic hepatitis B and interferon-αあるふぁ therapy on growth of children. In: Journal of Viral Hepatitis, Vol. 8, no. 2, p. 139-147 (2001)
Permanent URL http://hdl.handle.net/2078.1/164479