|
Gene Symbol(s):
|
IL10
|
| Organism: |
Homo sapiens |
| View Gene in Tree |
|
| Gene Name: |
Interleukin-10
|
| Gene ID: |
HGNC:5962
|
| Protein ID: |
P22301
|
| Enhancers: |
View enhancers for HUMAN|HGNC=5962|UniProtKB=P22301 |
| Genetic Variant Annotation: |
Annoq |
| Persistent Id: |
PTN009232513 |
| Alternate Ids: |
| ENST00000423557(Ensembl_TRS) |
U16720(EMBL) |
| CSIF(Synonym) |
IL10(Symbol) |
| AAK38162(EMBL-CDS) |
CHEMBL3712920(ChEMBL) |
| HGNC:5962(HGNC) |
3586(GeneID) |
| 124292(GI) |
ENSG00000136634(Ensembl) |
| IL10_HUMAN(UniProtKB-ID) |
NM_000572(refSeq) |
| 614395(MIM) |
ENSP00000412237(Ensembl_PRO) |
|
Show All
|
|
| GO MF Complete: |
growth factor activity, protein binding, interleukin-10 receptor binding, protein dimerization activity, cytokine activity
|
| GO BP Complete: |
negative regulation of interleukin-1 production, cytoplasmic sequestering of NF-kappaB, positive regulation of DNA-binding transcription factor activity, response to molecule of bacterial origin, negative regulation of chronic inflammatory response to antigenic stimulus, positive regulation of DNA-templated transcription, negative regulation of membrane protein ectodomain proteolysis, chronic inflammatory response to antigenic stimulus, positive regulation of macrophage activation, negative regulation of chemokine (C-C motif) ligand 5 production, positive regulation of immunoglobulin production, negative regulation of cytokine production involved in immune response, response to carbon monoxide, negative regulation of type II interferon production, response to inactivity, negative regulation of interferon-alpha production, negative regulation of tumor necrosis factor production, B cell differentiation, regulation of synapse organization, negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway, negative regulation of inflammatory response, positive regulation of plasma cell differentiation, branching involved in labyrinthine layer morphogenesis, B cell proliferation, negative regulation of mitotic cell cycle, negative regulation of vascular associated smooth muscle cell proliferation, defense response to bacterium, negative regulation of nitric oxide biosynthetic process, positive regulation of receptor signaling pathway via JAK-STAT, negative regulation of interleukin-6 production, negative regulation of autophagy, negative regulation of interleukin-8 production, regulation of gene expression, response to activity, endothelial cell apoptotic process, interleukin-10-mediated signaling pathway, negative regulation of cell population proliferation, hemopoiesis, negative regulation of MHC class II biosynthetic process, positive regulation of cell cycle, positive regulation of miRNA transcription, response to xenobiotic stimulus, positive regulation of transcription by RNA polymerase II, negative regulation of cytokine activity, positive regulation of MHC class II biosynthetic process, defense response to protozoan, cellular response to estradiol stimulus, liver regeneration, negative regulation of B cell proliferation, response to insulin, positive regulation of vascular associated smooth muscle cell proliferation, response to glucocorticoid, regulation of isotype switching, negative regulation of interleukin-18 production, negative regulation of myeloid dendritic cell activation, positive regulation of signaling receptor activity, regulation of response to wounding, positive regulation of sprouting angiogenesis, type 2 immune response, cellular response to lipopolysaccharide, cellular response to hepatocyte growth factor stimulus, negative regulation of T cell proliferation, negative regulation of apoptotic process, positive regulation of heterotypic cell-cell adhesion, positive regulation of B cell apoptotic process, negative regulation of heterotypic cell-cell adhesion, positive regulation of endothelial cell proliferation, leukocyte chemotaxis, negative regulation of interleukin-12 production, negative regulation of cytokine production, positive regulation of cytokine production
|
| GO CC Complete: |
extracellular space, extracellular region
|
| Reactome Pathways: |
FCGR3A-mediated IL10 synthesis, Leishmania parasite growth and survival, Interleukin-10 signaling, Signaling by Interleukins, Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation, Signaling by ALK in cancer, Disease, Interleukin-12 signaling, Anti-inflammatory response favouring Leishmania parasite infection, CD163 mediating an anti-inflammatory response, Leishmania infection, Infectious disease, Interleukin-4 and Interleukin-13 signaling, Diseases of signal transduction by growth factor receptors and second messengers, Cytokine Signaling in Immune system, Parasitic Infection Pathways, Immune System, Signaling by ALK fusions and activated point mutants, Interleukin-12 family signaling
|
|
