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  1. The interactions between bacterial pathogens and host cells are characterized by a multitude of complexities, leading to a wide range of heterogeneous outcomes. Despite extensive research, we still have a limi...

    Authors: Narendra K. Dewangan, Sayed Golam Mohiuddin, Shayne Sensenbach, Prashant Karki and Mehmet A. Orman
    Citation: BMC Biology 2024 22:256
    Content type: Research article Published on:

  2. Evolutionary adaptation drives organismal adjustments to environmental pressures, exemplified in the diverse morphological and ecological adaptations seen in Decapoda crustaceans, particularly brachyuran crabs...

    Authors: Yin Zhang, Ye Yuan, Mengqian Zhang, Xiaoyan Yu, Bixun Qiu, Fangchun Wu, Douglas R. Tocher, Jiajia Zhang, Shaopan Ye, Wenxiao Cui, Jonathan Y. S. Leung, Mhd Ikhwanuddin, Waqas Waqas, Tariq Dildar and Hongyu Ma
    Citation: BMC Biology 2024 22:255
    Content type: Research Published on:

  3. The 3′ untranslated region (3′UTR) plays a crucial role in determining mRNA stability, localisation, translation and degradation. Cap analysis of gene expression (CAGE), a method for the detection of capped 5′...

    Authors: Nejc Haberman, Holly Digby, Rupert Faraway, Rebecca Cheung, Anob M. Chakrabarti, Andrew M. Jobbins, Callum Parr, Kayoko Yasuzawa, Takeya Kasukawa, Chi Wai Yip, Masaki Kato, Hazuki Takahashi, Piero Carninci, Santiago Vernia, Jernej Ule, Christopher R. Sibley…
    Citation: BMC Biology 2024 22:254
    Content type: Research Published on:

  4. NorR, as a single-target regulator, has been demonstrated to be involved in NO detoxification in bacteria under anaerobic conditions. Here, the norR gene was identified and deleted in the genome of Vibrio alginol...

    Authors: Tongxian Chen, Xiaoling Zhou, Ruonan Feng, Shuhao Shi, Xiyu Chen, Bingqi Wei, Zhong Hu and Tao Peng
    Citation: BMC Biology 2024 22:253
    Content type: Research article Published on:

  5. Understanding how genes function to heal wounds and restore lost tissue is essential for studying regeneration. Whole-mount in situ hybridization (WISH) is a powerful and widely used technique to visualize the...

    Authors: Carlos Guerrero-Hernández, Viraj Doddihal, Frederick G. Mann Jr. and Alejandro Sánchez Alvarado
    Citation: BMC Biology 2024 22:252
    Content type: Methodology article Published on:

  7. Climate change is driving increased extreme weather events that can impact ecology by moderating host–pathogen interactions. To date, few studies have explored how cold snaps affect disease prevalence and prol...

    Authors: Niamh McCartan, Jeremy Piggott, Sadie DiCarlo and Pepijn Luijckx
    Citation: BMC Biology 2024 22:250
    Content type: Research article Published on:

  8. The Leishmania genome harbors formerly active short interspersed degenerated retroposons (SIDERs) representing the largest family of repetitive elements among trypanosomatids. Their substantial expansion in Leish...

    Authors: Gabriel Reis Ferreira, Jean-Guillaume Emond-Rheault, Lysangela Alves, Philippe Leprohon, Martin A. Smith and Barbara Papadopoulou
    Citation: BMC Biology 2024 22:249
    Content type: Research Published on:

  9. Accurate prediction of compound-protein interaction (CPI) plays a crucial role in drug discovery. Existing data-driven methods aim to learn from the chemical structures of compounds and proteins yet ignore the...

    Authors: Wen Tao, Xuan Lin, Yuansheng Liu, Li Zeng, Tengfei Ma, Ning Cheng, Jing Jiang, Xiangxiang Zeng and Sisi Yuan
    Citation: BMC Biology 2024 22:248
    Content type: Research Published on:

  10. Mitochondria-endoplasmic reticulum membrane contact (MERC) is an important mode of intercellular organelle communication and plays a crucial role in adipose tissue metabolism. Functionality of Hoxa5 is an impo...

    Authors: Qi Chen, Zeyu Ren, Liping Dang, Zunhai Liu, Simeng Wang, Xinhao Chen, Guiping Qiu and Chao Sun
    Citation: BMC Biology 2024 22:247
    Content type: Research article Published on:

  11. The role of histone methyltransferase SETDB1 in renal ischemia–reperfusion (I/R) injury has not been explored yet. This study aims to investigate the potential mechanism of SETDB1 in regulating renal I/R injur...

    Authors: Kang Xia, Yumin Hui, Long Zhang, Qiangmin Qiu, Jiacheng Zhong, Hui Chen, Xiuheng Liu, Lei Wang and Zhiyuan Chen
    Citation: BMC Biology 2024 22:246
    Content type: Research article Published on:

  12. While complex dog–human coexistence has been deeply investigated, there is a relative scarcity of similar knowledge regarding dog–dog interactions. Social learning, a fundamental synchronizing mechanism betwee...

    Authors: Csenge Anna Lugosi, Kata Mária Udvarhelyi-Tóth, Petra Dobos and Péter Pongrácz
    Citation: BMC Biology 2024 22:245
    Content type: Research article Published on:

  13. Thymosin beta 4 (Tβべーた4) is a monomeric actin-binding protein that plays many roles in biological activities. However, some studies on the role of Tβべーた4 in central axon regeneration have yielded contradictory resul...

    Authors: Zheng Song, Along Han and Bing Hu
    Citation: BMC Biology 2024 22:244
    Content type: Research article Published on:

  14. The snake genera Atropoides, Cerrophidion, and Metlapilcoatlus form a clade of neotropical pit vipers distributed across Mexico and Central America. This study evaluated the myotoxic and neurotoxic effects of nin...

    Authors: Lee Jones, Mimi Lay, Edgar Neri-Castro, Vanessa Zarzosa, Wayne C. Hodgson, Matthew Lewin and Bryan G. Fry
    Citation: BMC Biology 2024 22:243
    Content type: Research Published on:

  15. Single-domain von Willebrand factor type C (SVWC) constitute a protein family predominantly identified in arthropods, characterized by a SVWC domain and involved in diverse physiological processes such as host...

    Authors: Ting Tang, Siyu Sun, Ruirui Wang, Mengnan Li, Yongpeng Wang, Feifei Li, Yun Wang and Fengsong Liu
    Citation: BMC Biology 2024 22:242
    Content type: Research article Published on:

  16. The family Lauraceae is subdivided into six main lineages: Caryodaphnopsideae, Cassytheae, Cryptocaryeae, Hypodaphnideae, Laureae, and Neocinnamomeae. However, phylogenetic relationships among these lineages h...

    Authors: Yu Song, Qun-Fei Yu, Di Zhang, Li-Gang Chen, Yun-Hong Tan, Wen Zhu, Hua-Long Su, Xin Yao, Chao Liu and Richard T. Corlett
    Citation: BMC Biology 2024 22:241
    Content type: Research article Published on:

  17. The rumen microbiome plays an essential role in maintaining ruminants’ growth and performance even under extreme environmental conditions, however, which factors influence rumen microbiome stability when rumin...

    Authors: Wei Guo, Mi Zhou, Fuyong Li, André Luis Alves Neves, Tao Ma, Sisi Bi, Weiwei Wang, Ruijun Long and Le Luo Guan
    Citation: BMC Biology 2024 22:240
    Content type: Research article Published on:

  18. Botrytis cinerea is a broad-host-range pathogen causing gray mold disease and significant yield losses of numerous crops. However, the mechanisms underlying its rapid invasion and efficient killing of plant cells...

    Authors: Jinfeng Wei, Qian Zhou, Jing Zhang, Mingde Wu, Guoqing Li and Long Yang
    Citation: BMC Biology 2024 22:239
    Content type: Research Published on:

  19. Working memory (WM), a core component of executive functions, relies on a dedicated brain system that maintains and stores information in the short term. While extensive neuroimaging research has identified a ...

    Authors: Xiaotao Xu, Han Zhao, Yu Song, Huanhuan Cai, Wenming Zhao, Jin Tang, Jiajia Zhu and Yongqiang Yu
    Citation: BMC Biology 2024 22:238
    Content type: Research article Published on:

  20. As a potential model organism for studies of environmental and cell biology, Paramecium duboscqui is a special euryhaline species of Paramecium that can be found in fresh, brackish, or marine water in natural sal...

    Authors: Yu Fu, Ping Ni, Ying Zhang, Fasheng Liang, Naomi A. Stover and Lifang Li
    Citation: BMC Biology 2024 22:237
    Content type: Research Published on:

  21. Authors: Yuanyuan Liu, Jian Li, Chenhui Wang, Jiangbo Li, Kai Luo, Kang Tao, Yuan Tian, Xiang Song, Zhifang Zhai, Yuandong Tao, Jia You, Lihua Wu, Wenqian Li, Yuanyuan Jiao, Rongya Yang and Mingwang Zhang
    Citation: BMC Biology 2024 22:236
    Content type: Author Correction Published on:

    The original article was published in BMC Biology 2024 22:192

  22. The transition from explanative modeling of fitted data to the predictive modeling of unseen data for systems biology endeavors necessitates the effective recovery of reaction parameters. Yet, the relative eff...

    Authors: Hock Chuan Yeo, Varsheni Vijay and Kumar Selvarajoo
    Citation: BMC Biology 2024 22:235
    Content type: Research article Published on:

  23. Pangolins are the only mammals that have overlapping scales covering most of their bodies, and they play a crucial role in the ecosystem, biological research, and human health and disease. Previous studies ind...

    Authors: Xuechen Tian, Li Chen, Jinfeng Zhou, Enbo Wang, Mu Wang, Nicholas Jakubovics, Jing Li, Kunping Song, King Tong Lau, Klaus-Peter Koepfli, Siyuan Zhang, Geok Yuan Annie Tan, Yixin Yang and Siew Woh Choo
    Citation: BMC Biology 2024 22:234
    Content type: Research article Published on:

  24. Drug-drug interactions (DDIs) can result in unexpected pharmacological outcomes, including adverse drug events, which are crucial for drug discovery. Graph neural networks have substantially advanced our abili...

    Authors: Yaojia Chen, Jiacheng Wang, Quan Zou, Mengting Niu, Yijie Ding, Jiangning Song and Yansu Wang
    Citation: BMC Biology 2024 22:233
    Content type: Methodology Published on:

  25. Juvenile hormone (JH) is an insect-exclusive hormone involved in regulating diverse aspects of insect physiology, and the evolution of its diverse function is widely interesting. Studying embryogenesis in basa...

    Authors: Ya-Nan Lv, Mei Zeng, Zi-Yu Yan, Pei-Yan Zhang, Ning Ban, Dong-Wei Yuan, Sheng Li, Yun-Xia Luan and Yu Bai
    Citation: BMC Biology 2024 22:232
    Content type: Research Published on:

  26. Organisms have evolved a range of phenotypic and genetic adaptations to live in different environments along an altitudinal gradient. Herein, we studied the widely distributed Chinese toad, Bufo gargarizans, as a...

    Authors: Yonggang Niu, Xuejing Zhang, Haiying Zhang, Shengkang Men, Tisen Xu, Li Ding, Xiangyong Li, Lei Wang, Huisong Wang, Kenneth B. Storey and Qiang Chen
    Citation: BMC Biology 2024 22:231
    Content type: Research article Published on:

  27. Evolutionary radiation is widely recognized as a mode of species diversification, but the drivers of the rapid diversification of fungi remain largely unknown. Here, we used Amanitaceae, one of the most divers...

    Authors: Qing Cai, Jean Evans I. Codjia, Bart Buyck, Yang-Yang Cui, Martin Ryberg, Nourou S. Yorou and Zhu L. Yang
    Citation: BMC Biology 2024 22:230
    Content type: Research article Published on:

  28. Mitochondrial genes and nuclear genes cooperate closely to maintain the functions of mitochondria, especially in the oxidative phosphorylation (OXPHOS) pathway. However, mitochondrial genes among arthropod lin...

    Authors: Yiyuan Li, Gregg W. C. Thomas, Stephen Richards, Robert M. Waterhouse, Xin Zhou and Michael E. Pfrender
    Citation: BMC Biology 2024 22:229
    Content type: Research article Published on:

  29. Authors: Siau Wei Bai, Maria Teresa Herrera-Abreu, Jennifer L Rohn, Victor Racine, Virginia Tajadura, Narendra Suryavanshi, Stephanie Bechtel, Stefan Wiemann, Buzz Baum and Anne J Ridley
    Citation: BMC Biology 2024 22:228
    Content type: Author Correction Published on:

    The original article was published in BMC Biology 2011 9:54

  30. Accurate and robust drug response prediction is of utmost importance in precision medicine. Although many models have been developed to utilize the representations of drugs and cancer cell lines for predicting...

    Authors: Xiaoqiong Xia, Chaoyu Zhu, Fan Zhong and Lei Liu
    Citation: BMC Biology 2024 22:227
    Content type: Research article Published on:

  31. Drug repurposing is a promising approach in the field of drug discovery owing to its efficiency and cost-effectiveness. Most current drug repurposing models rely on specific datasets for training, which limits...

    Authors: Jinhang Wei, Linlin Zhuo, Xiangzheng Fu, XiangXiang Zeng, Li Wang, Quan Zou and Dongsheng Cao
    Citation: BMC Biology 2024 22:226
    Content type: Research Published on:

  32. Homologous recombination deficiency (HRD) is recognized as a pan-cancer predictive biomarker that potentially indicates who could benefit from treatment with PARP inhibitors (PARPi). Despite its clinical signi...

    Authors: Chiara Maria Lavinia Loeffler, Omar S. M. El Nahhas, Hannah Sophie Muti, Zunamys I. Carrero, Tobias Seibel, Marko van Treeck, Didem Cifci, Marco Gustav, Kevin Bretz, Nadine T. Gaisa, Kjong-Van Lehmann, Alexandra Leary, Pier Selenica, Jorge S. Reis-Filho, Nadina Ortiz-Bruechle and Jakob Nikolas Kather
    Citation: BMC Biology 2024 22:225
    Content type: Research article Published on:

  34. The phylum Nematoda is incredibly diverse and includes many parasites of humans, livestock, and plants. Peptide-activated G protein-coupled receptors (GPCRs) are central to the regulation of physiology and num...

    Authors: Luca Golinelli, Ellen Geens, Allister Irvine, Ciaran J. McCoy, Elke Vandewyer, Louise E. Atkinson, Angela Mousley, Liesbet Temmerman and Isabel Beets
    Citation: BMC Biology 2024 22:223
    Content type: Research article Published on:

  35. Abnormalities of in utero testis development are strongly associated with reproductive health conditions, including male infertility and testis cancer. In mouse testes, SOX9 and FGF9 support Sertoli cell developm...

    Authors: Rheannon O. Blücher, Rachel S. Lim, Matthew E. Ritchie and Patrick S. Western
    Citation: BMC Biology 2024 22:222
    Content type: Research article Published on:

  36. The growth factor receptor bound protein 7 (Grb7) family of signalling adaptor proteins comprises Grb7, Grb10 and Grb14. Each can interact with the insulin receptor and other receptor tyrosine kinases, where G...

    Authors: Kim Moorwood, Florentia M. Smith, Alastair S. Garfield, Michael Cowley, Lowenna J. Holt, Roger J. Daly and Andrew Ward
    Citation: BMC Biology 2024 22:221
    Content type: Research article Published on:

  37. Eukaryotic cells are highly compartmentalized by a variety of organelles that carry out specific cellular processes. The position of these organelles within the cell is elaborately regulated and vital for thei...

    Authors: Christopher Schmied, Michael Ebner, Paula Samsó, Rozemarijn Van Der Veen, Volker Haucke and Martin Lehmann
    Citation: BMC Biology 2024 22:220
    Content type: Methodology article Published on:

  38. Small RNA (sRNAs)- mediated RNA silencing is emerging as a key player in host-microbe interactions. However, its role in fungus-plant interactions relevant to biocontrol of plant diseases is yet to be explored...

    Authors: Edoardo Piombo, Ramesh Raju Vetukuri, Naga Charan Konakalla, Pruthvi B. Kalyandurg, Poorva Sundararajan, Dan Funck Jensen, Magnus Karlsson and Mukesh Dubey
    Citation: BMC Biology 2024 22:219
    Content type: Research article Published on:

  39. RNA-sequencing technology provides an effective tool for understanding miRNA regulation in complex human diseases, including cancers. A large number of computational methods have been developed to make use of ...

    Authors: Junpeng Zhang, Lin Liu, Xuemei Wei, Chunwen Zhao, Yanbi Luo, Jiuyong Li and Thuc Duy Le
    Citation: BMC Biology 2024 22:218
    Content type: Methodology article Published on:

  40. Diplomonads are anaerobic flagellates classified within Metamonada. They contain both host-associated commensals and parasites that reside in the intestinal tracts of animals, including humans (e.g., Giardia inte...

    Authors: Monika M. Wiśniewska, Eric D. Salomaki, Jeffrey D. Silberman, Kristina X. Terpis, Eva Mazancová, Petr Táborský, Vasana Jinatham, Eleni Gentekaki, Ivan Čepička and Martin Kolisko
    Citation: BMC Biology 2024 22:217
    Content type: Research article Published on:

  42. Zoology’s dark matter comprises hyperdiverse, poorly known taxa that are numerically dominant but largely unstudied, even in temperate regions where charismatic taxa are well understood. Dark taxa are everywhe...

    Authors: Emily Hartop, Leshon Lee, Amrita Srivathsan, Mirkka Jones, Pablo Peña-Aguilera, Otso Ovaskainen, Tomas Roslin and Rudolf Meier
    Citation: BMC Biology 2024 22:215
    Content type: Research Published on:

  43. The development of sequence-specific precision treatments like CRISPR gene editing therapies for Duchenne muscular dystrophy (DMD) requires sequence humanized animal models to enable the direct clinical transl...

    Authors: Yu C. J. Chey, Mark A. Corbett, Jayshen Arudkumar, Sandra G. Piltz, Paul Q. Thomas and Fatwa Adikusuma
    Citation: BMC Biology 2024 22:214
    Content type: Research Published on:

  45. Wnt signaling pathways play crucial roles in animal development. They establish embryonic axes, specify cell fates, and regulate tissue morphogenesis from the early embryo to organogenesis. It is becoming incr...

    Authors: Bruno C. Vellutini, José M. Martín-Durán, Aina Børve and Andreas Hejnol
    Citation: BMC Biology 2024 22:212
    Content type: Research article Published on:

  46. Phosphorus-solubilizing bacteria (PSB) are vital in converting insoluble phosphorus into a soluble form that plants can readily absorb and utilize in soil. While previous studies have mainly focused on the ext...

    Authors: Kaihong Bai, Wanying Wang, Jingnan Zhang, Pei Yao, Chuanying Cai, Zimei Xie, Laixin Luo, Tingting Li and Zhenlong Wang
    Citation: BMC Biology 2024 22:211
    Content type: Research Published on:

  48. Neutrophils, the most abundant leukocytes circulating in blood, contribute to host defense and play a significant role in chronic inflammatory disorders. They can release their DNA in the form of extracellular...

    Authors: Manijeh Khanmohammadi, Habiba Danish, Nadia Chandra Sekar, Sergio Aguilera Suarez, Chanly Chheang, Karlheinz Peter, Khashayar Khoshmanesh and Sara Baratchi
    Citation: BMC Biology 2024 22:209
    Content type: Research Published on:

  49. The natural light environment is far more complex than that experienced by animals under laboratory conditions. As a burrowing species, wild mice are able to self-modulate their light exposure, a concept known...

    Authors: Laura C. E. Steel, Shu K. E. Tam, Laurence A. Brown, Russell G. Foster and Stuart N. Peirson
    Citation: BMC Biology 2024 22:208
    Content type: Research article Published on:

  50. The importance of parental diet in relation to eventual offspring health is increasing in prominence due to the increased frequency of parents of reproductive age consuming poor diets. Whilst maternal health a...

    Authors: Hannah L. Morgan, Nader Eid, Nadine Holmes, Sonal Henson, Victoria Wright, Clare Coveney, Catherine Winder, Donna M. O’Neil, Warwick B. Dunn, David J. Boocock and Adam J. Watkins
    Citation: BMC Biology 2024 22:207
    Content type: Research article Published on:
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