S Wikipedije, slobodne enciklopedije
Protein 80 sa upredenom zavojnicom jest protein koji je kod ljudi kodiran genom CCDC80 sa hromosoma 3 .[ 5] [ 6] [ 7]
Dužina polipeptidnog lanca je 950 aminokiselina , а molekulska težina 108.174 Da .[ 8]
10 20 30 40 50 MTWRMGPRFT MLLAMWLVCG SEPHPHATIR GSHGGRKVPL VSPDSSRPAR FLRHTGRSRG IERSTLEEPN LQPLQRRRSV PVLRLARPTE PPARSDINGA AVRPEQRPAA RGSPREMIRD EGSSARSRML RFPSGSSSPN ILASFAGKNR VWVISAPHAS EGYYRLMMSL LKDDVYCELA ERHIQQIVLF HQAGEEGGKV RRITSEGQIL EQPLDPSLIP KLMSFLKLEK GKFGMVLLKK TLQVEERYPY PVRLEAMYEV IDQGPIRRIE KIRQKGFVQK CKASGVEGQV VAEGNDGGGG AGRPSLGSEK KKEDPRRAQV PPTRESRVKV LRKLAATAPA LPQPPSTPRA TTLPPAPATT VTRSTSRAVT VAARPMTTTA FPTTQRPWTP SPSHRPPTTT EVITARRPSV SENLYPPSRK DQHRERPQTT RRPSKATSLE SFTNAPPTTI SEPSTRAAGP GRFRDNRMDR REHGHRDPNV VPGPPKPAKE KPPKKKAQDK ILSNEYEEKY DLSRPTASQL EDELQVGNVP LKKAKESKKH EKLEKPEKEK KKKMKNENAD KLLKSEKQMK KSEKKSKQEK EKSKKKKGGK TEQDGYQKPT NKHFTQSPKK SVADLLGSFE GKRRLLLITA PKAENNMYVQ QRDEYLESFC KMATRKISVI TIFGPVNNST MKIDHFQLDN EKPMRVVDDE DLVDQRLISE LRKEYGMTYN DFFMVLTDVD LRVKQYYEVP ITMKSVFDLI DTFQSRIKDM EKQKKEGIVC KEDKKQSLEN FLSRFRWRRR LLVISAPNDE DWAYSQQLSA LSGQACNFGL RHITILKLLG VGEEVGGVLE LFPINGSSVV EREDVPAHLV KDIRNYFQVS PEYFSMLLVG KDGNVKSWYP SPMWSMVIVY DLIDSMQLRR QEMAIQQSLG MRCPEDEYAG YGYHSYHQGY QDGYQDDYRH HESYHHGYPY
Bioinformatička analiza sugerira da je protein CCDC80 peroksiredoksin .[ 9]
^ a b c GRCh38: Ensembl release 89: ENSG00000091986 - Ensembl , maj 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022665 - Ensembl , maj 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Bonaldo MF, Lennon G, Soares MB (maj 1997). "Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Res . 6 (9): 791–806. doi :10.1101/gr.6.9.791 PMID 8889548 . ^ Liu Y, Monticone M, Tonachini L, Mastrogiacomo M, Marigo V, Cancedda R, Castagnola P (Aug 2004). "URB expression in human bone marrow stromal cells and during mouse development". Biochem Biophys Res Commun . 322 (2): 497–507. doi :10.1016/j.bbrc.2004.07.161 . PMID 15325258 . ^ "Entrez Gene: CCDC80 coiled-coil domain containing 80" .^ "UniProt, Q76M96" (jezik: engleski). Pristupljeno 6. 11. 2021 .^ Pawłowski K, Muszewska A, Lenart A, et al. (2010). "A widespread peroxiredoxin-like domain present in tumor suppression- and progression-implicated proteins" . BMC Genomics . 11 : 590. doi :10.1186/1471-2164-11-590 . PMC 3091736 PMID 20964819 .
Okada T, Nishizawa H, Kurata A, et al. (2008). "URB is abundantly expressed in adipose tissue and dysregulated in obesity". Biochem. Biophys. Res. Commun . 367 (2): 370–6. doi :10.1016/j.bbrc.2007.12.164 . PMID 18178152 . Cha SY, Sung YK, Im S, et al. (2005). "URB expression in human dermal papilla cells". J. Dermatol. Sci . 39 (2): 128–30. doi :10.1016/j.jdermsci.2005.05.005 . PMID 15998583 . Bommer GT, Jäger C, Dürr EM, et al. (2005). "DRO1, a gene down-regulated by oncogenes, mediates growth inhibition in colon and pancreatic cancer cells" . J. Biol. Chem . 280 (9): 7962–75. doi :10.1074/jbc.M412593200 PMID 15563452 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Aoki K, Sun YJ, Aoki S, et al. (2002). "Cloning, expression, and mapping of a gene that is upregulated in adipose tissue of mice deficient in bombesin receptor subtype-3". Biochem. Biophys. Res. Commun . 290 (4): 1282–8. doi :10.1006/bbrc.2002.6337 . PMID 11812002 .
