RRAGB

RRAGB
Identifikatori
Aliasi	RRAGB
Vanjski ID-jevi	OMIM: 300725 MGI: 3038613 HomoloGene: 48396 GeneCards: RRAGB
Lokacija gena (miš)
Hrom.	Hromosom X (miš)
Kraj	151,954,939 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• nucleotide binding; • GTP binding; • GO:0001948, GO:0016582 vezivanje za proteine; • guanyl ribonucleotide binding; • GO:0006184 GTPase activity; • protein heterodimerization activity; • GTPase binding;
Ćelijska komponenta	• citoplazma; • citosol; • lysosomal membrane; • Lizozom; • jedro; • Gtr1-Gtr2 GTPase complex;
Biološki proces	• regulation of TOR signaling; • cellular response to amino acid starvation; • cellular response to amino acid stimulus; • positive regulation of TOR signaling; • regulation of autophagy; • regulation of macroautophagy; • positive regulation of TORC1 signaling; • cellular response to leucine starvation; • cellular response to starvation;
	Izvori:Amigo / QuickGO
Ortolozi
	10325
	245670
	ENSG00000083750
	ENSMUSG00000041658
	Q5VZM2
	Q6NTA4
	NM_006064; NM_016656
	NM_001004154
	NP_006055; NP_057740; NP_001340940; NP_001340942
	NP_001004154
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Ras-srodni GTP-vezulući protein B je protein koji je kod ljudi kodiran genom RRAGB.^[4]^[5]^[6]

Ras-homologne GTPaze čine veliku porodicu pretvarača signala koji se izmjenjuju između aktiviranog, GTP-vezujućeg i inaktiviranog, GDP-vezujućeg stanja. Ti proteini predstavljaju ćelijske preklopnike kojima upravljaju faktori GTP-razmjene i faktori koji stimuliraju njihovu unutrašnju aktivnost GTPaza. Svim GTPazama superporodice Ras zajedničko je prisustvo šest konzerviranih motiva, uključenih u vezanje GTP/GDP, od kojih su tri mjesta za vezanje fosfata/magnezija (PM1-PM3) i od kojih su tri guaninska mjesta za vezanje nukleotida (G1-G3). Utvrđene su varijante transkripta koje kodiraju različite izoforme. MTORC1 reaguje na aminokiseline, interakcijom sa RAGB.^[6]

Reference

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000041658 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Schurmann A, Brauers A, Massmann S, Becker W, Joost HG (Jan 1996). "Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagB1) with remote similarity to the Ras-related GTPases". J Biol Chem. 270 (48): 28982–8. doi:10.1074/jbc.270.48.28982. PMID 7499430.
^ Hirose E, Nakashima N, Sekiguchi T, Nishimoto T (Feb 1998). "RagA is a functional homologue of S. cerevisiae Gtr1p involved in the Ran/Gsp1-GTPase pathway". J Cell Sci. 111. ( Pt 1): 11–21. PMID 9394008.
^ ^a ^b "Entrez Gene: RRAGB Ras-related GTP binding B".

Dopunska literatura

Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Tomarev SI, Wistow G, Raymond V, et al. (2003). "Gene expression profile of the human trabecular meshwork: NEIBank sequence tag analysis". Invest. Ophthalmol. Vis. Sci. 44 (6): 2588–96. doi:10.1167/iovs.02-1099. PMID 12766061.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Sekiguchi T, Hirose E, Nakashima N, et al. (2001). "Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B." J. Biol. Chem. 276 (10): 7246–57. doi:10.1074/jbc.M004389200. PMID 11073942.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000041658 - Ensembl, maj 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7499430-4] Schurmann A, Brauers A, Massmann S, Becker W, Joost HG (Jan 1996). "Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagB1) with remote similarity to the Ras-related GTPases". J Biol Chem. 270 (48): 28982–8. doi:10.1074/jbc.270.48.28982. PMID 7499430.

[pmid9394008-5] Hirose E, Nakashima N, Sekiguchi T, Nishimoto T (Feb 1998). "RagA is a functional homologue of S. cerevisiae Gtr1p involved in the Ran/Gsp1-GTPase pathway". J Cell Sci. 111. ( Pt 1): 11–21. PMID 9394008.

[entrez-6] "Entrez Gene: RRAGB Ras-related GTP binding B".

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