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TRANK1 - Wikipedia Idi na sadržaj

TRANK1

S Wikipedije, slobodne enciklopedije
TRANK1
Identifikatori
AliasiTRANK1
Vanjski ID-jeviMGI: 1341834 HomoloGene: 45845 GeneCards: TRANK1
Lokacija gena (čovjek)
Hromosom 3 (čovjek)
Hrom.Hromosom 3 (čovjek)[1]
Hromosom 3 (čovjek)
Genomska lokacija za TRANK1
Genomska lokacija za TRANK1
Bend3p22.2Početak36,826,819 bp[1]
Kraj36,945,057 bp[1]
Lokacija gena (miš)
Hromosom 9 (miš)
Hrom.Hromosom 9 (miš)[2]
Hromosom 9 (miš)
Genomska lokacija za TRANK1
Genomska lokacija za TRANK1
Bend9|9 F3Početak111,140,807 bp[2]
Kraj111,224,843 bp[2]
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_014831
NM_001329998

NM_001164659

RefSeq (bjelančevina)

NP_001316927
NP_055646

NP_001158131

Lokacija (UCSC)Chr 3: 36.83 – 36.95 MbChr 9: 111.14 – 111.22 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Protein 1 sa tetratrikopeptidnim i ankirinskim ponavljanjem jest protein koji je kod ljudi kodiran genom TRANK1 sa hromosoma 3.[5]

Aminokiselinska sekvenca

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Dužina polipeptidnog lanca je 2.925 aminokiselina, а molekulska težina Da. 336 221[6]

1020304050
MWDPRAARVPPRDLAVLLCNKSNAFFSLGKWNEAFVAAKECLQWDPTYVK
GYYRAGYSLLRLHQPYEAARMFFEGLRLVQRSQDQAPVADFLVGVFTTMS
SDSIVLQSFLPCFDHIFTTGFPTEVWQSVIEKLAKKGLWHSFLLLSAKKD
RLPRNIHVPELSLKSLFEKYVFIGLYEKMEQVPKLVQWLISIGASVETIG
PYPLHALMRLCIQARENHLFRWLMDHKPEWKGRINQKDGDGCTVLHVVAA
HSPGYLVKRQTEDVQMLLRFGADPTLLDRQSRSVVDVLKRNKNFKAIEKI
NSHLEKLATCSKDLSGFSNGDGPTSENDIFRKVLEQLVKYMNSGNRLLHK
NFLKQEVVQRFLRLLSTLQEIPPDLVCDINQDCATTVFKFLLEKQRWPEV
LLLLTRKVSGEPPLGDCLIKDCNFSDLDICTIIPHLSTWDQRKKQLLGCL
IDSGALPDGLQESQERPVVTCLKHEDFELAFLLLTKGADPRAISLTEGDT
PLHAALHIFLEIKADIGFSFLSHLLDLFWSNPTEFDYLNPNVQDSNGNTL
MHILFQKGMLKRVKKLLDLLVKFDINFNLKNKEGKDARHRIKKNDSLLLA
WNKALMENRRRSRQDSAAHLGKLSKSTAPGHTSQLKSQGSFKSVPCGATA
RTLPEGSAVPDSWETLPGTQVTRKEPGALRPCSLRDCLMQDITVLIQQVE
VDPSFPEDCLQSSEPLEAGAGKEGKKDDKPTLGAGAPDCSEVGEGHAQVG
LGALQLVPDDNRGKEGNDDQDDWSTQEIEACLQDFDNMTWEIECTSEMLK
KLSSKVMTKVIKKKIILAIQQLGNGEWTQGLQKRLKHLKGSIQLFEAKLD
KGARMLWELAIDFSPRCSENPEKIIATEQNTCAMEKSGRIYTEIIRIWDI
VLDHCKLADSIKAICNAYNRGLSCVLRKKLKGINKGQVSANMKIQKRIPR
CYVEDTEAEKGREHVNPEYFPPASAVETEYNIMKFHSFSTNMAFNILNDT
TATVEYPFRVGELEYAVIDLNPRPLEPIILIGRSGTGKTTCCLYRLWKKF
HVYWEKAEQAGSPLLAKQVWLKRRLEVEPGKESPGGEEEEEEEDEEEEDS
IEVETVESIDEQEYEACAGGAGVEPAGDGQAAEVCAPEHPHQLEHLHQIF
VTKNHVLCQEVQRNFIELSKSTKATSHYKPLDPNIHKLQDLRDENFPLFV
TSKQLLLLLDASLPKPFFLRNEDGSLKRTIIGWSAQEESTIPSWQEDEEE
AEVDGDYSEEDKAVEMRTGDSDPRVYVTFEVFKNEIWPKMTKGRTAYNPA
LIWKEIKSFLKGSFEALSCPHGRLTEEVYKKLGRKRCPNFKEDRSEIYSL
FSLYQQIRSQKGYFDEEDVLYNISRRLSKLRVLPWSIHELYGDEIQDFTQ
AELALLMKCINDPNSMFLTGDTAQSIMKGVAFRFSDLRSLFHYASRNTID
KQCAVRKPKKIHQLYQNYRSHSGILNLASGVVDLLQFYFPESFDRLPRDS
GLFDGPKPTVLESCSVSDLAILLRGNKRKTQPIEFGAHQVILVANETAKE
KIPEELGLALVLTIYEAKGLEFDDVLLYNFFTDSEAYKEWKIISSFTPTS
TDSREENRPLVEVPLDKPGSSQGRSLMVNPEMYKLLNGELKQLYTAITRA
RVNLWIFDENREKRAPAFKYFIRRDFVQVVKTDENKDFDDSMFVKTSTPA
EWIAQGDYYAKHQCWKVAAKCYQKGGAFEKEKLALAHDTALSMKSKKVSP
KEKQLEYLELAKTYLECKEPTLSLKCLSYAKEFQLSAQLCERLGKIRDAA
YFYKRSQCYKDAFRCFEQIQEFDLALKMYCQEELFEEAAIAVEKYEEMLK
TKTLPISKLSYSASQFYLEAAAKYLSANKMKEMMAVLSKLDIEDQLVFLK
SRKRLAEAADLLNREGRREEAALLMKQHGCLLEAARLTADKDFQASCLLG
AARLNVARDSDIEHTKDILREALDICYQTGQLSGIAEAHFLQGVILRDFQ
KLRDAFFKFDTLNHSAGVVEALYEAASQCEAEPEKILGLAPGGLEILLSL
VRALKRVTNNAEKEMVKSCFEFFGISQVDAKYCQIAQNDPGPILRIIFDL
DLNLREKKTKDHFLIMTDQVKLALNKHLLGRLCQITRSLLGKTYRGVCMR
FIVGLKCEDENCEHFHRPLRRCEAKCLVQSKMNLVAINGLLLEAKKVFPK
ILAEELKEIDYILSTDMYGLCKSILDVLFPKHFHQRVLSENPMACKEILK
PNYKSFRFYRFALKEYIHFLFENESARNRRESTDLWLSAMQAFLLSSNYP
EEFEKLLHQEEDNYNRELKALESEKDERGRGRGSRIKGIEGKFGMLAPNR
DDENMDKTHLCFIRLLENCIDQFYVYRNPEDYKRLFFRFMNVLIKRCKEP
LIPSIGNTVALLEFQFIHCGVVLARLWKNVILCLPKSYIALLHYWEFLFS
KKDKELGDVFSIIQEYKPKDVTRAIQDFRFHLSYLAKVLCGYENVNFNVL
LDAFSEIDYVVSGEAERTLVLCLVMLVNAEEILQPYCKPLLYRHFREIES
RLQLMSMDCPGQVPERLLKVVKRVLVAVNVKSVAEALQDLLFERDEEYLM
DCDWRWDPVHTKGSIVRGLYYEEVRLNRLLCLDPVDYFAEPECEFGQDEM
DELALEDRDHVLATILSQKQRKASIQRKLRRACLVVSLCISWRRRVGTQM
ERVREEAREPRAGNFKKADVDRTQCDLCGVKFTRGPENYFSPSKAFEGAA
SEVAVLSRAELEREECQERNSESYEQHIHLEHHQRQQVAYQKYSEFFHEK
VDPAIDEGKLVVQDIEQSVWIHSHVGSKEHSHMLQKVQEHIKRVSDMVED
LYRRKAWAGAEEAMTRLVNILILSVRDARDWLMKTETRLKKEGIVQEDDY
ENEVEDFGELRPRRRSRKCGKQRKY

Klinički značaj

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Studijom asocijacije koja obuhvata čitav genom, TRANK1 je povezan sa bipolarnim poremećajem.[7]

Reference

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000168016 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000062296 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Tetratricopeptide repeat and ankyrin repeat containing 1".
  6. ^ "UniProt, O15050" (jezik: engleski). Pristupljeno 6. 11. 2021.
  7. ^ Mühleisen TW, Leber M, Schulze TG, Strohmaier J, Degenhardt F, Treutlein J, et al. (mart 2014). "Genome-wide association study reveals two new risk loci for bipolar disorder". Nature Communications. 5: 3339. Bibcode:2014NatCo...5.3339M. doi:10.1038/ncomms4339. PMID 24618891.

Dopunska literatura

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