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Protein 1 sa tetratrikopeptidnim i ankirinskim ponavljanjem jest protein koji je kod ljudi kodiran genom TRANK1 sa hromosoma 3.[5]
Dužina polipeptidnog lanca je 2.925 aminokiselina, а molekulska težina Da. 336 221[6]
| 10 | | 20 | | 30 | | 40 | | 50 |
|---|
| MWDPRAARVP | | PRDLAVLLCN | | KSNAFFSLGK | | WNEAFVAAKE | | CLQWDPTYVK |
| GYYRAGYSLL | | RLHQPYEAAR | | MFFEGLRLVQ | | RSQDQAPVAD | | FLVGVFTTMS |
| SDSIVLQSFL | | PCFDHIFTTG | | FPTEVWQSVI | | EKLAKKGLWH | | SFLLLSAKKD |
| RLPRNIHVPE | | LSLKSLFEKY | | VFIGLYEKME | | QVPKLVQWLI | | SIGASVETIG |
| PYPLHALMRL | | CIQARENHLF | | RWLMDHKPEW | | KGRINQKDGD | | GCTVLHVVAA |
| HSPGYLVKRQ | | TEDVQMLLRF | | GADPTLLDRQ | | SRSVVDVLKR | | NKNFKAIEKI |
| NSHLEKLATC | | SKDLSGFSNG | | DGPTSENDIF | | RKVLEQLVKY | | MNSGNRLLHK |
| NFLKQEVVQR | | FLRLLSTLQE | | IPPDLVCDIN | | QDCATTVFKF | | LLEKQRWPEV |
| LLLLTRKVSG | | EPPLGDCLIK | | DCNFSDLDIC | | TIIPHLSTWD | | QRKKQLLGCL |
| IDSGALPDGL | | QESQERPVVT | | CLKHEDFELA | | FLLLTKGADP | | RAISLTEGDT |
| PLHAALHIFL | | EIKADIGFSF | | LSHLLDLFWS | | NPTEFDYLNP | | NVQDSNGNTL |
| MHILFQKGML | | KRVKKLLDLL | | VKFDINFNLK | | NKEGKDARHR | | IKKNDSLLLA |
| WNKALMENRR | | RSRQDSAAHL | | GKLSKSTAPG | | HTSQLKSQGS | | FKSVPCGATA |
| RTLPEGSAVP | | DSWETLPGTQ | | VTRKEPGALR | | PCSLRDCLMQ | | DITVLIQQVE |
| VDPSFPEDCL | | QSSEPLEAGA | | GKEGKKDDKP | | TLGAGAPDCS | | EVGEGHAQVG |
| LGALQLVPDD | | NRGKEGNDDQ | | DDWSTQEIEA | | CLQDFDNMTW | | EIECTSEMLK |
| KLSSKVMTKV | | IKKKIILAIQ | | QLGNGEWTQG | | LQKRLKHLKG | | SIQLFEAKLD |
| KGARMLWELA | | IDFSPRCSEN | | PEKIIATEQN | | TCAMEKSGRI | | YTEIIRIWDI |
| VLDHCKLADS | | IKAICNAYNR | | GLSCVLRKKL | | KGINKGQVSA | | NMKIQKRIPR |
| CYVEDTEAEK | | GREHVNPEYF | | PPASAVETEY | | NIMKFHSFST | | NMAFNILNDT |
| TATVEYPFRV | | GELEYAVIDL | | NPRPLEPIIL | | IGRSGTGKTT | | CCLYRLWKKF |
| HVYWEKAEQA | | GSPLLAKQVW | | LKRRLEVEPG | | KESPGGEEEE | | EEEDEEEEDS |
| IEVETVESID | | EQEYEACAGG | | AGVEPAGDGQ | | AAEVCAPEHP | | HQLEHLHQIF |
| VTKNHVLCQE | | VQRNFIELSK | | STKATSHYKP | | LDPNIHKLQD | | LRDENFPLFV |
| TSKQLLLLLD | | ASLPKPFFLR | | NEDGSLKRTI | | IGWSAQEEST | | IPSWQEDEEE |
| AEVDGDYSEE | | DKAVEMRTGD | | SDPRVYVTFE | | VFKNEIWPKM | | TKGRTAYNPA |
| LIWKEIKSFL | | KGSFEALSCP | | HGRLTEEVYK | | KLGRKRCPNF | | KEDRSEIYSL |
| FSLYQQIRSQ | | KGYFDEEDVL | | YNISRRLSKL | | RVLPWSIHEL | | YGDEIQDFTQ |
| AELALLMKCI | | NDPNSMFLTG | | DTAQSIMKGV | | AFRFSDLRSL | | FHYASRNTID |
| KQCAVRKPKK | | IHQLYQNYRS | | HSGILNLASG | | VVDLLQFYFP | | ESFDRLPRDS |
| GLFDGPKPTV | | LESCSVSDLA | | ILLRGNKRKT | | QPIEFGAHQV | | ILVANETAKE |
| KIPEELGLAL | | VLTIYEAKGL | | EFDDVLLYNF | | FTDSEAYKEW | | KIISSFTPTS |
| TDSREENRPL | | VEVPLDKPGS | | SQGRSLMVNP | | EMYKLLNGEL | | KQLYTAITRA |
| RVNLWIFDEN | | REKRAPAFKY | | FIRRDFVQVV | | KTDENKDFDD | | SMFVKTSTPA |
| EWIAQGDYYA | | KHQCWKVAAK | | CYQKGGAFEK | | EKLALAHDTA | | LSMKSKKVSP |
| KEKQLEYLEL | | AKTYLECKEP | | TLSLKCLSYA | | KEFQLSAQLC | | ERLGKIRDAA |
| YFYKRSQCYK | | DAFRCFEQIQ | | EFDLALKMYC | | QEELFEEAAI | | AVEKYEEMLK |
| TKTLPISKLS | | YSASQFYLEA | | AAKYLSANKM | | KEMMAVLSKL | | DIEDQLVFLK |
| SRKRLAEAAD | | LLNREGRREE | | AALLMKQHGC | | LLEAARLTAD | | KDFQASCLLG |
| AARLNVARDS | | DIEHTKDILR | | EALDICYQTG | | QLSGIAEAHF | | LQGVILRDFQ |
| KLRDAFFKFD | | TLNHSAGVVE | | ALYEAASQCE | | AEPEKILGLA | | PGGLEILLSL |
| VRALKRVTNN | | AEKEMVKSCF | | EFFGISQVDA | | KYCQIAQNDP | | GPILRIIFDL |
| DLNLREKKTK | | DHFLIMTDQV | | KLALNKHLLG | | RLCQITRSLL | | GKTYRGVCMR |
| FIVGLKCEDE | | NCEHFHRPLR | | RCEAKCLVQS | | KMNLVAINGL | | LLEAKKVFPK |
| ILAEELKEID | | YILSTDMYGL | | CKSILDVLFP | | KHFHQRVLSE | | NPMACKEILK |
| PNYKSFRFYR | | FALKEYIHFL | | FENESARNRR | | ESTDLWLSAM | | QAFLLSSNYP |
| EEFEKLLHQE | | EDNYNRELKA | | LESEKDERGR | | GRGSRIKGIE | | GKFGMLAPNR |
| DDENMDKTHL | | CFIRLLENCI | | DQFYVYRNPE | | DYKRLFFRFM | | NVLIKRCKEP |
| LIPSIGNTVA | | LLEFQFIHCG | | VVLARLWKNV | | ILCLPKSYIA | | LLHYWEFLFS |
| KKDKELGDVF | | SIIQEYKPKD | | VTRAIQDFRF | | HLSYLAKVLC | | GYENVNFNVL |
| LDAFSEIDYV | | VSGEAERTLV | | LCLVMLVNAE | | EILQPYCKPL | | LYRHFREIES |
| RLQLMSMDCP | | GQVPERLLKV | | VKRVLVAVNV | | KSVAEALQDL | | LFERDEEYLM |
| DCDWRWDPVH | | TKGSIVRGLY | | YEEVRLNRLL | | CLDPVDYFAE | | PECEFGQDEM |
| DELALEDRDH | | VLATILSQKQ | | RKASIQRKLR | | RACLVVSLCI | | SWRRRVGTQM |
| ERVREEAREP | | RAGNFKKADV | | DRTQCDLCGV | | KFTRGPENYF | | SPSKAFEGAA |
| SEVAVLSRAE | | LEREECQERN | | SESYEQHIHL | | EHHQRQQVAY | | QKYSEFFHEK |
| VDPAIDEGKL | | VVQDIEQSVW | | IHSHVGSKEH | | SHMLQKVQEH | | IKRVSDMVED |
| LYRRKAWAGA | | EEAMTRLVNI | | LILSVRDARD | | WLMKTETRLK | | KEGIVQEDDY |
| ENEVEDFGEL | | RPRRRSRKCG | | KQRKY |
Studijom asocijacije koja obuhvata čitav genom, TRANK1 je povezan sa bipolarnim poremećajem.[7]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000168016 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000062296 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Tetratricopeptide repeat and ankyrin repeat containing 1".
- ^ "UniProt, O15050" (jezik: engleski). Pristupljeno 6. 11. 2021.
- ^
Mühleisen TW, Leber M, Schulze TG, Strohmaier J, Degenhardt F, Treutlein J, et al. (mart 2014). "Genome-wide association study reveals two new risk loci for bipolar disorder". Nature Communications. 5: 3339. Bibcode:2014NatCo...5.3339M. doi:10.1038/ncomms4339. PMID 24618891.
- Goes FS, Hamshere ML, Seifuddin F, Pirooznia M, Belmonte-Mahon P, Breuer R, et al. (oktobar 2012). "Genome-wide association of mood-incongruent psychotic bipolar disorder". Translational Psychiatry. 2 (10): e180. doi:10.1038/tp.2012.106. PMC 3565814. PMID 23092984.
- Chen DT, Jiang X, Akula N, Shugart YY, Wendland JR, Steele CJ, et al. (februar 2013). "Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder". Molecular Psychiatry. 18 (2): 195–205. doi:10.1038/mp.2011.157. PMID 22182935.
