PLCG2

PLCG2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2K2J, 2W2W, 2W2X
Dynodwyr
Cyfenwau	PLCG2, APLAID, FCAS3, PLC-IV, PLC-gamma-2, phospholipase C gamma 2
Dynodwyr allanol	OMIM: 600220 HomoloGene: 55671 GeneCards: PLCG2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • signal transducer activity • GO:0001948, GO:0016582 protein binding • phosphoric diester hydrolase activity • phospholipase C activity • hydrolase activity • phosphatidylinositol phospholipase C activity • phosphotyrosine residue binding Cydrannau o'r gell • cytosol • Cellbilen • extracellular exosome Prosesau biolegol • B cell receptor signaling pathway • release of sequestered calcium ion into cytosol • GO:0007243 intracellular signal transduction • inositol trisphosphate biosynthetic process • Fc-gamma receptor signaling pathway involved in phagocytosis • positive regulation of receptor internalization • lipid metabolism • stimulatory C-type lectin receptor signaling pathway • inositol phosphate metabolic process • Wnt signaling pathway • platelet activation • Fc-epsilon receptor signaling pathway • lipid catabolic process • follicular B cell differentiation • response to lipopolysaccharide • phospholipid catabolic process • regulation of gene expression • phosphatidylinositol biosynthetic process • negative regulation of programmed cell death • B cell differentiation • T cell receptor signaling pathway • activation of store-operated calcium channel activity • positive regulation of type I interferon production • calcium-mediated signaling • GO:0072468 signal transduction • phosphatidylinositol-mediated signaling Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5336	n/a
Ensembl	ENSG00000197943	n/a
UniProt	P16885	n/a
RefSeq (mRNA)	NM_002661	n/a
RefSeq (protein)	NP_002652	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PLCG2 yw PLCG2 a elwir hefyd yn Phospholipase C gamma 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 16, band 16q23.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PLCG2.

• FCAS3
• APLAID
• PLC-IV
• PLC-gamma-2

Llyfryddiaeth

• "The autoinhibitory C-terminal SH2 domain of phospholipase C-γ2 stabilizes B cell receptor signalosome assembly. ". Sci Signal. 2014. PMID 25227611.
• "Expression and pro-survival function of phospholipase Cγ2 in diffuse large B-cell lymphoma. ". Leuk Lymphoma. 2015. PMID 25012946.
• "Ocular Manifestations of Inherited Phospholipase-Cγ2-Associated Antibody Deficiency and Immune Dysregulation. ". Cornea. 2016. PMID 27442322.
• "Cool-temperature-mediated activation of phospholipase C-γ2 in the human hereditary disease PLAID. ". Cell Signal. 2016. PMID 27196803.
• "Hypermorphic mutation of phospholipase C, γ2 acquired in ibrutinib-resistant CLL confers BTK independency upon B-cell receptor activation.". Blood. 2015. PMID 25972157.