ATP2B4 Dynodwyr Cyfenwau ATP2B4 Dynodwyr allanol OMIM: 108732 HomoloGene: 48034 GeneCards: ATP2B4 Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • PDZ domain binding • sodium channel regulator activity • nitric-oxide synthase binding • scaffold protein binding • metal ion binding • calmodulin binding • nitric-oxide synthase inhibitor activity • GO:0001948, GO:0016582 protein binding • protein phosphatase 2B binding • ATP binding • hydrolase activity • P-type calcium transporter activity • protein kinase binding Cydrannau o'r gell • integral component of membrane • cell projection • bilen • intracellular membrane-bounded organelle • T-tubule • Cellbilen • integral component of plasma membrane • sperm flagellum • sperm principal piece • basolateral plasma membrane • Z discdkac • caveola • neuron projection • sarcolemma • cilium • motile cilium • GO:0009327 protein-containing complex • glutamatergic synapse • integral component of presynaptic active zone membrane Prosesau biolegol • negative regulation of nitric oxide mediated signal transduction • flagellated sperm motility • regulation of cardiac conduction • negative regulation of nitric-oxide synthase activity • negative regulation of calcineurin-NFAT signaling cascade • negative regulation of citrulline biosynthetic process • negative regulation of peptidyl-cysteine S-nitrosylation • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • calcium ion import across plasma membrane • response to hydrostatic pressure • cellular calcium ion homeostasis • cludo ïon • positive regulation of peptidyl-serine phosphorylation • cellular response to epinephrine stimulus • cludo transmembrane rhwng ïonau • negative regulation of nitric oxide biosynthetic process • calcium ion transmembrane transport • GO:0060401 calcium ion transmembrane import into cytosol • spermatogenesis • positive regulation of cAMP-dependent protein kinase activity • regulation of cell cycle G1/S phase transition • regulation of sodium ion transmembrane transport • calcium ion export • hippocampus development • GO:0100045 negative regulation of arginine catabolic process • neural retina development • negative regulation of the force of heart contraction • calcium ion transport • negative regulation of cardiac muscle hypertrophy in response to stress • GO:0015915 transport • regulation of cytosolic calcium ion concentration • negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process • urinary bladder smooth muscle contraction • cellular response to acetylcholine Sources:Amigo / QuickGO
Orthologau Species Bod dynol Llygoden Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Lleoliad (UCSC) n/a n/a PubMed search[ 1] n/a Wicidata
Protein sy'n cael ei godio yn y corff dynol gan y genyn ATP2B4 yw ATP2B4 a elwir hefyd yn ATPase plasma membrane Ca2+ transporting 4 (Saesneg). Segment o DNA yw'r genyn , sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1q32.1.[ 2]
Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ATP2B4.
MXRA1
PMCA4
ATP2B2
PMCA4b
PMCA4x
"Sequence to Medical Phenotypes: A Framework for Interpretation of Human Whole Genome DNA Sequence Data. ". PLoS Genet . 2015. PMID 26448358 . "PMCA4 (ATP2B4) mutation in familial spastic paraplegia causes delay in intracellular calcium extrusion. ". Brain Behav . 2015. PMID 25798335 . "Substrate trajectory through phospholipid-transporting P4-ATPases. ". Biochem Soc Trans . 2014. PMID 25233416 . "PMCA4 (ATP2B4) mutation in familial spastic paraplegia. ". PLoS One . 2014. PMID 25119969 . "A C-terminal di-leucine motif controls plasma membrane expression of PMCA4b. ". Biochim Biophys Acta . 2013. PMID 23830917 . 
