EPHA2

EPHA2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1MQB, 2E8N, 2K9Y, 2KSO, 2X10, 2X11, 3C8X, 3CZU, 3FL7, 3HEI, 3HPN, 3KKA, 3MBW, 3MX0, 3SKJ, 4P2K, 4PDO, 4TRL, 5EK7
Dynodwyr
Cyfenwau	EPHA2, Epha2, AW545284, Eck, Myk2, Sek-2, Sek2, ARCC2, CTPA, CTPP1, CTRCT6, EPH receptor A2, ECK
Dynodwyr allanol	OMIM: 176946 HomoloGene: 20929 GeneCards: EPHA2
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• nucleotide binding; • protein kinase activity; • transferase activity; • kinase activity; • GO:0001948, GO:0016582 protein binding; • protein tyrosine kinase activity; • ATP binding; • ephrin receptor activity; • transmembrane receptor protein tyrosine kinase activity; • cadherin binding; • virus receptor activity; • transmembrane-ephrin receptor activity;
Cydrannau o'r gell	• integral component of membrane; • cell projection; • bilen; • ruffle membrane; • cell junction; • lamellipodium membrane; • leading edge membrane; • focal adhesion; • integral component of plasma membrane; • intracellular anatomical structure; • Cellbilen; • lamellipodium; • cell surface; • neuron projection; • receptor complex; • tight junctions;
Prosesau biolegol	• regulation of lamellipodium assembly; • skeletal system development; • negative regulation of protein kinase B signaling; • cell differentiation; • regulation of cell adhesion mediated by integrin; • protein kinase B signaling; • GO:0032861, GO:0032862, GO:0032856 activation of GTPase activity; • phosphorylation; • transmembrane receptor protein tyrosine kinase signaling pathway; • keratinocyte differentiation; • vasculogenesis; • multicellular organism development; • protein phosphorylation; • cell adhesion; • blood vessel development; • notochord morphogenesis; • notochord cell development; • angiogenesis; • intrinsic apoptotic signaling pathway in response to DNA damage; • neural tube development; • neuron differentiation; • notochord; • regulation of ERK1 and ERK2 cascade; • cell chemotaxis; • post-anal tail morphogenesis; • axial mesoderm formation; • response to growth factor; • GO:0022415 viral process; • cell migration; • GO:0097285 apoptotic process; • peptidyl-tyrosine phosphorylation; • osteoclast differentiation; • osteoblast differentiation; • regulation of angiogenesis; • regulation of blood vessel endothelial cell migration; • ephrin receptor signaling pathway; • lens fiber cell morphogenesis; • mammary gland epithelial cell proliferation; • bone remodeling; • branching involved in mammary gland duct morphogenesis; • GO:0032697 negative regulation of cytokine production; • GO:0051637 defense response to Gram-positive bacterium; • negative regulation of lymphangiogenesis; • blood vessel endothelial cell proliferation involved in sprouting angiogenesis; • pericyte cell differentiation; • negative regulation of angiogenesis; • inflammatory response; • negative regulation of chemokine production; • blood vessel morphogenesis; • cAMP metabolic process; • cell motility; • viral entry into host cell; • positive regulation of protein localization to plasma membrane; • axon guidance; • protein localization to plasma membrane; • positive regulation of bicellular tight junction assembly;
	Sources:Amigo / QuickGO
Orthologau
	1969
	n/a
	ENSG00000142627
	n/a
	P29317
	n/a
	NM_004431; NM_001329090
	n/a
	NP_001316019; NP_004422
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn EPHA2 yw EPHA2 a elwir hefyd yn EPH receptor A2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1p36.13.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn EPHA2.

ECK
CTPA
ARCC2
CTPP1
CTRCT6

Llyfryddiaeth

"The SAM domain inhibits EphA2 interactions in the plasma membrane. ". Biochim Biophys Acta. 2017. PMID 27776928.
"Silencing Receptor EphA2 Enhanced Sensitivity to Lipoplatinâ„¢ in Lung Tumor and MPM Cells. ". Cancer Invest. 2016. PMID 27438907.
"Ionizing radiation induces EphA2 S897 phosphorylation in a MEK/ERK/RSK-dependent manner. ". Int J Radiat Biol. 2017. PMID 28705041.
"Structural investigation of a C-terminal EphA2 receptor mutant: Does mutation affect the structure and interaction properties of the Sam domain?". Biochim Biophys Acta. 2017. PMID 28602916.
"Targeting EphA2 impairs cell cycle progression and growth of basal-like/triple-negative breast cancers.". Oncogene. 2017. PMID 28581527.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] EPHA2 - Cronfa NCBI

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[2]