GRIN2B

GRIN2B
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 5EWM, 5EWL, 5EWJ
Dynodwyr
Cyfenwau	GRIN2B, GluN2B, MRD6, NMDAR2B, NR2B, hNR3, EIEE27, glutamate ionotropic receptor NMDA type subunit 2B, NR3, DEE27
Dynodwyr allanol	OMIM: 138252 HomoloGene: 646 GeneCards: GRIN2B
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • zinc ion binding • glycine binding • metal ion binding • ion channel activity • GO:0001948, GO:0016582 protein binding • ionotropic glutamate receptor activity • extracellularly glutamate-gated ion channel activity • NMDA glutamate receptor activity • glutamate binding • glutamate-gated calcium ion channel activity • amyloid-beta binding • signaling receptor activity Cydrannau o'r gell • integral component of membrane • postsynaptic membrane • bilen • synapse • NMDA selective glutamate receptor complex • cell surface • cell junction • neuron projection • intracellular anatomical structure • integral component of plasma membrane • GO:0097483, GO:0097481 postsynaptic density • Cellbilen • cytoplasm • synaptic membrane • postsynaptic density membrane Prosesau biolegol • glutamate receptor signaling pathway • ephrin receptor signaling pathway • cludo ïon • MAPK cascade • learning or memory • response to ethanol • chemical synaptic transmission • ionotropic glutamate receptor signaling pathway • excitatory postsynaptic potential • regulation of ion transmembrane transport • GO:0015915 transport • calcium-mediated signaling • protein heterotetramerization • regulation of molecular function • GO:0060401 calcium ion transmembrane import into cytosol • multicellular organism development • brain development • regulation of synaptic plasticity • long-term potentiation • excitatory chemical synaptic transmission • positive regulation of neuron death • negative regulation of dendritic spine maintenance • positive regulation of cysteine-type endopeptidase activity • regulation of NMDA receptor activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2904	n/a
Ensembl	ENSG00000273079	n/a
UniProt	Q13224	n/a
RefSeq (mRNA)	NM_000834	n/a
RefSeq (protein)	NP_000825	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GRIN2B yw GRIN2B a elwir hefyd yn Glutamate ionotropic receptor NMDA type subunit 2B (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 12, band 12p13.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GRIN2B.

• NR3
• MRD6
• NR2B
• hNR3
• EIEE27
• GluN2B
• NMDAR2B

Llyfryddiaeth

• "NMDA receptors: linking physiological output to biophysical operation. ". Nat Rev Neurosci. 2017. PMID 28303017.
• "Human GRIN2B variants in neurodevelopmental disorders. ". J Pharmacol Sci. 2016. PMID 27818011.
• "Further evidence for GRIN2B mutation as the cause of severe epileptic encephalopathy. ". Am J Med Genet A. 2016. PMID 27605359.
• "A study of single nucleotide polymorphisms of GRIN2B in schizophrenia from Chinese Han population. ". Neurosci Lett. 2016. PMID 27453061.
• "Association of GRIN2B gene polymorphism and Obsessive Compulsive disorder and symptom dimensions: A pilot study.". Psychiatry Res. 2016. PMID 27394963.