MKL1

MRTFA
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2KVU, 2KW9
Dynodwyr
Cyfenwau	MRTFA, BSAC, MAL, MRTF-A, megakaryoblastic leukemia (translocation) 1, MKL, MKL1, myocardin related transcription factor A
Dynodwyr allanol	OMIM: 606078 HomoloGene: 32487 GeneCards: MRTFA
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001105 transcription coactivator activity • actin monomer binding • leucine zipper domain binding • GO:0001948, GO:0016582 protein binding • actin binding Cydrannau o'r gell • cytoplasm • nucleoplasm • cnewyllyn cell • cytosol Prosesau biolegol • GO:0009373 regulation of transcription, DNA-templated • smooth muscle cell differentiation • transcription, DNA-templated • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • transcription by RNA polymerase II • actin cytoskeleton organization Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	57591	n/a
Ensembl	ENSG00000196588	n/a
UniProt	Q969V6	n/a
RefSeq (mRNA)	NM_001282660 NM_001282661 NM_001282662 NM_020831 NM_001318139	n/a
RefSeq (protein)	NP_001269589 NP_001269590 NP_001269591 NP_001305068 NP_065882	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MKL1 yw MKL1 a elwir hefyd yn Megakaryoblastic leukemia (translocation) 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 22, band 22q13.1-q13.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MKL1.

• MAL
• MKL
• BSAC
• MRTF-A

Llyfryddiaeth

• "Mechanism of irradiation-induced mammary cancer metastasis: A role for SAP-dependent Mkl1 signaling. ". Mol Oncol. 2015. PMID 25999144.
• "Activation of the MKL1/actin signaling pathway induces hormonal escape in estrogen-responsive breast cancer cell lines. ". Mol Cell Endocrinol. 2014. PMID 24721635.
• "Regulation of microRNA expression in vascular smooth muscle by MRTF-A and actin polymerization. ". Biochim Biophys Acta. 2017. PMID 27939432.
• "Association between MKL1 rs6001946 and schizophrenia in a Han Chinese population. ". Neurosci Lett. 2016. PMID 27507698.
• "Immunodeficiency and severe susceptibility to bacterial infection associated with a loss-of-function homozygous mutation of MKL1.". Blood. 2015. PMID 26224645.