YARS

YARS1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1N3L, 1NTG, 1Q11, 4Q93, 4QBT
Dynodwyr
Cyfenwau	YARS1, CMTDIC, TYRRS, YRS, YTS, tyrosyl-tRNA synthetase, tyrosyl-tRNA synthetase 1, YARS, IMNEPD2
Dynodwyr allanol	OMIM: 603623 HomoloGene: 2730 GeneCards: YARS1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • aminoacyl-tRNA ligase activity • nucleotide binding • signal transducer activity • ligase activity • GO:0001948, GO:0016582 protein binding • interleukin-8 receptor binding • ATP binding • tyrosine-tRNA ligase activity • tRNA binding • RNA binding Cydrannau o'r gell • extracellular space • cytoplasm • nuclear body • cytosol • aminoacyl-tRNA synthetase multienzyme complex • methionyl glutamyl tRNA synthetase complex Prosesau biolegol • tyrosyl-tRNA aminoacylation • protein biosynthesis • GO:0097285 apoptotic process • GO:0072468 signal transduction • tRNA aminoacylation for protein translation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	8565	n/a
Ensembl	ENSG00000134684	n/a
UniProt	P54577	n/a
RefSeq (mRNA)	NM_003680	n/a
RefSeq (protein)	NP_003671	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn YARS yw YARS a elwir hefyd yn Tyrosyl-tRNA synthetase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1p35.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn YARS.

• YRS
• YTS
• TYRRS
• CMTDIC

Llyfryddiaeth

• "Alternative splicing creates two new architectures for human tyrosyl-tRNA synthetase. ". Nucleic Acids Res. 2016. PMID 26773056.
• "Recombinant human tyrosyl-tRNA synthetase, a novel thrombopoietic agent. ". Eur J Pharmacol. 2014. PMID 24907514.
• "Alternative stable conformation capable of protein misinteraction links tRNA synthetase to peripheral neuropathy. ". Nucleic Acids Res. 2017. PMID 28531329.
• "A novel multisystem disease associated with recessive mutations in the tyrosyl-tRNA synthetase (YARS) gene. ". Am J Med Genet A. 2017. PMID 27633801.
• "[COMPUTATIONAL MODELING OF MOLECULAR DYNAMICS OF G41R MUTANT FORM OF HUMAN TYROSYL-tRNA SYNTHETASE, ASSOSIATED WITH CHARCOT-MARIE-TOOTH NEUROPATHY].". Ukr Biochem J. 2015. PMID 27025069.