YES1

YES1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2HDA
Dynodwyr
Cyfenwau	YES1, HsT441, P61-YES, Yes, c-yes, YES proto-oncogene 1, Src family tyrosine kinase
Dynodwyr allanol	OMIM: 164880 HomoloGene: 55900 GeneCards: YES1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • protein kinase activity • transmembrane transporter binding • epidermal growth factor receptor binding • non-membrane spanning protein tyrosine kinase activity • kinase activity • GO:0001948, GO:0016582 protein binding • enzyme binding • protein tyrosine kinase activity • signaling receptor binding • ATP binding • phosphotyrosine residue binding Cydrannau o'r gell • Golgi apparatus • bilen • focal adhesion • extrinsic component of cytoplasmic side of plasma membrane • Cellbilen • microtubule organizing center • Microffilament • extracellular exosome • Cytosgerbwd • cytoplasm • cytosol • glutamatergic synapse • postsynaptic specialization, intracellular component Prosesau biolegol • cellular response to transforming growth factor beta stimulus • cellular response to retinoic acid • cell differentiation • Fc-gamma receptor signaling pathway involved in phagocytosis • phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • ephrin receptor signaling pathway • T cell costimulation • cellular response to platelet-derived growth factor stimulus • protein phosphorylation • regulation of vascular permeability • regulation of cell population proliferation • positive regulation of peptidyl-tyrosine phosphorylation • peptidyl-tyrosine autophosphorylation • protein autophosphorylation • leukocyte migration • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • innate immune response • cell migration • regulation of glucose transmembrane transport Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7525	n/a
Ensembl	ENSG00000176105	n/a
UniProt	P07947	n/a
RefSeq (mRNA)	NM_005433	n/a
RefSeq (protein)	NP_005424	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn YES1 yw YES1 a elwir hefyd yn YES proto-oncogene 1, Src family tyrosine kinase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 18, band 18p11.32.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn YES1.

• Yes
• c-yes
• HsT441
• P61-YES

Llyfryddiaeth

• "Functional activation of Src family kinase yes protein is essential for the enhanced malignant properties of human melanoma cells expressing ganglioside GD3. ". J Biol Chem. 2011. PMID 21454696.
• "Differential expression of Yes-associated protein is correlated with expression of cell cycle markers and pathologic TNM staging in non-small-cell lung carcinoma. ". Hum Pathol. 2011. PMID 21190720.
• "c-Yes enhances tumor migration and invasion via PI3K/AKT pathway in epithelial ovarian cancer. ". Exp Mol Pathol. 2016. PMID 27289010.
• "IGF-1R Inhibition Activates a YES/SFK Bypass Resistance Pathway: Rational Basis for Co-Targeting IGF-1R and Yes/SFK Kinase in Rhabdomyosarcoma. ". Neoplasia. 2015. PMID 25925378.
• "Yes is a central mediator of cell growth in malignant mesothelioma cells.". Oncol Rep. 2012. PMID 22948717.