ZEB2

ZEB2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2DA7
Dynodwyr
Cyfenwau	ZEB2, HSPC082, SIP-1, SIP1, SMADIP1, ZFHX1B, zinc finger E-box binding homeobox 2
Dynodwyr allanol	OMIM: 605802 HomoloGene: 8868 GeneCards: ZEB2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • phosphatase regulator activity • metal ion binding • GO:0001948, GO:0016582 protein binding • nucleic acid binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • R-SMAD binding • sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • cnewyllyn cell • nucleolus • cytosol Prosesau biolegol • GO:0009373 regulation of transcription, DNA-templated • nervous system development • transcription, DNA-templated • positive regulation of melanin biosynthetic process • GO:1901227 negative regulation of transcription by RNA polymerase II • neural crest cell migration • somitogenesis • neural tube closure • transcription by RNA polymerase II • central nervous system development • corpus callosum morphogenesis • hippocampus development • cell proliferation in forebrain • corticospinal tract morphogenesis • positive regulation of Wnt signaling pathway • positive regulation of JUN kinase activity • positive regulation of melanocyte differentiation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • developmental pigmentation • embryonic morphogenesis • collateral sprouting • positive regulation of axonogenesis • mammillary axonal complex development • melanocyte migration • positive regulation of lens fiber cell differentiation • regulation of melanosome organization Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	9839	n/a
Ensembl	ENSG00000169554	n/a
UniProt	O60315	n/a
RefSeq (mRNA)	NM_001171653 NM_014795	n/a
RefSeq (protein)	NP_001165124 NP_055610	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ZEB2 yw ZEB2 a elwir hefyd yn Zinc finger E-box-binding homeobox 2 a Zinc finger E-box binding homeobox 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2q22.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ZEB2.

• SIP1
• SIP-1
• ZFHX1B
• HSPC082
• SMADIP1

Llyfryddiaeth

• "Short stretches of rare codons regulate translation of the transcription factor ZEB2 in cancer cells. ". Oncogene. 2017. PMID 28783176.
• "Novel Zeb2 gene variation in the Mowat Wilson syndrome (MWS). ". J Pediatr Surg. 2016. PMID 26852091.
• "A new risk locus in the ZEB2 gene for schizophrenia in the Han Chinese population. ". Prog Neuropsychopharmacol Biol Psychiatry. 2016. PMID 26654950.
• "MicroRNA-138 Regulates Metastatic Potential of Bladder Cancer Through ZEB2. ". Cell Physiol Biochem. 2015. PMID 26646296.
• "ZEB2/SIP1 as novel prognostic indicator in eyelid sebaceous gland carcinoma.". Hum Pathol. 2015. PMID 26220160.