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Effectiveness and safety of tocilizumab in patients with systemic sclerosis : a propensity score matched controlled observational study of the EUSTAR cohort / Kuster, Simon (Universitätsspital Zürich (Suïssa)) ; Jordan, Suzana (Universitätsspital Zürich (Suïssa)) ; Elhai, Muriel (Université Paris Cité) ; Held, Ulrike (Universitätsspital Zürich (Suïssa)) ; Steigmiller, Klaus (Department of Biostatistics at Epidemiology. Biostatistics and Prevention Institute. University of Zurich) ; Bruni, Cosimo (Department of Experimental and Clinical Medicine. Division of Rheumatology. University of Florence) ; University Hospital Polyclinic of Bari ; Vettori, Serena (University of Campania Luigi Vanvitelli) ; Siegert, Elise (Berlin Institute of Health at Charité) ; Rednic, Simona (Clinica Reumatologie. University of Medicine and Pharmacy) ; Codullo, Veronica (Fondazione IRCCS Policlinico San Matteo (Pavia, Itàlia)) ; Airò, Paolo (Spedali Civili di Brescia) ; Braun-Moscovici, Yolanda (B. Shine Department of Rheumatology. Rambam Health Care Campus and Technion) ; Hunzelmann, Nicolas (University of Cologne) ; Joao Salvador, Maria (Centro Hospitalar e Universitário de Coimbra (Coimbra, Portugal)) ; Riccieri, Valeria (Sapienza University of Rome) ; Gheorghiu, Ana-Maria (Dr. Carol Davila University of Medicine and Pharmacy (Bucarest, Romania)) ; Alegre-Sancho, Juan José (Hospital Universitari Doctor Peset (València)) ; Romanowska-Prochnicka, Katarzyna (Department of Connective Tissues Diseases. Institute of Rheumatology) ; Castellvi, Ivan (Institut d'Investigació Biomèdica Sant Pau) ; Kötter, Ina (University Hospital Hamburg-Eppendorf. Division of Rheumatology and Systemic Inflammatory Diseases) ; Truchetet, Marie-Elise (Hospital General Universitario Gregorio Marañón) ; López-Longo, F.J. (Hopital Pellegrin) ; Novikov, Pavel I. (Hopital Pellegrin) ; Giollo, Alessandro (University of Verona) ; Shirai, Yuichiro (Nippon Medical School) ; Belloli, Laura (Rheumatology Unit. Asst Grande Ospedale Metropolitano Niguarda) ; Zanatta, Elisabetta (Università degli Studi di Padova) ; Hachulla, Eric (Université de Lille) ; Smith, Vanessa (Vib Inflammation Research Centre (IRC)) ; Denton, Christopher P. (University College London Medical School) ; Ionescu, Ruxandra M. (Dr. Carol Davila University of Medicine and Pharmacy (Bucarest, Romania)) ; Schmeiser, Tim (Krankenhaus St. Josef) ; Distler, Joerg H.W. (Erlangen University Hospital) ; Gabrielli, Armando (Università Politecnica Delle Marche) ; Hoffmann-Vold, Anna-Maria (Rikshospitalet University Hospital Oslo) ; Kuwana, Masataka (Nippon Medical School Graduate School of Medicine) ; Allanore, Yannick (Université Paris Cité) ; Distler, Oliver (Universitätsspital Zürich (Suïssa))
Objectives Tocilizumab showed trends for improving skin fibrosis and prevented progression of lung fibrosis in systemic sclerosis (SSc) in randomised controlled clinical trials. We aimed to assess safety and effectiveness of tocilizumab in a real-life setting using the European Scleroderma Trial and Research (EUSTAR) database. [...]
2022 - DOI (Digital Object Identifier)

10.1136/rmdopen-2022-002477
RMD Open, Vol. 8 Núm. 2 (march 2022) , p. e002477

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