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1.
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33 p, 20.4 MB |
Hyaluronic acid-GPRC5C signalling promotes dormancy in haematopoietic stem cells
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Zhang, Yu Wei (University of Freiburg, Germany) ;
Mess, Julian (University of Freiburg, Germany) ;
Aizarani, Nadim (University of Freiburg, Germany) ;
Mishra, Pankaj (University of Freiburg, Germany) ;
Johnson, Carys (University of Cambridge, UK) ;
Romero-Mulero, Mari Carmen (University of Freiburg, Germany) ;
Rettkowski, Jasmin (University of Freiburg, Germany) ;
Schönberger, Katharina (University of Freiburg, Germany) ;
Obier, Nadine (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany) ;
Jäcklein, Karin (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany) ;
Woessner, Nadine M. (University of Freiburg, Germany) ;
Lalioti, Maria Eleni (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany) ;
Velasco-Hernández, Talia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Sikora, Katarzyna (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany) ;
Wäsch, Ralph (University of Freiburg, Germany) ;
Lehnertz, Bernhard (University of Montreal, Canada) ;
Sauvageau, Guy (University of Montreal, Canada) ;
Manke, Thomas (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany) ;
Menendez, Pablo (Institució Catalana de Recerca i Estudis Avançats) ;
Walter, Sebastian Gottfried (Uniklinik Köln (Colònia, Alemanya)) ;
Minguet, Susana (University of Freiburg, Germany) ;
Laurenti, Elisa (University of Cambridge, UK) ;
Günther, Stefan (University of Freiburg, Germany) ;
Grün, Dominic (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany) ;
Cabezas-Wallscheid, Nina (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany)
Bone marrow haematopoietic stem cells (HSCs) are vital for lifelong maintenance of healthy haematopoiesis. In inbred mice housed in gnotobiotic facilities, the top of the haematopoietic hierarchy is occupied by dormant HSCs, which reversibly exit quiescence during stress. [...]
2022 -  10.1038/s41556-022-00931-x
Nature Cell Biology, Vol. 24 Núm. 7 (july 2022) , p. 1038-1048
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2.
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15 p, 2.7 MB |
ALPL-1 is a target for chimeric antigen receptor therapy in osteosarcoma
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Mensali, Nadia (Department of Cellular Therapy. Oslo University Hospital) ;
Köksal, Hakan (Oslo University Hospital (Oslo, Noruega)) ;
Joaquina, Sandy (Oslo University Hospital (Oslo, Noruega)) ;
Wernhoff, Patrick (Oslo University Hospital (Oslo, Noruega)) ;
Casey, Nicholas P. (Oslo University Hospital (Oslo, Noruega)) ;
Romecín, Paola Alejandra (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Panisello, Carla (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Rodríguez, René (Instituto de Salud Carlos III) ;
Vimeux, Lene (Université de Paris) ;
Juzeniene, Asta (Oslo University Hospital (Oslo, Noruega)) ;
Myhre, Marit R. (Oslo University Hospital (Oslo, Noruega)) ;
Fåne, Anne (Oslo University Hospital (Oslo, Noruega)) ;
Castilla-Ramirez, Carolina (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Maggadottir, Solrun Melkork (Oslo University Hospital (Oslo, Noruega)) ;
Duru, Adil Doganay (Nova Southeastern University) ;
Georgoudaki, Anna-Maria (Department of Oncology-Pathology. Karolinska Institutet) ;
Grad, Iwona (Oslo University Hospital (Oslo, Noruega)) ;
Maturana, Andrés Daniel (Nagoya University) ;
Gaudernack, Gustav (Oslo University Hospital (Oslo, Noruega)) ;
Kvalheim, Gunnar (Department of Cellular Therapy. Oslo University Hospital) ;
Carcaboso, Angel M. (Institut de Recerca Sant Joan de Déu) ;
De Álava, Enrique (Universidad de Sevilla) ;
Donnadieu, Emma (Université de Paris) ;
Bruland, Øyvind S (University of Oslo) ;
Menendez, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Inderberg, Else Marit (Oslo University Hospital (Oslo, Noruega)) ;
Wälchli, Sébastien (Oslo University Hospital (Oslo, Noruega))
Osteosarcoma (OS) remains a dismal malignancy in children and young adults, with poor outcome for metastatic and recurrent disease. Immunotherapies in OS are not as promising as in some other cancer types due to intra-tumor heterogeneity and considerable off-target expression of the potentially targetable proteins. [...]
2023 - 10.1038/s41467-023-39097-x
Nature communications, Vol. 14 Núm. 1 (december 2023) , p. 3375
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3.
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18 p, 3.7 MB |
The KMT2A recombinome of acute leukemias in 2023
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Meyer, Claus (DCAL/Institute of Pharm. Biology. Goethe-University(Alemanya)) ;
Larghero, Patrizia (DCAL/Institute of Pharm. Biology. Goethe-University (Alemanya)) ;
Lopes, BA. (DCAL/Institute of Pharm. Biology. Goethe-University (Alemanya)) ;
Burmeister, Thomas (Charité - Universitätsmedizin Berlin) ;
Gröger, Daniela (Charité - Universitätsmedizin Berlin) ;
Sutton, Rosemary (Molecular Diagnostics. Children's Cancer Institute. Lowy Cancer Research Centre. UNSW (Sidney, Austràlia)) ;
Venn, Nicola C. (Molecular Diagnostics. Children's Cancer Institute. Lowy Cancer Research Centre. UNSW (Sidney, Austràlia)) ;
Cazzaniga, Giovanni (University of Milano-Bicocca/Fondazione Tettamanti (Itàlia)) ;
Corral Abascal, Lilia (University of Milano-Bicocca/Fondazione Tettamanti (Itàlia)) ;
Tsaur, Grigory А. (Research Institute of Medical Cell Technologies (Ekaterinburg, Rússia)) ;
Fechina, Larisa G. (Research Institute of Medical Cell Technologies (Ekaterinburg, Rússia)) ;
Emerenciano, Mariana (Instituto Nacional de Câncer (INCA)(Rio de Janeiro, Brasil)) ;
Pombo-de-Oliveira, Maria S. (Instituto Nacional de Câncer (INCA)(Rio de Janeiro, Brasil)) ;
Lund-Aho, Tiina (Laboratory of Clinical Genetics, Fimlab Laboratories (Tampere, Finlàndia)) ;
Lundán, Tuija (University of Turku and Turku University Hospital (Turku, Finlàndia)) ;
Montonen, M. (University of Turku and Turku University Hospital (Turku, Finlàndia)) ;
Juvonen, Vesa (University of Turku and Turku University Hospital (Turku, Finlàndia)) ;
Zuna, Jan (Charles University and University Hospital Motol (Praga, República Txeca)) ;
Trka, Jan M. (Charles University and University Hospital Motol (Praga, República Txeca)) ;
Ballerini, Paola (Pierre et Marie Curie University (París, França)) ;
Lapillonne, Hélène (Pierre et Marie Curie University (París, França)) ;
Van der Velden, Vincent (University Medical Center Rotterdam (Països Baixos)) ;
Sonneveld, Edwin (Princess Máxima Center for Pediatric Oncology (Utrecht, Països Baixos)) ;
Delabesse, Éric C. M. (Institut Universitaire du Cancer de Toulouse (França)) ;
Capela de Matos, Roberto (National Cancer Institute (INCA) (Rio de Janeiro, Brasil)) ;
Silva, Maria Luiza (National Cancer Institute (INCA) (Rio de Janeiro, Brasil)) ;
Bomken, Simon (Newcastle University, Newcastle upon Tyne (Regne Unit)) ;
Katsibardi, Katerina (National and Kapodistrian University of Athens, "Aghia Sophia" Children's Hospital (Atenes, Grècia)) ;
Keernik, Maria (Tartu University Hospital (Tartu, Estònia)) ;
Grardel, Nathalie (University Hospital Claude Huriez) ;
Mason, J. (Newcastle University and the Great North Children's West Midlands Regional Genetics Laboratory (Regne Unit)) ;
Price, Richard (Newcastle University and the Great North Children's West Midlands Regional Genetics Laboratory (Regne Unit)) ;
Kim, J. (DCAL/Institute of Pharm. Biology. Goethe-University (Alemanya)) ;
Eckert, Cornelia (Charité - Universitätsmedizin Berlin) ;
Lo Nigro, Luca (Centro di Riferimento Regionale di Ematologia ed Oncologia Pediatrica, Azienda Policlinico "G. Rodolico" (Catània, Itàlia)) ;
Bueno, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Menéndez Bujan, Pablo (Centro di Riferimento Regionale di Ematologia ed Oncologia Pediatrica, Azienda Policlinico "G. Rodolico" (Catània, Itàlia)) ;
Zur Stadt, Udo (University Medical Center Hamburg-Eppendorf (Hamburg, Alemanya)) ;
Gameiro, Paula (Instituto Português de Oncologia, Departament of Hematology (Lisboa, Portugal)) ;
Sedek, Łukasz (Medical University of Silesia (Zabrze, Polònia)) ;
Szczepanski, Tomasz (Medical University of Silesia (Zabrze, Polònia)) ;
Bidet, A. (Laboratoire d'Hématologie Biologique, CHU Bordeaux (França)) ;
Marcu, Victoria (Hematology Laboratory, Sheba Medical Center, Tel-Hashomer, Israel) ;
Shichrur, Keren (Schneider Children's Medical Center of Israel, Petah Tikva, Israel) ;
Izraeli, Shai (Tel Aviv University, Tel Aviv, Israel) ;
Madsen, Hans Ole (Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark) ;
Schäfer, Beat (University Children's Hospital Zurich (Zúric, Suïssa)) ;
Kubetzko, Susanne (University Children's Hospital Zurich (Zúric, Suïssa)) ;
Kim, Rathana (Université Paris Cité (França)) ;
Clappier, Emmanuelle (Université Paris Cité (França)) ;
Trautmann, Heiko (University Hospital Schleswig-Holstein (Kiel, Alemanya)) ;
Brüggemann, Monika (University Hospital Schleswig-Holstein (Kiel, Alemanya)) ;
Archer, Paul (Bristol Genetics Laboratory, North Bristol NHS Trust (Bristol, Regne Unit)) ;
Hancock, Jeremy P. (Bristol Genetics Laboratory, North Bristol NHS Trust (Bristol, Regne Unit)) ;
Alten, Julia (University Hospital Schleswig-Holstein (Kiel, Alemanya)) ;
Möricke, Anja (University Hospital Schleswig-Holstein (Kiel, Alemanya)) ;
Stanulla, Martin (Department of Pediatrics, MHH (Hanover, Alemanya)) ;
Lentes, Jana (Medical School Hannover (Alemanya)) ;
Bergmann, Anke K. (Medical School Hannover (Alemanya)) ;
Strehl, Sabine (St. Anna Children's Cancer Research Institute (CCRI) (Vienna, Àustria)) ;
Köhrer, Stefan (St. Anna Children's Cancer Research Institute (CCRI) (Vienna, Àustria)) ;
Nebral, Karin (St. Anna Children's Cancer Research Institute (CCRI) (Vienna, Àustria)) ;
Dworzak, Michael Norbert (St. Anna Children's Cancer Research Institute (CCRI) (Vienna, Àustria)) ;
Haas, Oskar A. (St. Anna Children's Cancer Research Institute (CCRI) (Vienna, Àustria)) ;
Arfeuille, Chloe (Hopital Robert Debré (París, França)) ;
Caye Eude, Aurélie (Hopital Robert Debré (París, França)) ;
Cavé, Hélène (Hopital Robert Debré (París, França)) ;
Marschalek, Rolf (Goethe-University (Alemanya))
Chromosomal rearrangements of the human KMT2A/MLL gene are associated with de novo as well as therapy-induced infant, pediatric, and adult acute leukemias. Here, we present the data obtained from 3401 acute leukemia patients that have been analyzed between 2003 and 2022. [...]
2023 - 10.1038/s41375-023-01877-1
Leukemia, Vol. 37 Núm. 5 (may 2023) , p. 988-1005
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16 p, 3.4 MB |
Low input capture Hi-C (liCHi-C) identifies promoter-enhancer interactions at high-resolution
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Tomás Daza, Laureano (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Rovirosa, Llorenç (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
López-Martí, Paula (Barcelona Supercomputing Center) ;
Nieto-Aliseda, Andrea (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Serra, François (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Planas-Riverola, Ainhoa (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Molina, Oscar (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
McDonald, Rebecca (Wellcome-MRC Cambridge Stem Cell Institute) ;
Ghevaert, Cedric (NHS Blood and Transplant) ;
Cuatrecasas, Esther (Hospital Sant Joan de Déu (Manresa)) ;
Costa, Dolors (Cancer Network Biomedical Research Center) ;
Camós, Mireia (Instituto de Salud Carlos III) ;
Bueno, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Menéndez, Pablo (Institució Catalana de Recerca i Estudis Avançats) ;
Valencia, Alonso (Institució Catalana de Recerca i Estudis Avançats) ;
Javierre, B. M (Institut Germans Trias i Pujol)
Long-range interactions between regulatory elements and promoters are key in gene transcriptional control; however, their study requires large amounts of starting material, which is not compatible with clinical scenarios nor the study of rare cell populations. [...]
2023 - 10.1038/s41467-023-35911-8
Nature communications, Vol. 14 Núm. 1 (december 2023) , p. 268
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9 p, 686.2 KB |
The relapsed acute lymphoblastic leukemia network (ReALLNet) : a multidisciplinary project from the spanish society of pediatric hematology and oncology (SEHOP)
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Velasco, Pablo (Hospital Universitari Vall d'Hebron) ;
Bautista, Francisco (Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands) ;
Rubio, Alba (Hospital Infantil Universitario Niño Jesús (Madrid)) ;
Aguilar, Yurena (Hospital Miguel Servet Hospital) ;
Rives, Susana (Hospital Sant Joan de Déu (Barcelona, Catalunya)) ;
Dapena, Jose L (Hospital Sant Joan de Déu (Barcelona, Catalunya)) ;
Pérez, Antonio (Universidad Autónoma de Madrid) ;
Ramirez, Manuel (Fundación para la Investigación Biomédica Hospital Infantil Universitario Niño Jesús) ;
Saiz-Ladera, Cristina (Fundación para la Investigación Biomédica Hospital Infantil Universitario Niño Jesús) ;
Izquierdo, Elisa (Hospital Universitario La Paz (Madrid)) ;
Escudero, Adela (Hospital Universitario La Paz (Madrid)) ;
Camós, Mireia (Hospital Sant Joan de Déu (Barcelona, Catalunya)) ;
Vega-García, Nerea (Hospital Sant Joan de Déu (Barcelona, Catalunya)) ;
Ortega, Margarita (Vall d'Hebron Institut d'Oncologia) ;
Hidalgo-Gómez, Gloria (Vall d'Hebron Institut d'Oncologia) ;
Palacio, Carlos (Vall d'Hebron Institut d'Oncologia) ;
Menéndez, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bueno, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Montero, Joan (Universitat de Barcelona) ;
Romecín, Paola A. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Zazo, Santiago (Universidad Politécnica de Madrid) ;
Alvarez, Federico (Universidad Politécnica de Madrid) ;
Parras, Juan (Universidad Politécnica de Madrid) ;
Ortega-Sabater, Carmen (University of Castilla-La Mancha) ;
Chulián, Salvador (Universidad de Cádiz) ;
Rosa, María (Universidad de Cádiz) ;
Cirillo, Davide (Barcelona Supercomputing Center) ;
García, Elena (Fundación para la Investigación Biomédica Hospital Infantil Universitario Niño Jesús) ;
García, Jorge (Fundación para la Investigación Biomédica Hospital Infantil Universitario Niño Jesús) ;
Manzano-Muñoz, Albert (Universitat de Barcelona) ;
Minguela, Alfredo (Instituto Murciano de Investigación Biosanitaria) ;
Fuster, José Luis (Instituto Murciano de Investigación Biosanitaria)
Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, with survival rates exceeding 85%. However, 15% of patients will relapse; consequently, their survival rates decrease to below 50%. [...]
2023 - 10.3389/fped.2023.1269560
Frontiers in Pediatrics, Vol. 11 (september 2023)
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7.
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5 p, 1.3 MB |
TIM3, a human acute myeloid leukemia stem cell marker, does not enrich for leukemia-initiating stem cells in B-cell acute lymphoblastic leukemia
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Bueno, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Martínez, Alba (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Romecin, Paola Alejandra (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Zanetti, S. R (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Tirtakusuma, Ricky (Newcastle University) ;
Genesca, Eulalia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Camós, Mireia (Institut de Recerca Sant Joan de Déu) ;
Ramírez-Orellana, Manuel (Instituto de Salud Carlos III) ;
Anguita, Eduardo (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Ballerini, Paola (Armand Trosseau Hospital, Paris) ;
Locatelli, Franco (Ospedale Bambino Gesú. Rome) ;
Fuster, José Luis (Instituto Murciano de Investigación Biosanitaria) ;
Menéndez, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
2023 - 10.3324/haematol.2022.282394
Haematologica, Vol. 108 Núm. 8 (august 2023) , p. 2229-2231
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7 p, 1.1 MB |
Epigenome profiling reveals aberrant DNA methylation signature in GATA2 deficiency
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Marin-Bejar, Oskar (Institut d'Investigació Biomèdica de Bellvitge) ;
Romero-Moya, Damia (Institut d'Investigació Biomèdica de Bellvitge) ;
Rodriguez-Ubreva, Javier (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Distefano, Maximiliano (Hospital Sant Joan de Déu (Manresa)) ;
Lessi, Francesca (Fondazione Pisana Per la Scienza ONLUS (FPS)) ;
Aretini, Paolo (Fondazione Pisana Per la Scienza ONLUS (FPS)) ;
Liquori, Alessandro (Instituto de Salud Carlos III) ;
Castaño, Julio (Banc de Sang i Teixits) ;
Kozyra, Emilia (University of Freiburg) ;
Kotmayer, Lili (Semmelweis University. Budapest, Hungary) ;
Bueno, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Cervera, José (Hospital Universitari i Politècnic La Fe (València)) ;
Rodriguez-Gallego, José Carlos (University of Las Palmas de Gran Canaria) ;
Nomdedeu, Josep Francisco (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Murillo- Sanjuán, Laura (Vall d'Hebron Institut d'Oncologia) ;
de Heredia, Cristina Díaz (Vall d'Hebron Institut d'Oncologia) ;
Pérez-Martinez, Antonio (Universidad Autónoma de Madrid) ;
López-Cadenas, Félix (Instituto Biosanitario de Salamanca (IBSAL)) ;
Martínez-Laperche, Carolina (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM)) ;
Dorado-Herrero, Nieves (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM)) ;
Marco, Francisco M. (Institute for Health and Biomedical Research (ISABIAL)) ;
Prósper, Felipe (Instituto de Salud Carlos III) ;
Menendez, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Valcárcel, David (Vall d'Hebron Institut d'Oncologia) ;
Ballestar, Esteban (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bödör, Csaba (Semmelweis University. Budapest, Hungary) ;
Bigas Salvans, Anna (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Catalá, Albert (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Wlodarski, Marcin W. (St. Jude Children's Research Hospital, Memphis, TN) ;
Giorgetti, Alessandra (Institut d'Investigació Biomèdica de Bellvitge) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
2023 - 10.3324/haematol.2022.282305
Haematologica, Vol. 108 Núm. 9 (september 2023) , p. 2551-2557
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9.
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29 p, 5.2 MB |
Chromosomal instability in aneuploid acute lymphoblastic leukemia associates with disease progression
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Molina, Oscar (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ortega-Sabater, C. (Mathematical Oncology Laboratory. Department of Mathematics & amp; Institute of Applied Mathematics in Science and Engineering. Universidad de Castilla-La Mancha) ;
Thampi, Namitha (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Fernández Fuentes, Narcís (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Guerrero Murillo, Mercedes (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Martínez Moreno, Alba (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Vinyoles, Meritxell (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Velasco-Hernández, Talia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bueno, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Trincado Alonso, Juan Luis, 1987- (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Granada, Isabel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Campos, Diana (DiNA Science. S.A) ;
Giménez, Carles (DiNA Science. S.A) ;
Boer, Judith M. (Princess Maxima Center for Pediatric Oncology) ;
den Boer, Monique L. (Department of Pediatric Oncology and Hematology. Erasmus Medical Center - Sophia Children's Hospital) ;
Calvo, Gabriel F. (Mathematical Oncology Laboratory. Department of Mathematics & amp; Institute of Applied Mathematics in Science and Engineering. Universidad de Castilla-La Mancha) ;
Camós, Mireia (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Fuster, José Luis (Instituto Murciano de Investigación Biosanitaria) ;
Velasco, P. (Hospital Universitari Vall d'Hebron) ;
Ballerini, Paola (AP-HP. Service of Pediatric Hematology. Hopital Armand Trousseau) ;
Locatelli, Franco (Bambino Gesù Children's Hospital) ;
Mullighan, Charles G. (Department of Pathology. St. Jude Children's Research Hospital) ;
Spierings, Diana C.J. (European Research Institute for the Biology of Aging (ERIBA). University of Groningen. University Medical Center Groningen) ;
Foijer, Floris (European Research Institute for the Biology of Aging (ERIBA). University of Groningen. University Medical Center Groningen) ;
Pérez-García, Víctor M. (Mathematical Oncology Laboratory. Department of Mathematics & amp; Institute of Applied Mathematics in Science and Engineering. Universidad de Castilla-La Mancha) ;
Menéndez Bujan, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Chromosomal instability (CIN) lies at the core of cancer development leading to aneuploidy, chromosomal copy-number heterogeneity (chr-CNH) and ultimately, unfavorable clinical outcomes. Despite its ubiquity in cancer, the presence of CIN in childhood B-cell acute lymphoblastic leukemia (cB-ALL), the most frequent pediatric cancer showing high frequencies of aneuploidy, remains unknown. [...]
2024 - 10.1038/s44321-023-00006-w
EMBO Molecular Medicine, Vol. 16 Núm. 1 (16 2024) , p. 64-92
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14 p, 1.6 MB |
Overcoming CAR-Mediated CD19 Downmodulation and Leukemia Relapse with T Lymphocytes Secreting Anti-CD19 T-cell Engagers
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Blanco, Belén (Red Española de Terapias Avanzadas (TERAV)) ;
Ramírez-Fernández, Ángel (Immuno-Oncology and Immunotherapy Group. Instituto de Investigación Sanitaria 12 de Octubre (imas12)) ;
Bueno, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Argemí-Muntadas, Lidia (Aarhus University, Denmark) ;
Fuentes, Patricia (Centro de Biología Molecular Severo Ochoa CSIC-UAM) ;
Aguilar-Sopeña, Óscar (Instituto de Investigación Sanitaria 12 de Octubre (imas12)) ;
Gutierrez-Agüera, Francisco (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Zanetti, S. R (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Tapia-Galisteo, Antonio (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Díez-Alonso, Laura (Instituto de Investigación Sanitaria 12 de Octubre (imas12)) ;
Segura-Tudela, Alejandro (Instituto de Investigación Sanitaria 12 de Octubre (imas12)) ;
Castellà, Maria (Hospital Clínic i Provincial de Barcelona) ;
Marzal, Berta (Hospital Clínic i Provincial de Barcelona) ;
Betriu-Méndez, Sergi (Hospital Clínic i Provincial de Barcelona) ;
Harwood, Seandean L. (Aarhus University, Denmark) ;
Compte, Marta (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Lykkemark, Simon (Aarhus University, Denmark) ;
Erce-Llamazares, Ainhoa (Instituto de Investigación Sanitaria 12 de Octubre (imas12)) ;
Rubio-Pérez, Laura (Universidad Francisco de Vitoria (UFV). Pozuelo de Alarcón) ;
Jiménez-Reinoso, Anaïs (Instituto de Investigación Sanitaria 12 de Octubre (imas12)) ;
Domínguez-Alonso, Carmen (Instituto de Investigación Sanitaria 12 de Octubre (imas12)) ;
Neves, Maria (Centro de Biología Molecular Severo Ochoa CSIC-UAM) ;
Morales, Pablo (Hospital 12 de Octubre (Madrid)) ;
Paz-Artal, Estela (Department of Immunology Ophthalmology and ENT. School of Medicine. Universidad Complutense) ;
Guedan, Sonia (Hospital Clínic i Provincial de Barcelona) ;
Sanz, Laura (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Toribio, Maria L. (Centro de Biología Molecular Severo Ochoa CSIC-UAM) ;
Roda-Navarro, Pedro (Instituto de Investigación Sanitaria 12 de Octubre (imas12)) ;
Juan, Manel (Hospital Clínic i Provincial de Barcelona) ;
Menéndez Bujan, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Álvarez-Vallina, Luis (Hospital 12 de Octubre (Madrid))
Chimeric antigen receptor (CAR)-modified T cells have revolutionized the treatment of CD19-positive hematologic malignancies. Although anti-CD19 CAR-engineered autologous T cells can induce remission in patients with B-cell acute lymphoblastic leukemia, a large subset relapse, most of them with CD19-positive disease. [...]
2022 - 10.1158/2326-6066.CIR-21-0853
Cancer Immunology Research, Vol. 10 Núm. 4 (april 2022) , p. 498-511
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