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Effectiveness and safety of tocilizumab in patients with systemic sclerosis : a propensity score matched controlled observational study of the EUSTAR cohort / Kuster, Simon (Department of Rheumatology. University Hospital Zurich. University of Zurich) ; Jordan, Suzana (Department of Rheumatology. University Hospital Zurich. University of Zurich) ; Elhai, Muriel (Université Paris Cité) ; Held, Ulrike (Department of Biostatistics at Epidemiology. Biostatistics and Prevention Institute. University of Zurich) ; Steigmiller, Klaus (Department of Biostatistics at Epidemiology. Biostatistics and Prevention Institute. University of Zurich) ; Bruni, Cosimo (Department of Experimental and Clinical Medicine. Division of Rheumatology. University of Florence) ; Cacciapaglia, Fabio (Rheumatology Unit. Deto. University Hospital Polyclinic of Bari) ; Vettori, Serena (Department of Precision Medicine. University of Campania Luigi Vanvitelli) ; Siegert, Elise (Berlin Institute of Health at Charité) ; Rednic, Simona (Clinica Reumatologie. University of Medicine and Pharmacy) ; Codullo, Veronica (Department of Rheumatology. Irccs Foundation Policlinico San Matteo) ; Airò, Paolo (Uoc Rheumatology and Clinical Immunology. Spedali Civili di Brescia) ; Braun-Moscovici, Yolanda (B. Shine Department of Rheumatology. Rambam Health Care Campus and Technion) ; Hunzelmann, Nicolas (University of Cologne) ; Joao Salvador, Maria (Department of Rheumatology. Centro Hospitalar e Universitário de Coimbra) ; Riccieri, Valeria (Department of Clinical Internal. Anesthesiological and Cardiovascular Sciences. Sapienza University of Rome) ; Gheorghiu, Ana-Maria (Dr Carol Davila University of Medicine and Pharmacy (Bucarest, Romania)) ; Alegre-Sancho, Juan José (Hospital Universitari Doctor Peset (València)) ; Romanowska-Prochnicka, Katarzyna (Department of Connective Tissues Diseases. Institute of Rheumatology) ; Castellvi, Ivan (Institut d'Investigació Biomèdica Sant Pau) ; Kötter, Ina (University Hospital Hamburg-Eppendorf. Division of Rheumatology and Systemic Inflammatory Diseases) ; Truchetet, Marie-Elise (Hospital General Universitario Gregorio Marañón) ; López-Longo, F.J. (Department of Rheumatology. National Reference Center for Systemic Autoimmune Rare Diseases. Hopital Pellegrin) ; Novikov, Pavel I. (Department of Rheumatology. National Reference Center for Systemic Autoimmune Rare Diseases. Hopital Pellegrin) ; Giollo, Alessandro (Rheumatology Section. Department of Medicine. University of Verona) ; Shirai, Yuichiro (Department of Allergy and Rheumatology. Nippon Medical School) ; Belloli, Laura (Rheumatology Unit. Asst Grande Ospedale Metropolitano Niguarda) ; Zanatta, Elisabetta (Rheumatology Unit. Department of Clinical and Experimental Medicine. University of Padova) ; Hachulla, Eric (Université de Lille) ; Smith, Vanessa (Unit for Molecular Immunology and Inflammation. Vib Inflammation Research Centre (IRC)) ; Denton, Christopher P. (Centre for Rheumatology. University College London Medical School. Royal Free Campus) ; Ionescu, Ruxandra M. (Internal Medicine and Rheumatology Department. St. Maria Hospital. Carol Davila University of Medicine and Pharmacy) ; Schmeiser, Tim (Krankenhaus St. Josef) ; Distler, Joerg H.W. (Department of Internal Medicine Iii. Erlangen University Hospital) ; Gabrielli, Armando (Dipartimento di Scienze Cliniche e Molecolari. Università Politecnica Delle Marche) ; Hoffmann-Vold, Anna-Maria (Department of Rheumatology. Rikshospitalet University Hospital Oslo) ; Kuwana, Masataka (Nippon Medical School Graduate School of Medicine) ; Allanore, Yannick (Université Paris Cité) ; Distler, Oliver (Department of Rheumatology. University Hospital Zurich. University of Zurich)
Objectives Tocilizumab showed trends for improving skin fibrosis and prevented progression of lung fibrosis in systemic sclerosis (SSc) in randomised controlled clinical trials. We aimed to assess safety and effectiveness of tocilizumab in a real-life setting using the European Scleroderma Trial and Research (EUSTAR) database. [...]
2022 - DOI (Digital Object Identifier)

10.1136/rmdopen-2022-002477
RMD Open, Vol. 8 Núm. 2 (march 2022) , p. e002477

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