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11 p, 1007.0 KB |
Targeted therapy or immunotherapy in BRAF-mutated metastatic melanoma : a Spanish center's decade of experience
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Sun, Chen (Department of Radiation Oncology, The Second Affiliated Hospital of Zhengzhou University) ;
España, Sofia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Richarz, Nina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Solé-Blanch, Carme (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Boada, Aram (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martinez-Cardús, Anna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Chu, Alan (Department of Radiation Oncology, The Second Affiliated Hospital of Zhengzhou University) ;
Liu, Zongwen (Department of Radiation Oncology, The Second Affiliated Hospital of Zhengzhou University) ;
Manzano, Jose Luis (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Targeted therapies and immunotherapy are currently considered the mainstay first-line treatment for advanced BRAF-mutated melanoma. However, the impact of treatment (targeted therapy and immunotherapy) and the prognostic factors are still not clear. [...]
2024 -  10.3389/fonc.2024.1322116
Frontiers in Oncology, Vol. 14 (february 2024)
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14 p, 8.8 MB |
Peripheral Organ Equivalent Dose Estimation Procedure in Proton Therapy
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Domingo, Carles (Universitat Autònoma de Barcelona. Departament de Física) ;
Lagares, Juan Ignacio (Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (Espanya)) ;
Romero-Expósito, Maite (The Skandion Clinic) ;
Sánchez-Nieto, Beatriz (Pontificia Universidad Católica de Chile.Instituto de Física) ;
Nieto-Camero, Jaime J. (iThemba Labs) ;
Terrón, Jose Antonio (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Irazola, Leticia (Clínica Universidad de Navarra. Servicio de Radiofísica y Protección Radiológic) ;
Dasu, Alexandru (Uppsala University. Department of Immunology, Genetics and Pathology) ;
Sánchez-Doblado, Francisco (Universidad de Sevilla. Departamento Fisiología Médica y Biofísica)
The aim of this work is to present a reproducible methodology for the evaluation of total equivalent doses in organs during proton therapy facilities. The methodology is based on measuring the dose equivalent in representative locations inside an anthropomorphic phantom where photon and neutron dosimeters were inserted. [...]
2022 - 10.3389/fonc.2022.882476
Frontiers in Oncology, Vol. 12 (May 2022) , art. 882476
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13 p, 5.1 MB |
Neutron Radiation Dose Measurements in a Scanning Proton Therapy Room : Can Parents Remain Near Their Children During Treatment?
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Mares, Vladimir (Institute of Radiation Medicine. Helmholtz Zentrum München) ;
Farah, Jad (Institut de Radioprotection et de Sûreté Nucléaire) ;
De Saint-Hubert, Marijke (Institute for Environment, Health and Safety. Belgian Nuclear Research Center) ;
Domański, Szymon (National Centre for Nuclear Research. Radiological Metrology and Biomedical Physics Division) ;
Domingo, Carles (Universitat Autònoma de Barcelona. Departament de Física) ;
Dommert, Martin (Institute of Radiation Medicine. Helmholtz Zentrum München) ;
Kłodowska, Magdalena (Cambridge University Hospital National Health Service) ;
Krzempek, Katarzyna (Polish Academy of Sciences. Institute of Nuclear Physics) ;
Kuć, Michal (National Centre for Nuclear Research. Radiological Metrology and Biomedical Physics Division) ;
Martínez-Rovira, Immaculada (Universitat Autònoma de Barcelona. Departament de Física) ;
Michaś, Edyta (National Centre for Nuclear Research. Radiological Metrology and Biomedical Physics Division) ;
Mojżeszek, Natalia (Polish Academy of Sciences. Institute of Nuclear Physics) ;
Murawski, Łukasz (National Centre for Nuclear Research. Radiological Metrology and Biomedical Physics Division) ;
Ploc, Ondrej (Nuclear Physics Institute of the Czech Academy of Sciences. Department of Radiation Dosimetry) ;
Romero-Expósito, Maite (The Skandion Clinic (Sweden)) ;
Tisi, Marco (Institute of Radiation Medicine. Helmholtz Zentrum München) ;
Trompier, François (Institut de Radioprotection et de Sûreté Nucléaire) ;
Van Hoey, Olivier (Institute for Environment. Health and Safety. Belgian Nuclear Research Center) ;
Van Ryckeghem, Laurent (Institut de Radioprotection et de Sûreté Nucléaire) ;
Wielunski, Marek (Institute of Radiation Medicine. Helmholtz Zentrum München) ;
Harrison, Roger M. (University of Newcastle upon Tyne) ;
Stolarczyk, Liliana (Aarhus University Hospital. Danish Centre for Particle Therapy) ;
Olko, Pawel (Polish Academy of Sciences. Institute of Nuclear Physics)
Purpose: This study aims to characterize the neutron radiation field inside a scanning proton therapy treatment room including the impact of different pediatric patient sizes. Materials and Methods: Working Group 9 of the European Radiation Dosimetry Group (EURADOS) has performed a comprehensive measurement campaign to measure neutron ambient dose equivalent, H*(10), at eight different positions around 1-, 5-, and 10-year-old pediatric anthropomorphic phantoms irradiated with a simulated brain tumor treatment. [...]
2022 - 10.3389/fonc.2022.903706
Frontiers in Oncology, Vol. 12 (July 2022) , art. 903706
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14 p, 7.0 MB |
Out-of-Field Doses Produced by a Proton Scanning Beam Inside Pediatric Anthropomorphic Phantoms and Their Comparison With Different Photon Modalities
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Knežević, Ž. (Ruđer Bošković Institute) ;
Stolarczyk, L. (Institute of Nuclear Physics) ;
Ambrožová, I. (Nuclear Physics Institute of the Czech Academy of Sciences) ;
Caballero-Pacheco, Miguel Ángel (Universitat Autònoma de Barcelona) ;
Davídková, M. (Nuclear Physics Institute of the Czech Academy of Sciences) ;
De Saint-Hubert, M. (Belgium Nuclear Research Centre) ;
Domingo, C. (Universitat Autònoma de Barcelona) ;
Jeleń, K. (Cracow University of Technology) ;
Kopeć, R. (Institute of Nuclear Physics) ;
Krzempek, D. (Institute of Nuclear Physics) ;
Majer, M. (Ruđer Bošković Institute) ;
Miljanić, S. (Ruđer Bošković Institute) ;
Mojżeszek, N. (Institute of Nuclear Physics) ;
Romero-Expósito, M. (Skandion Clinic) ;
Martínez-Rovira, Immaculada (Universitat Autònoma de Barcelona) ;
Harrison, R.M. (University of Newcastle upon Tyne) ;
Olko, P. (Institute of Nuclear Physics)
Since 2010, EURADOS Working Group 9 (Radiation Dosimetry in Radiotherapy) has been involved in the investigation of secondary and scattered radiation doses in X-ray and proton therapy, especially in the case of pediatric patients. [...]
2022 - 10.3389/fonc.2022.904563
Frontiers in Oncology, Vol. 12 (22 2022) , p. 904563
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16 p, 11.9 MB |
MET Inhibition Sensitizes Rhabdomyosarcoma Cells to NOTCH Signaling Suppression
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Perrone, Clara (University of Rome) ;
Pomella, Silvia (Bambino Gesù Children's Hospital) ;
Cassandri, Matteo (Sapienza University) ;
Pezzella, Michele (Bambino Gesù Children's Hospital) ;
Milano, Giuseppe Maria (Bambino Gesù Children's Hospital) ;
Colletti, Marta (Bambino Gesù Children's Hospital) ;
Cossetti, Cristina (Bambino Gesù Children's Hospital) ;
Pericoli, Giulia (Bambino Gesù Children's Hospital) ;
Di Giannatale, Angela (Bambino Gesù Children's Hospital) ;
de Billy, Emmanuel (Bambino Gesù Children's Hospital) ;
Vinci, Maria (Bambino Gesù Children's Hospital) ;
Petrini, Stefania (Bambino Gesù Children's Hospital) ;
Marampon, Francesco (Sapienza University) ;
Quintarelli, Concetta (University of Naples Federico II) ;
Taulli, Riccardo (University of Torino) ;
Roma, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gallego, Soledad (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Camero, Simona (University of Rome) ;
Mariottini, Paolo (University of Rome) ;
Cervelli, Manuela (University of Rome) ;
Maestro, Roberta (National Cancer Institute) ;
Miele, Lucio (Louisiana State University Health Sciences Center) ;
De Angelis, Biagio (Bambino Gesù Children's Hospital) ;
Locatelli, Franco (Sapienza University) ;
Rota, Rossella (Bambino Gesù Children's Hospital) ;
Universitat Autònoma de Barcelona
Rhabdomyosarcoma (RMS) is a pediatric myogenic soft tissue sarcoma. The Fusion-Positive (FP) subtype expresses the chimeric protein PAX3-FOXO1 (P3F) while the Fusion-Negative (FN) is devoid of any gene translocation. [...]
2022 - 10.3389/fonc.2022.835642
Frontiers in Oncology, Vol. 12 (april 2022)
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11 p, 2.0 MB |
National expert consensus on home-administered oncologic therapies in Spain
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Villegas, Eulalia (Hospital Dos de Maig (Barcelona, Catalunya)) ;
Arruñada, María (Pharmacoeconomics & Outcomes Research Iberia (PORIB)) ;
Casado, Miguel Ángel (Pharmacoeconomics & Outcomes Research Iberia (PORIB)) ;
González, Sonia (University Hospital Complex of Vigo (SERGAS-UVIGO)) ;
Moreno-Martínez, María Estela (Institut d'Investigació Biomèdica Sant Pau) ;
Peñuelas, María Ángeles (Hospital Universitari Vall d'Hebron) ;
Torres, Ana Maria (Hospital Dos de Maig (Barcelona, Catalunya)) ;
Sierra, Yanik (Eisai Farmaceutica SA) ;
Seguí, Miguel Angel (Universitat Autònoma de Barcelona. Departament de Medicina)
The diagnosis and treatment of cancer impose a significant emotional and psychological burden on patients, families, and caregivers. Patients undergo several interventions in a hospital setting, and the increasing number of patients requiring extended care and follow-up is driving the demand for additional clinical resources to address their needs. [...]
2024 - 10.3389/fonc.2024.1335344
Frontiers in Oncology, Vol. 14 (february 2024)
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12 p, 1.6 MB |
Integrated analysis of randomized controlled trials evaluating bortezomib + lenalidomide + dexamethasone or bortezomib + thalidomide + dexamethasone induction in transplant-eligible newly diagnosed multiple myeloma
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Rosiñol, Laura (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Hebraud, Benjamin (Institut Universitaire du Cancer de Toulouse-Oncopole) ;
Oriol, Albert (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Colin, Anne-Laurène (Ser Centre Hospitalier et Universitaire de Toulouse) ;
Ríos Tamayo, Rafael (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Hulin, Cyrille (Department of Hematology. Hôpital Haut-Lévêque) ;
Blanchard, María Jesús (Hospital Universitario Ramón y Cajal (Madrid)) ;
Caillot, Denis (Hôpital du Bocage) ;
Sureda, Anna (Universitat de Barcelona) ;
Hernández, Miguel Teodoro (Hospital Universitario de Canarias (La Laguna)) ;
Arnulf, Bertrand (Hôpital St-Louis) ;
Mateos, M. V (Instituto de Investigación Biomédica de Salamanca) ;
Macro, Margaret (Centre Hospitalier et Universitaire de Caen) ;
San-Miguel, J (Clínica Universidad de Navarra) ;
Belhadj, Karim (Centre Hospitalier et Universitaire Henri Mondor) ;
Lahuerta, J. J (Clínica Universidad de Navarra) ;
Garelik, M.Brigid (Bristol-Myers Squibb Company) ;
Bladé Creixenti, Juan (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Moreau, Philippe (University Hospital Hôtel-Dieu, Nantes, France)
Objective: Providing the most efficacious frontline treatment for newly diagnosed multiple myeloma (NDMM) is critical for patient outcomes. No direct comparisons have been made between bortezomib + lenalidomide + dexamethasone (VRD) and bortezomib + thalidomide + dexamethasone (VTD) induction regimens in transplant-eligible NDMM. [...]
2023 - 10.3389/fonc.2023.1197340
Frontiers in Oncology, Vol. 13 (2023) , p. 1197340
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6 p, 870.5 KB |
Characterization of a cohort of metastatic lung cancer patients harboring KRAS mutations treated with immunotherapy : differences according to KRAS G12C vs. non-G12C
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Notario, Lucía (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Cucurull, Marc (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Cerdà, Gabriela (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sanz, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Carcereny, Enric (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Muñoz-Mármol, Ana (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Hernández, Ainhoa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Domènech, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Morán, Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sanchez-Cespedes, Montse (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Costa, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Mate, Jose Luis (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Esteve, Anna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Saigí, Maria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Approximately 20% of lung adenocarcinomas harbor activating mutations at KRAS, an oncogene with the ability to alter the tumor immune microenvironment. In this retrospective study, we examined 103 patients with KRAS-mutant lung adenocarcinoma who were treated with immunotherapy-based regimens and we evaluated the clinical outcomes according to PD-L1 expression and the type of KRAS mutation. [...]
2023 - 10.3389/fonc.2023.1239000
Frontiers in Oncology, Vol. 13 (october 2023)
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