In recent years, use of genetic recombination technology for introducing foreign genes into living organisms has been developed, and genetically modified soybeans and corn strains with traits such as herbicide and pest resistance have been widely cultivated all over the world. Strict safety assessments and management of genetically modified crops are carried out by the governments of each country. In the 21st century, genome editing technology based on the ability to cleave a specific site of chromosomal DNA has been put to practical use, and many genome edited crops and livestock have been developed. Therefore, in Japan, the Ministry of Health, Labor and Welfare (MHLW) has established regulations regarding handling of foods to which genome editing technology is applied. Genome-edited foods contain no foreign genes and are obtained by modifying or destroying native genes. Therefore, it is considered to have the same level of safety as crops produced by conventional breeding methods. Developers of genome-edited foods are required to notify the MHLW, and the MHLW will confirm the outline of genome editing and the absence of foreign genes through prior consultation. In December 2020, the first application for high gamma aminobutyric acid (GABA)-containing tomatoes produced by genome editing was accepted by MHLW, paving the way for distribution and sales.