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[[File:Mycobacterium tuberculosis.jpg|thumb|upright=1.36|[[Scanning electron micrograph]] of ''[[Mycobacterium tuberculosis]]'', a [[bacteria|bacterium]] that causes [[tuberculosis]]]]
A '''disease''' is a particular abnormal condition that negatively affects the [[structure]] or [[function (biology)|function]] of all or part of an organism, and that is not due to any immediate external injury.<ref name=":1"
In humans, ''disease'' is often used more broadly to refer to any condition that causes [[pain]], [[Abnormality (behavior)|dysfunction]], [[distress (medicine)|distress]], [[social problems]], or [[death]] to the person afflicted, or similar problems for those in contact with the person. In this broader sense, it sometimes includes [[injury|injuries]], [[disability|disabilities]], [[Disease#disorder|disorders]], [[syndrome]]s, [[infection]]s, isolated [[symptom]]s, deviant [[behavior]]s, and atypical [[human variability|variations]] of structure and function, while in other contexts and for other purposes these may be considered distinguishable categories. Diseases can affect people not only physically, but also mentally, as contracting and living with a disease can alter the affected person's perspective on life.
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