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Interventional and non-interventional methods to detect atherosclerosis, specifically '''[[vulnerable plaque]]''' (non-occlusive or soft plaque), are widely used in research and clinical practice today.{{cn|date=February 2021}}
[[Carotid]] [[Intima-media thickness]] Scan (CIMT can be measured by B-mode [[ultrasonography]]) measurement has been recommended by the [[American Heart Association]] as the most useful method to identify atherosclerosis and may now very well be the gold standard for detection.<ref>{{
[[Intravascular ultrasound]] is the current most sensitive method detecting and measuring more advanced atheroma within living individuals, but has had limited applications due to cost and body invasiveness.<ref>{{cite journal|title=American College of Cardiology Clinical Expert Consensus Document on Standards for Acquisition, Measurement and Reporting of Intravascular Ultrasound Studies (IVUS)|last1=Mintz|first1=Gary S.|last2=Nissen|first2=Steven E.|journal=[[Journal of the American College of Cardiology]]|date=April 2001|volume=37|issue=5|page=1485|doi=10.1016/S0735-1097(01)01175-5|pmid=11300468|doi-access=free|issn=0735-1097}}</ref><ref>{{cite journal|title=The Dilemma of Diagnosing Coronary Calcification: Angiography Versus Intravascular Ultrasound|last1=Tuzcu|first1=E. Murat|last2=Berkalp|first2=Berktan|last3=de Franco|first3=Anthony C.|last4=Ellis|first4=Stephen G.|last5=Goormastic|first5=Marlene|last6=Whitlow|first6=Patrick L.|last7=Franco|first7=Irving|last8=Raymond|first8=Russell E.|last9=Nissen|first9=Steven E.|journal=[[Journal of the American College of Cardiology]]|date=March 1996|volume=27|issue=4|pages=832–838|doi=10.1016/0735-1097(95)00537-4|pmid=8613611|doi-access=free|issn=0735-1097}}</ref>
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