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{{Short description|Automatic, involuntary response to a stimulus}}
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{{Other uses|Reflex (disambiguation)}}
{{Redirect|Reflectory|the album|Reflectory (album){{!}}''Reflectory'' (album)}}
{{human centric|date=September 2022}}
 
In [[biology]], a '''reflex''', or '''reflex action''', is an involuntary, unplanned sequence or action<ref>{{cite web |urlauthor=https://www.crackyourtarget.com/reflex-action.htmlparveen |date=November 11, 2020 |title=Reflex action |work={{!}} Definition, Types and Mechanism and Important solved questions |publisherurl=Crack Your Target |date=November 11, 2020 |author=parveenhttps://www.crackyourtarget.com/reflex-action.html |access-date=3 April 2021 |publisher=Crack Your Target}}</ref> and nearly instantaneous response to a [[Stimulus (physiology)|stimulus]].<ref>Purves (2004). ''Neuroscience: Third Edition''. Massachusetts, Sinauer Associates, Inc. {{ISBN|0-87893-725-0}}</ref><ref name="M-W">{{cite web |title=Definition of REFLEXreflex |url=https://www.merriam-webster.com/dictionary/reflex |website=www.merriamDictionary by Merriam-webster.comWebster |date=25 December 2023 |language=en}}</ref>
[[File:Improved General Reflex Diagram.png|thumb|429x429px|The simplest reflex is initiated by a stimulus, which activates an afferent nerve. The signal is then passed to a response neuron, which generates a response.]]
Reflexes are found with varying levels of complexity in organisms with a [[nervous system]]. A reflex occurs via [[Neuralneural pathway|neural pathways]]s in the nervous system called [[Reflexreflex arc|reflex arcs]]s. A stimulus initiates a neural signal, which is carried to a [[synapse]]. The signal is then transferred across the synapse to a [[motor neuron]], which evokes a target response. These neural signals do not always travel to the brain,<ref name=":02">{{Cite journal |date=2006-02-01 |title=Spinal reflexes, mechanisms and concepts: From Eccles to Lundberg and beyond |url=https://www.sciencedirect.com/science/article/pii/S0301008206000335 |journal=Progress in Neurobiology |language=en |volume=78 |issue=3–5 |pages=215–232 |doi=10.1016/j.pneurobio.2006.04.001 |issn=0301-0082|last1=Hultborn |first1=Hans |pmid=16716488 |s2cid=25904937 }}</ref> so many reflexes are an automatic response to a stimulus that does not receive or need conscious thought.<ref name="FD">{{cite web |title=tendon reflex |url=http://medical-dictionary.thefreedictionary.com/tendon+reflex |website=TheFreeDictionary.com[[The Free Dictionary]]}}</ref>
 
Many reflexes are fine-tuned to increase organism survival and self-defense.<ref>{{Cite journal |last=Price |first=Joseph L. |date=2005-12-05 |title=Free will versus survival: Brain systems that underlie intrinsic constraints on behavior |url=https://onlinelibrary.wiley.com/doi/10.1002/cne.20750 |journal=The Journal of Comparative Neurology |language=en |volume=493 |issue=1 |pages=132–139 |doi=10.1002/cne.20750 |pmid=16255003 |s2cid=18455906 |issn=0021-9967|doi-access=free }}</ref> This is observed in reflexes such as the [[Startle response|startle reflex]], which provides an automatic response to an unexpected stimulistimulus, and the feline [[Cat righting reflex|feline righting reflex]], which reorients a cat's body when falling to ensure safe landing. The simplest type of reflex, a short-latency reflex, has a single synapse, or junction, in the signaling pathway.<ref>{{Cite book |last=Pierrot-Deseilligny |first=Emmanuel |title=The Circuitry of the Human Spinal Cord: Its Role in Motor Control and Movement Disorders |publisher=Cambridge University Press |year=2005 |isbn=9780511545047978-0-511-54504-7}}</ref> Long-latency reflexes produce nerve signals that are transduced across multiple synapses before generating the reflex response.
 
==Types of human reflexes==
===MyotaticAutonomic vs skeletal reflexes===
''Reflex'' is an anatomical concept and it refers to a
loop consisting, in its simplest form, of a sensory
nerve, the input, and a motor nerve, the output.
Autonomic does not mean automatic. The term ''autonomic'' is an anatomical term and it refers
to a type of nervous system in animals and humans
that is very primitive. ''Skeletal'' or ''somatic'' are,
similarly, anatomical terms that refer to a type of
nervous system that is more recent in terms of
evolutionary development. There are autonomic
reflexes and skeletal, somatic reflexes.<ref>Nikoletseas Michael M. (2010) Behavioral and Neural Plasticity. {{ISBN|978-1-4537-8945-2}}</ref>
 
===Myotatic reflexes===
The myotatic or muscle [[stretch reflex]]es (sometimes known as ''deep tendon reflexes'') provide information on the integrity of the [[central nervous system]] and [[peripheral nervous system]]. This information can be detected using [[Electromyography|electromyography (EMG)]].<ref name=":1">{{Cite journal |last1=Tsuji |first1=Hironori |last2=Misawa |first2=Haruo |last3=Takigawa |first3=Tomoyuki |last4=Tetsunaga |first4=Tomoko |last5=Yamane |first5=Kentaro |last6=Oda |first6=Yoshiaki |last7=Ozaki |first7=Toshifumi |date=2021-01-27 |title=Quantification of patellar tendon reflex using portable mechanomyography and electromyography devices |journal=Scientific Reports |language=en |volume=11 |issue=1 |pages=2284 |doi=10.1038/s41598-021-81874-5 |issn=2045-2322 |pmc=7840930 |pmid=33504836}}</ref> Generally, decreased reflexes indicate a peripheral problem, and lively or exaggerated reflexes a central one.<ref name=":1" /> A stretch reflex is the contraction of a muscle in response to its lengthwise stretch.
 
The myotatic or muscle [[stretch reflex]]es (sometimes known as ''deep tendon reflexes'') provide information on the integrity of the [[central nervous system]] and [[peripheral nervous system]]. This information can be detected using [[Electromyography|electromyography (EMG)]].<ref name=":1">{{Cite journal |last1=Tsuji |first1=Hironori |last2=Misawa |first2=Haruo |last3=Takigawa |first3=Tomoyuki |last4=Tetsunaga |first4=Tomoko |last5=Yamane |first5=Kentaro |last6=Oda |first6=Yoshiaki |last7=Ozaki |first7=Toshifumi |date=2021-01-27 |title=Quantification of patellar tendon reflex using portable mechanomyography and electromyography devices |journal=Scientific Reports |language=en |volume=11 |issue=1 |pages=2284 |doi=10.1038/s41598-021-81874-5 |issn=2045-2322 |pmc=7840930 |pmid=33504836 |doi-access=free|bibcode=2021NatSR..11.2284T }}</ref> Generally, decreased reflexes indicate a peripheral problem, and lively or exaggerated reflexes a central one.<ref name=":1" /> A stretch reflex is the contraction of a muscle in response to its lengthwise stretch.
* [[Biceps reflex]] ([[cervical spinal nerve 5|C5]], [[cervical spinal nerve 6|C6]])
* [[Brachioradialis reflex]] (C5, C6, [[cervical spinal nerve 7|C7]])
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===Tendon reflex===
A [[tendon reflex]] is the contraction of a muscle in response to striking its [[tendon]]. The [[Golgi tendon reflex]] is the inverse of a stretch reflex.
 
===Reflexes involving cranial nerves===
 
{| class="wikitable"
| '''Name''' || '''Sensory''' || '''Motor'''
|-
| [[Pupillary light reflex]] || II [[Optic nerve|II]]|| [[Oculomotor nerve|III]]
|-
| [[Accommodation reflex]] || II || III
|-
| [[Jaw jerk reflex]] || V || V
|-
| [[CornealJaw jerk reflex]], also known as the|| [[blinkTrigeminal nerve|V]] reflex || V || VII
|-
| [[Corneal reflex]], also known as the [[blink]] reflex || V || [[Facial nerve|VII]]
|-
| [[Glabellar reflex]] || V || VII
|-
| [[Vestibulo-ocular reflex]] || VIII[[Vestibulocochlear nerve|VIII]]|| III, [[Trochlear nerve|IV]], [[Abducens nerve|VI]] +
|-
| [[Gag reflex]] || IX[[Glossopharyngeal nerve|IX]]|| X[[Vagus nerve|X]]
|}
 
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[[Image:Greifreflex.JPG|thumb|Grasp reflex]]<!-- Deleted image removed: [[Image:Flexor Reflex.jpg|thumb|spinal cord]] -->
[[Newborn babies]] have a number of other reflexes which are not seen in adults, referred to as '''primitive reflexes'''. These automatic reactions to stimuli enable infants to respond to the environment before any learning has taken place. They include:
* [[Asymmetrical tonic neck reflex]] (ATNR)
 
* [[Asymmetrical tonic neck reflex]] (ATNR)
* [[Palmomental reflex]]
* [[Moro reflex]], also known as the startle reflex
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* [[Primitive reflexes#Rooting reflex|Rooting reflex]]
* [[Primitive reflexes#Sucking reflex|Sucking reflex]]
* [[Symmetrical tonic neck reflex]] (STNR)
* [[Tonic labyrinthine reflex]] (TLR)
 
===Other kinds of reflexes===
Other reflexes found in the central nervous system include:
* [[Abdominal reflex]]es (T6-L1)
* [[Gastrocolic reflex]]
* [[Anal wink|Anocutaneous reflex]] (S2-S4)
* [[Baroreflex]]
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* [[Startle reflex]]
* [[Withdrawal reflex]]
** [[Crossed extensor reflex]]
Many of these reflexes are quite complex, requiring a number of synapses in a number of different nuclei in the [[Centralcentral nervous system|CNS]] (e.g., the [[escape reflex]]). Others of these involve just a couple of synapses to function (e.g., the [[withdrawal reflex]]).
Processes such as [[breathbreathing]]ing, [[digestion]], and the maintenance of the [[Heart rate|heartbeat]] can also be regarded as reflex actions, according to some definitions of the term.
 
===Grading===
{{Unreferenced section|date=April 2023}}
In [[medicine]], reflexes are often used to assess the health of the [[nervous system]]. [[physician|Doctors]] will typically grade the activity of a reflex on a scale from 0 to 4. While 2+ is considered normal, some healthy individuals are hypo-reflexive and register all reflexes at 1+, while others are hyper-reflexive and register all reflexes at 3+.
 
{|class="wikitable"
|'''Grade '''|| '''Description'''
|-
| 0 || Absent ("mute")
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| 3+ or +++ || Hyperactive ''without'' [[clonus]], with spread to adjacent muscle groups
|-
| 4+ or ++++ || Hyperactive '''with''' [[clonus]]
|}
Depending on where you are, another way of grading is from –4 (absent) to +4 (clonus), where 0 is "normal".
 
== Reflex modulation ==
[[File:Demonstration of reflex reversal.svg|thumb|An example of reflex reversal is depicted. Activating the same spinal reflex pathway can cause limb flexion while standing, and extension while walking.]]
Naively, weSome might imagine that reflexes are immutable. In reality, however, most reflexes are flexible and can be substantially modified to match the requirements of the behavior in both vertebrates and invertebrates.<ref>{{cite journal |vauthors=Pearson KG |date=1993 |title=Common principles of motor control in vertebrates and invertebrates |url=https://www.annualreviews.org/doi/10.1146/annurev.ne.16.030193.001405 |journal=[[Annual Review of Neuroscience]] |volume=16 |pages=265–97 |doi=10.1146/annurev.ne.16.030193.001405 |pmid=8460894}}</ref><ref>{{cite journal |vauthors=Büschges A, Manira AE |date=December 1998 |title=Sensory pathways and their modulation in the control of locomotion |url=https://www.sciencedirect.com/science/article/abs/pii/S0959438898801153 |journal=[[Current Opinion in Neurobiology]] |volume=8 |issue=6 |pages=733–9 |doi=10.1016/S0959-4388(98)80115-3 |pmid=9914236 |s2cid=18521928}}</ref><ref>{{cite journal |vauthors=Tuthill JC, Azim E |date=March 2018 |title=Proprioception |url=https://www.cell.com/current-biology/fulltext/S0960-9822(18)30097-6 |journal=[[Current Biology]] |language=English |volume=28 |issue=5 |pages=R194–R203 |doi=10.1016/j.cub.2018.01.064 |pmid=29510103 |s2cid=235330764 |doi-access=free|bibcode=2018CBio...28.R194T }}</ref>
 
A good example of reflex modulation is the [[stretch reflex]].<ref>{{Cite journal |vauthors=Bässler U |date=March 1976 |title=Reversal of a reflex to a single motoneuron in the stick insect Çarausius morosus |url=https://link.springer.com/article/10.1007/BF00365594 |journal=[[Biological Cybernetics]] |language=en |volume=24 |issue=1 |pages=47–49 |doi=10.1007/BF00365594 |issn=1432-0770 |s2cid=12007820}}</ref><ref>{{cite journal |vauthors=Forssberg H, Grillner S, Rossignol S |date=August 1977 |title=Phasic gain control of reflexes from the dorsum of the paw during spinal locomotion |url=https://www.sciencedirect.com/science/article/abs/pii/0006899377907107 |journal=[[Brain Research]] |volume=132 |issue=1 |pages=121–39 |doi=10.1016/0006-8993(77)90710-7 |pmid=890471 |s2cid=32578292}}</ref><ref>{{cite journal | vauthors = Capaday C, Stein RB |date=May title1986 |title= Amplitude modulation of the soleus H-reflex in the human during walking and standing | journal = The Journal of Neuroscience | volume = 6 | issue = 5 | pages = 1308–13 | date = May 1986 | doi = 10.1523/JNEUROSCI.06-05-01308.1986 |pmc=6568550 |pmid = 3711981 | pmc doi-access= 6568550 free}}</ref><ref name=":0">{{cite journal | vauthors = Clarac F, Cattaert D, Le Ray D |date=May title2000 |title= Central control components of a 'simple' stretch reflex |url=https://hal.archives-ouvertes.fr/hal-02346762/file/2000%20Clarac%20et%20al%20-%20TrendsNeurosci.pdf |journal = Trends in Neurosciences | volume = 23 | issue = 5 | pages = 199–208 | date = May 2000 | pmid = 10782125 | doi = 10.1016/s0166-2236(99)01535-0 |pmid=10782125 |s2cid = 10113723 | url doi-access= https://hal.archives-ouvertes.fr/hal-02346762/file/2000%20Clarac%20et%20al%20-%20TrendsNeurosci.pdf free}}</ref> When a muscle is stretched at rest, the stretch reflex leads to contraction of the muscle, thereby opposing stretch (resistance reflex). This helps to stabilize posture. During voluntary movements, however, the intensity (gain) of the reflex is reduced or its sign is even reversed. This prevents resistance reflexes from impeding movements.
 
The underlying sites and mechanisms of reflex modulation are not fully understood. There is evidence that the output of sensory neurons is directly modulated during behavior—for example, through [[presynaptic inhibition]].<ref>{{cite journal | vauthors = Wolf H, Burrows M |date=August title1995 |title= Proprioceptive sensory neurons of a locust leg receive rhythmic presynpatic inhibition during walking | journal = The Journal of Neuroscience | volume = 15 | issue = 8 | pages = 5623–36 | date = August 1995 | doi = 10.1523/JNEUROSCI.15-08-05623.1995 |pmc=6577635 |pmid = 7643206 | pmc doi-access= 6577635 free}}</ref><ref>{{cite journal | vauthors = Sauer AE, Büschges A, Stein W | title = Role of presynaptic inputs to proprioceptive afferents in tuning sensorimotor pathways of an insect joint control network | journal = Journal of Neurobiology | volume = 32 | issue = 4 | pages = 359–76 | date = April 1997 | pmid = 9087889 | doi = 10.1002/(SICI)1097-4695(199704)32:4<359::AID-NEU1>3.0.CO;2-5 | doi-access = free }}</ref> The effect of sensory input upon motor neurons is also influenced by interneurons in the [[spinal cord]] or [[ventral nerve cord]]<ref name=":0" /> and by descending signals from the brain.<ref>{{cite journal |vauthors=Mu L, Ritzmann RE |date=December 20, 2007 |title=Interaction between descending input and thoracic reflexes for joint coordination in cockroach: I. descending influence on thoracic sensory reflexes |url=https://link.springer.com/article/10.1007/s00359-007-0307-x |journal=[[Journal of Comparative Physiology A]] |volume=194 |issue=3 |pages=283–98 |doi=10.1007/s00359-007-0307-x |pmid=18094976 |s2cid=25167774}}</ref><ref>{{cite journal | vauthors = Martin JP, Guo P, Mu L, Harley CM, Ritzmann RE | title = Central-complex control of movement in the freely walking cockroach | journal = Current Biology | volume = 25 | issue = 21 | pages = 2795–2803 | date = November 2015 | pmid = 26592340 | doi = 10.1016/j.cub.2015.09.044 | doi-access = free | bibcode = 2015CBio...25.2795M }}</ref><ref>{{cite journal | vauthors = Hsu LJ, Zelenin PV, Orlovsky GN, Deliagina TG |date=February title2017 |title= Supraspinal control of spinal reflex responses to body bending during different behaviours in lampreys | journal = The Journal of Physiology | volume = 595 | issue = 3 | pages = 883–900 |doi=10.1113/JP272714 date |pmc= February 20175285725 | pmid = 27589479 | pmc = 5285725 | doi -access= 10.1113/JP272714 free}}</ref>
 
==Other reflexes==
Breathing can also be considered both involuntary and voluntary, since breath can be held through [[internal intercostal muscles]].<ref>{{Cite journal |last1=Mitchell |first1=R. A. |last2=Berger |first2=A. J. |date=February 1975 |title=Neural regulation of respiration |url=https://pubmed.ncbi.nlm.nih.gov/1089375/ |journal=[[The American Review of Respiratory Disease]] |publisher=[[American Thoracic Society]] |volume=111 |issue=2 |pages=206–224 |doi=10.1164/arrd.1975.111.2.206 |doi-broken-date=31 DecemberJanuary 20222024 |issn=0003-0805 |pmid=1089375}}</ref><ref>{{Cite journal |last1=Park |first1=Hyeong-Dong |last2=Barnoud |first2=Coline |last3=Trang |first3=Henri |last4=Kannape |first4=Oliver A. |last5=Schaller |first5=Karl |last6=Blanke |first6=Olaf |date=February 6, 2020 |title=Breathing is coupled with voluntary action and the cortical readiness potential |journal=[[Nature Communications]] |publisher=[[Nature Portfolio]] |volume=11 |issue=1 |pages=289 |bibcode=2020NatCo..11..289P |doi=10.1038/s41467-019-13967-9 |issn=2041-1723 |pmc=7005287 |pmid=32029711 |bibcodedoi-access=2020NatCo..11..289P free}}</ref><ref>{{Cite webnews |date=2018-07-22 |title=21.10B: Neural Mechanisms (Cortex) |url=https://med.libretexts.org/Bookshelves/Anatomy_and_Physiology/Book%3A_Anatomy_and_Physiology_(Boundless)/21%3A_Respiratory_System/21.10%3A_Respiration_Control/21.10B%3A_Neural_Mechanisms_(Cortex) |access-date=2022-09-10 |website=[[LibreTexts|Medicine LibreTexts]] |language=en}}</ref>
 
== See also ==
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* [[Instinct]]
* [[Jumping Frenchmen of Maine]]
* [[List of reflexes (alphabetical)]]
* [[Preflexes]]
* [[Voluntary action]]