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Line 24: \| deaths = }} An '''atheroma''', or '''atheromatous plaque''' ~~("plaque")~~, is an abnormal and reversible accumulation of material in the [[tunica intima\|inner layer]] of an [[artery]] wall.<ref>{{cite journal \|last1=Lusis \|first1=Aldons J. \|title=Atherosclerosis \|journal=Nature \|date=September 2000 \|volume=407 \|issue=6801 \|pages=233–241 \|doi=10.1038/35025203 \|pmid=11001066 \|pmc=2826222 }}</ref><ref>{{Cite journal\|last1=Francis\|first1=Andrew A\|last2=Pierce\|first2=Grant N\|date=2011\|title=An integrated approach for the mechanisms responsible for atherosclerotic plaque regression\|journal=Experimental & Clinical Cardiology\|volume=16\|issue=3\|pages=77–86\|issn=1205-6626\|pmc=3209544\|pmid=22065938}}</ref> The material consists of mostly [[macrophage\|macrophage cells]],<ref name="pmid20376052">{{cite journal \|last1=Hotamisligil \|first1=Gökhan S \|title=Endoplasmic reticulum stress and atherosclerosis \|journal=Nature Medicine \|date=April 2010 \|volume=16 \|issue=4 \|pages=396–399 \|doi=10.1038/nm0410-396 \|pmid=20376052 \|pmc=2897068 }}</ref><ref name="pmid22356914">{{cite journal \|last1=Oh \|first1=Jisu \|last2=Riek \|first2=Amy E. \|last3=Weng \|first3=Sherry \|last4=Petty \|first4=Marvin \|last5=Kim \|first5=David \|last6=Colonna \|first6=Marco \|last7=Cella \|first7=Marina \|last8=Bernal-Mizrachi \|first8=Carlos \|title=Endoplasmic Reticulum Stress Controls M2 Macrophage Differentiation and Foam Cell Formation \|journal=Journal of Biological Chemistry \|date=6 April 2012 \|volume=287 \|issue=15 \|pages=11629–11641 \|doi=10.1074/jbc.M111.338673 \|pmid=22356914 \|pmc=3320912 \|doi-access=free }}</ref> or debris, containing [[lipids]], calcium and a variable amount of fibrous [[connective tissue]]. The accumulated material forms a swelling in the artery wall, which may intrude into the [[Lumen (anatomy)\|lumen]] of the artery, [[stenosis\|narrowing]] it and restricting blood flow. Atheroma is the [[pathological]] basis for the disease entity [[atherosclerosis]], a subtype of [[arteriosclerosis]].{{fact\|date=September 2020}}

Atheroma: Difference between revisions