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* neurodevelopmental disorders and chromosomal abnormalities, including [[velocardiofacial syndrome]]
* neurodegenerative disorders, such as [[Alzheimer's disease]], [[dementia with Lewy bodies]], and [[Parkinson's disease]], [[metachromatic leukodystrophy]], [[Huntington disease]]<ref>{{cite journal | vauthors = Karameh WK, Murari G, Schweizer TA, Munoz DG, Fischer CE | title = Psychosis in neurodegenerative disorders: recent developments | language = en-US | journal = Current Opinion in Psychiatry | volume = 32 | issue = 2 | pages = 117–122 | date = March 2019 | pmid = 30520740 | doi = 10.1097/YCO.0000000000000476 | s2cid = 54560300 }}</ref>
* focal neurological disease, such as [[stroke]], [[brain tumor]]s,<ref name="Brain_tumor">{{cite journal | vauthors = Lisanby SH, Kohler C, Swanson CL, Gur RE | title = Psychosis Secondary to Brain Tumor | journal = Seminars in Clinical Neuropsychiatry | volume = 3 | issue = 1 | pages = 12–22 | date = January 1998 | pmid = 10085187 }}</ref> [[multiple sclerosis]], [[brain calcification<ref name="Continuum" /> and some forms of [[epilepsy]]
* malignancy (typically via masses in the brain, [[paraneoplastic syndrome]]s)<ref name="Continuum" />
* infectious and postinfectious syndromes, including infections causing [[delirium]], [[viral encephalitis]], [[HIV/AIDS]],<ref name="Munjal 681–712">{{cite journal | vauthors = Munjal S, Ferrando SJ, Freyberg Z | title = Neuropsychiatric Aspects of Infectious Diseases: An Update | journal = Critical Care Clinics | volume = 33 | issue = 3 | pages = 681–712 | date = July 2017 | pmid = 28601141 | pmc = 5771230 | doi = 10.1016/j.ccc.2017.03.007 }}</ref> [[malaria]],<ref>{{cite journal | vauthors = Nevin RL, Croft AM | title = Psychiatric effects of malaria and anti-malarial drugs: historical and modern perspectives | journal = Malaria Journal | volume = 15 | pages = 332 | date = June 2016 | pmid = 27335053 | pmc = 4918116 | doi = 10.1186/s12936-016-1391-6 | doi-access = free }}</ref> [[syphilis]]<ref name="Munjal 681–712" />
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