'''Laudanosine''' or '''''N''-methyltetrahydropapaverine''' is a recognized metabolite of [[atracurium]] and [[cisatracurium]]<ref name=Fodale>{{cite journal |author=Fodale V, Santamaria LB |title=Laudanosine, an atracurium and cisatracurium metabolite |journal=Eur J Anaesthesiol |volume=19 |issue=7 |pages=466–73 |year=2002 |month=July |pmid=12113608}}</ref> thatof decreases[[atracurium]] the seizure threshold, thus it can cause seizures at sufficient concentrations. It also occurs naturally in minute amounts (0.1%) inand [[opiumcisatracurium]],. fromLaudanosine whichdecreases itthe wasseizure first isolated in 1871.<ref>{{cite book |chapterurl=http://books.google.com/books?id=KxTKLlac60wC&pg=PA55&dq=laudanosine&sig=ACfU3U2OZxmvO0Pl8Jnp8KuGXHzMllcnQA#PPA48threshold,M1|chapter=Theand Benzylisoquinolinethus Alkaloidsit |author=Burgercan Ainduce |title=Theseizures Alkaloids:if Chemistrypresent andat Physiologysufficient |origyear=1954threshold |year=2005concentrations; |volume=4however |editor=Manskesuch RHF,concentrations Holmesare HLunlikely (eds.)to |pages=p.be 48produced |location=Newconsequent Yorkto |publisher=Academicchemodegradable Pressmetabolism |isbn=0124695043}}of Retrievedclinically Septemberadministered 18,doses 2008 throughof [[Google Book Searchcisatracurium]].</ref>Partialor [[Dehydration reaction|dehydrationatracurium]]. of laudanosine will lead to [[papaverine]].
Laudanosine also occurs naturally in minute amounts (0.1%) in [[opium]], from which it was first isolated in 1871.<ref>{{cite book |chapterurl=http://books.google.com/books?id=KxTKLlac60wC&pg=PA55&dq=laudanosine&sig=ACfU3U2OZxmvO0Pl8Jnp8KuGXHzMllcnQA#PPA48,M1 |chapter=The Benzylisoquinoline Alkaloids |author=Burger A |title=The Alkaloids: Chemistry and Physiology |origyear=1954 |year=2005 |volume=4 |editor=Manske RHF, Holmes HL (eds.) |pages=p. 48 |location=New York |publisher=Academic Press |isbn=0124695043}} Retrieved September 18, 2008 through [[Google Book Search]].</ref> Partial [[Dehydration reaction|dehydration]] of laudanosine will lead to [[papaverine]].
Laudanosine is a [[benzylisoquinoline]] [[alkaloid]]. It has been shown to interact with [[GABA receptor]]s, [[opioid receptor]]s, and [[nicotinic acetylcholine receptor]]s.<ref name=Fodale/>▼
▲Laudanosine is a [[benzylisoquinolinebenzyltetrahydroisoquinoline]] [[alkaloid]]. It has been shown to interact with [[GABA receptor]]s, [[opioid receptor]]s, and [[nicotinic acetylcholine receptor]]s.<ref name=Fodale/>
