Fc fragment of IgA receptor (FCAR) is a human gene[3] that codes for the transmembrane receptor Fc
Though Fc
Structure
editThe Fc
Two FCAR alleles differing by a single nucleotide polymorphism (SNP) code for two Fc
Alternative splicing of the transcript from this gene produces ten mRNA variants encoding different isoforms.[3]
Inside-Out Signaling
editFc
Once primed, Fc
Function
editSignaling and the resulting cellular response caused by Fc
Despite signaling via ITAMs, which typically initiate activation cascades, Fc
The anti-inflammatory role of monomeric IgA-Fc
The secreted form of IgA (sIgA), a homodimer secreted across epithelial linings such as the gut epithelium, is sterically hindered in its binding to Fc
Fc
Interactions
editSee also
editReferences
edit- ^ a b c ENSG00000284004, ENSG00000273738, ENSG00000283953, ENSG00000276985, ENSG00000275970, ENSG00000284061, ENSG00000283750, ENSG00000278415, ENSG00000186431, ENSG00000275136, ENSG00000276858, ENSG00000284245, ENSG00000275269, ENSG00000274580 GRCh38: Ensembl release 89: ENSG00000275564, ENSG00000284004, ENSG00000273738, ENSG00000283953, ENSG00000276985, ENSG00000275970, ENSG00000284061, ENSG00000283750, ENSG00000278415, ENSG00000186431, ENSG00000275136, ENSG00000276858, ENSG00000284245, ENSG00000275269, ENSG00000274580 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: FCAR Fc fragment of IgA, receptor for".
- ^ a b c d e f g h i j k l Bakema JE, van Egmond M (November 2011). "The human immunoglobulin A Fc receptor Fc
α RI: a multifaceted regulator of mucosal immunity". Mucosal Immunology. 4 (6): 612–24. doi:10.1038/mi.2011.36. PMID 21937986. - ^ a b c d e f g h i j k Aleyd E, Heineke MH, van Egmond M (November 2015). "The era of the immunoglobulin A Fc receptor Fc
α RI; its function and potential as target in disease". Immunological Reviews. 268 (1): 123–38. doi:10.1111/imr.12337. PMID 26497517. S2CID 21300390. - ^ Smith PD, Smythies LE, Mosteller-Barnum M, Sibley DA, Russell MW, Merger M, Sellers MT, Orenstein JM, Shimada T, Graham MF, Kubagawa H (September 2001). "Intestinal macrophages lack CD14 and CD89 and consequently are down-regulated for LPS- and IgA-mediated activities". Journal of Immunology. 167 (5): 2651–6. doi:10.4049/jimmunol.167.5.2651. PMID 11509607.
- ^ a b c Wu J, Ji C, Xie F, Langefeld CD, Qian K, Gibson AW, Edberg JC, Kimberly RP (March 2007). "FcalphaRI (CD89) alleles determine the proinflammatory potential of serum IgA". Journal of Immunology. 178 (6): 3973–82. doi:10.4049/jimmunol.178.6.3973. PMID 17339498.
- ^ a b c Brandsma AM, Jacobino SR, Meyer S, ten Broeke T, Leusen JH (November 2015). "Fc receptor inside-out signaling and possible impact on antibody therapy". Immunological Reviews. 268 (1): 74–87. doi:10.1111/imr.12332. PMID 26497514. S2CID 20610179.
- ^ a b c d e Mkaddem SB, Rossato E, Heming N, Monteiro RC (April 2013). "Anti-inflammatory role of the IgA Fc receptor (CD89): from autoimmunity to therapeutic perspectives". Autoimmunity Reviews. 12 (6): 666–9. doi:10.1016/j.autrev.2012.10.011. PMID 23201915.
- ^ Getahun A, Cambier JC (November 2015). "Of ITIMs, ITAMs, and ITAMis: revisiting immunoglobulin Fc receptor signaling". Immunological Reviews. 268 (1): 66–73. doi:10.1111/imr.12336. PMC 4621791. PMID 26497513.
- ^ a b Pasquier B, Launay P, Kanamaru Y, Moura IC, Pfirsch S, Ruffié C, Hénin D, Benhamou M, Pretolani M, Blank U, Monteiro RC (January 2005). "Identification of FcalphaRI as an inhibitory receptor that controls inflammation: dual role of FcRgamma ITAM". Immunity. 22 (1): 31–42. doi:10.1016/j.immuni.2004.11.017. PMID 15664157.
- ^ van Egmond M, Bakema JE (June 2013). "Neutrophils as effector cells for antibody-based immunotherapy of cancer". Seminars in Cancer Biology. 23 (3): 190–9. doi:10.1016/j.semcancer.2012.12.002. PMID 23287459.
- ^ Morton HC, van den Herik-Oudijk IE, Vossebeld P, Snijders A, Verhoeven AJ, Capel PJ, van de Winkel JG (December 1995). "Functional association between the human myeloid immunoglobulin A Fc receptor (CD89) and FcR gamma chain. Molecular basis for CD89/FcR gamma chain association". The Journal of Biological Chemistry. 270 (50): 29781–7. doi:10.1074/jbc.270.50.29781. PMID 8530370.
Further reading
edit- Morton HC, van Egmond M, van de Winkel JG (1996). "Structure and function of human IgA Fc receptors (Fc alpha R)". Critical Reviews in Immunology. 16 (4): 423–40. PMID 8954257.
- Morton HC, Brandtzaeg P (2001). "CD89: the human myeloid IgA Fc receptor". Archivum Immunologiae et Therapiae Experimentalis. 49 (3): 217–29. PMID 11478396.
- Martin AM, Kulski JK, Witt C, Pontarotti P, Christiansen FT (February 2002). "Leukocyte Ig-like receptor complex (LRC) in mice and men". Trends in Immunology. 23 (2): 81–8. doi:10.1016/S1471-4906(01)02155-X. PMID 11929131.
- Monteiro RC, Van De Winkel JG (2003). "IgA Fc receptors". Annual Review of Immunology. 21: 177–204. doi:10.1146/annurev.immunol.21.120601.141011. PMID 12524384.
- Kremer EJ, Kalatzis V, Baker E, Callen DF, Sutherland GR, Maliszewski CR (April 1992). "The gene for the human IgA Fc receptor maps to 19q13.4". Human Genetics. 89 (1): 107–8. doi:10.1007/BF00207054. PMID 1577457. S2CID 22356303.
- Maliszewski CR, March CJ, Schoenborn MA, Gimpel S, Shen L (December 1990). "Expression cloning of a human Fc receptor for IgA". The Journal of Experimental Medicine. 172 (6): 1665–72. doi:10.1084/jem.172.6.1665. PMC 2188749. PMID 2258698.
- Pfefferkorn LC, Yeaman GR (October 1994). "Association of IgA-Fc receptors (Fc alpha R) with Fc epsilon RI gamma 2 subunits in U937 cells. Aggregation induces the tyrosine phosphorylation of gamma 2". Journal of Immunology. 153 (7): 3228–36. doi:10.4049/jimmunol.153.7.3228. PMID 7522255. S2CID 44693625.
- de Wit TP, Morton HC, Capel PJ, van de Winkel JG (August 1995). "Structure of the gene for the human myeloid IgA Fc receptor (CD89)". Journal of Immunology. 155 (3): 1203–9. doi:10.4049/jimmunol.155.3.1203. PMID 7636188. S2CID 12283570.
- Dürrbaum-Landmann I, Kaltenhäuser E, Flad HD, Ernst M (April 1994). "HIV-1 envelope protein gp120 affects phenotype and function of monocytes in vitro". Journal of Leukocyte Biology. 55 (4): 545–51. doi:10.1002/jlb.55.4.545. PMID 8145026. S2CID 44412688.
- Monteiro RC, Hostoffer RW, Cooper MD, Bonner JR, Gartland GL, Kubagawa H (October 1993). "Definition of immunoglobulin A receptors on eosinophils and their enhanced expression in allergic individuals". The Journal of Clinical Investigation. 92 (4): 1681–5. doi:10.1172/JCI116754. PMC 288327. PMID 8408621.
- Morton HC, Schiel AE, Janssen SW, van de Winkel JG (1996). "Alternatively spliced forms of the human myeloid Fc alpha receptor (CD89) in neutrophils". Immunogenetics. 43 (4): 246–7. doi:10.1007/BF00587311. PMID 8575829.
- Patry C, Sibille Y, Lehuen A, Monteiro RC (June 1996). "Identification of Fc alpha receptor (CD89) isoforms generated by alternative splicing that are differentially expressed between blood monocytes and alveolar macrophages". Journal of Immunology. 156 (11): 4442–8. doi:10.4049/jimmunol.156.11.4442. PMID 8666819. S2CID 45370016.
- Carayannopoulos L, Hexham JM, Capra JD (April 1996). "Localization of the binding site for the monocyte immunoglobulin (Ig) A-Fc receptor (CD89) to the domain boundary between Calpha2 and Calpha3 in human IgA1". The Journal of Experimental Medicine. 183 (4): 1579–86. doi:10.1084/jem.183.4.1579. PMC 2192530. PMID 8666916.
- Pleass RJ, Andrews PD, Kerr MA, Woof JM (September 1996). "Alternative splicing of the human IgA Fc receptor CD89 in neutrophils and eosinophils". The Biochemical Journal. 318 ( Pt 3) (3): 771–7. doi:10.1042/bj3180771. PMC 1217685. PMID 8836118.
- Reterink TJ, Verweij CL, van Es LA, Daha MR (October 1996). "Alternative splicing of IgA Fc receptor (CD89) transcripts". Gene. 175 (1–2): 279–80. doi:10.1016/0378-1119(96)00152-7. PMID 8917112.
- van Dijk TB, Bracke M, Caldenhoven E, Raaijmakers JA, Lammers JW, Koenderman L, de Groot RP (December 1996). "Cloning and characterization of Fc alpha Rb, a novel Fc alpha receptor (CD89) isoform expressed in eosinophils and neutrophils". Blood. 88 (11): 4229–38. doi:10.1182/blood.V88.11.4229.4229. PMID 8943858.
- Toyabe S, Kuwano Y, Takeda K, Uchiyama M, Abo T (November 1997). "IgA nephropathy-specific expression of the IgA Fc receptors (CD89) on blood phagocytic cells". Clinical and Experimental Immunology. 110 (2): 226–32. doi:10.1111/j.1365-2249.1997.tb08321.x. PMC 2265504. PMID 9367406.
- Gulle H, Samstag A, Eibl MM, Wolf HM (January 1998). "Physical and functional association of Fc alpha R with protein tyrosine kinase Lyn". Blood. 91 (2): 383–91. doi:10.1182/blood.V91.2.383. PMID 9427690.
External links
edit- CD89+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.